Interdisciplinary Neuroscience Program (MU): Recent submissions
Now showing items 1-20 of 31
-
Impact of the NAD+ salvage pathway on the motor system and bioenergetics
(University of Missouri--Columbia, 2023)Nicotinamide adenine dinucleotide (NAD+) is a metabolite pivotal to numerous cellular functions, including energy metabolism, DNA repair, and protein modification. The majority of NAD+ is generated by the NAD+ salvage ... -
Neurochemical, epigenetic, and structural brain changes associated with prenatal stress exposure, and the mitigating effects of DHA
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] The Developmental Origins of Health and Disease (DOHaD) hypothesis posits that in utero stress exposure can modify developmental trajectories, influencing adult health. Research indicates that ... -
Investigating the long-term effects of non-inertial low-intensity blast-induced mild traumatic brain injury in mice
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] In military contexts, mild traumatic brain injury (mTBI) is reported more than moderate or severe TBI and is frequently caused by low-intensity blast (LIB) exposure. Affected service members and ... -
Real-time detection of dopamine -- aptamer interactions in a nanopore: a label-free toolkit for study of nucleic-acid-based molecular sensors.
(University of Missouri--Columbia, 2021)Understanding how small molecules regulate nucleic acid structures is important in both biomechanism elucidation and biotechnological applications. Through the conformational variation, native nucleic acid motifs can be ... -
Clinical interventions for HIV-associated neurocognitive disorder (hand) : a systematic review
(University of Missouri--Columbia, 2020)Despite the widespread use of antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) continues to be one of the most common central nervous system (CNS) complications of human immunodeficiency virus (HIV), ... -
Disease characterization and pre-clinical testing in canine models of the neuronal ceroid lipofuscinoses
(University of Missouri--Columbia, 2021)The neuronal ceroid lipofuscinoses (NCLs) are inherited lysosomal storage disorders characterized by intracellular accumulation of autofluorescent storage material and by progressive degeneration of neurons in the brain ... -
Examination of biological factors that mediate the influence of physical activity on palatability driven feeding
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Palatability driven feeding- consuming food for pleasure, and voluntary physical activity are mediated by and influence similar neural mechanisms. ... -
Canine degenerative myelopathy : perspectives from aging, microglia and neurofilaments
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Canine degenerative myelopathy (DM) is a late-onset neurodegenerative disease similar to some forms of amyotrophic lateral sclerosis (ALS). Mutations ... -
Low-intensity blast-induced mild traumatic brain injury : linking blast physics to biological outcomes
(University of Missouri--Columbia, 2019)Blast-induced mild traumatic brain injury (mTBI) is of particular concern among military personnel due to exposure to blast energy during military training and combat. The impact of primary low-intensity blast (LIB) mediated ... -
Stress, cognition and functional connectivity in the healthy human
(University of Missouri--Columbia, 2018)Stress is known to negatively impact physiological and psychological processes in humans. While chronic exposure to stress has been implicated in the pathology of numerous physiological and neuropsychological disorders, ... -
Dietary inflammatory index in patients with Alzheimer's dementia compared to controls
(University of Missouri--Columbia, 2018)Alzheimer's dementia (AD) is a chronic neurodegenerative disease causing progressive memory loss, cognitive decline across numerous domains, and, eventually, loss of daily living activities. Mild cognitive impairment (MCI) ... -
Effects of beta-adrenergic antagonism in autism spectrum disorder
(University of Missouri--Columbia, 2016)Effective treatments for individuals with autism spectrum disorder are lacking, especially when it comes to pharmacological intervention, which can be an important addition to behavioral therapy. Currently available agents ... -
Associations between psychophysiological, immune, endocrine, and serotonergic biomarkers of stress and gastrointestinal symptoms in autism spectrum disorder
(University of Missouri--Columbia, 2016)Autism spectrum disorder (ASD) is often accompanied by gastrointestinal (GI) disturbances, which also may impact behavior. Alterations in autonomic, endocrine, and immune system functioning are also frequently observed in ... -
Matrix metalloproteinase-9 : surrogate marker and therapeutic target against neurovascular impairment after cerebral ischemia
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Stroke ranks fourth among all causes of death, and acute ischemic stroke is the most common form. The neurovascular unit (NVU) describes a basic ... -
The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
(University of Missouri--Columbia, 2016)Oxidative and nitrosative stress is known to play an important role in neurodegenerative and neuroinflammatory diseases, such as Alzheimer's disease, Parkinson's disease, ischemic[slash]hemorrhagic stroke, and traumatic ... -
Network coherence in autism spectrum disorder : a multimodal neuroimaging study of functional connectivity and spectroscopy MRI
(University of Missouri--Columbia, 2015)The underlying neuropathology and effects on neuronal activity in individuals with ASD are still being elucidated; as well as their impact on intervention and treatment outcomes. Frontal, temporal, parietal and cerebellar ... -
The role of docosahexaenoic acid in stress reprogramming and behavior
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The role of DHA (Docosahexaenoic acid [22:6(n-3)]) is known to play an important role in complex behaviors such as learning and memory, anxiety and ... -
Interaction between seratonin transporter genotype and prenatal stress on neurodevelopment with implications for autism spectrum disorder
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Prenatal stress has been shown to have a profound and lasting impact on brain development. Stress exposure during pregnancy has been implicated in ... -
The role of the amygdala in palatability and homeostatic models of high-fat feeding
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has demonstrated a dissociation of certain neural mediators that contribute to the increased consumption of a high-fat diet following ... -
CNS effects of blood-borne relaxin on the paraventricular nucleus of the hypothalamus
(University of Missouri--Columbia, 2013)Pregnancy is characterized by increased blood volume and baseline sympathetic nerve activity, and profound cardiovascular adaptations. Relaxin (RLX), an ovarian hormone which is elevated in pregnancy, activates the subfomical ...