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Acid-sensing ion channels as a novel target for drug addiction [abstract]
(2010-03)
Improving the treatment and prevention of drug addiction is an important goal for modern medicine. Ion channels have recently become very attractive targets in the search of new pharmacotherapies. Extracellular proton ...
Creation of 'Super Avastin': A New Nanomedicine Approach for the Treatment of PXE and AMD [abstract]
(2010-02)
Nanomedicine is an emerging medical area that utilizes nanoparticles for the detection and treatment of diseases. The ubiquitous place of gold in Nanomedicine stems from its chemical ability to serve in an unoxidized state ...
An Electro-magnetic cell stimulator [abstract]
(2010-03)
A device to stimulate bone and muscle cell growth and possibly for treatment of bone and muscle injuries is presented. The device, called EStim, generates electric and magnetic pulses at programmable intervals. This device ...
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)
The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ...
Nanostructures for Diagnostics and Delivery [abstract]
(2010)
Nanostructures are increasingly being recognized for their novel applications in biological systems including nanomedicine— the application of nanoscale technologies for diagnosis, treatment and prevention of diseases. ...
Temporal trends in the management of severe hyperglycemia among patients hospitalized with acute myocardial infarction [abstract]
(2010)
Background: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it ...
Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
Authentic embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig, despite over 25 years of effort. Recently, several groups, including ours, have reported derivation of induced ...
Applications of Energetic Materials and Copper Oxide Nanorods for Decontamination [abstract]
(2010-03)
We demonstrate the potential of nanoenergetic coatings and CuO nanorods to decontaminate surfaces infected with bacteria. The methods of decontamination include (i) fast combustion of an energetic paint applied on contaminated ...
Investigation and Optimization of Silorane-Based Polymer System [abstract]
(2010-03)
This research is a collaboration between Department of Oral Biology in the School of Dentistry at UMKC, Department of Chemistry in The College of Arts and Sciences at UMKC, Department of Chemistry at Missouri Science and ...
Translational Approach to Examine the Importance of Aerobic Fitness on Nonalcoholic Fatty Liver Disease [abstract]
(2010)
Low cardiorespiratory fitness, independent of physical activity levels, is the best predictor of early mortality and is linked to type 2 diabetes and CVD. In the absence of exercise training, it is believed that genetic ...
Inhibition Mechanism of EFdA, a Highly Potent Inhibitor of HIV Reverse Transcriptase [abstract]
(2010-02)
The nucleoside 4'-ethynyl-2-fluoro-deoxyadenosine (EFdA) is one of the most
potent antiretroviral nucleosides yet described, inhibiting replication of wild-type and multidrug-resistant HIV-1 strains in vitro (PBMC cells) ...
Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]
(2010-03)
We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 ...
Development and characterization of fluorescent dye-doped nanoparticles with enhanced fluorescence intensity and photostability [abstract]
(2010)
We report the development of fluorescent dye doped organosilicate nanoparticles (DOSNPs) synthesized from poly-methylsilsesquioxane(PMSSQ), resulting in high fluorescence intensity and excellent photostability. The surface ...
Slipped deadlines and sample size shortfalls in clinical trials: a proposed remedy using a Bayesian model with an informative prior distribution [abstract]
(2010-03)
Background: The most common reason why clinical trials fail is that they fall well below their goals for patient accrual. Researchers will frequently overpromise and underdeliver on the number of patients that they can ...
Cancer stem cells in malignant peripheral nerve sheath tumor: Biology and therapeutic ramifications [abstract]
(2010-03)
Although monoclonal in origin, most tumors appear to contain heterogeneous populations of cancer cells. One possible explanation of this tumor heterogeneity is that human tumors are not merely monoclonal expansions of a ...
Engineering Optimal Islets for Transplantation for Type 1 Diabetes [abstract]
(2010-03)
Islet transplantation offers an improvement in the quality of life for those suffering from type 1 diabetes. It is found that islet cells may die during or soon after transplantation. Studies in our lab have shown that ...
Towards the Biological Synthesis of fullerene molecules [abstract]
(2010)
This invention describes the synthesis of carbon fullerene molecules and nanotubes using biological or enzymatic means. Presently carbon nanotubes are synthesized by either chemical vapor deposition or by electrical discharge ...
Comparative oncology and clinical translation of glyco protein conjugated gold nano therapeutic agent (GA-198AuNP) [abstract]
(2010)
As part of our efforts toward clinical translation of GA-198AuNP, our studies are focused on therapeutic efficacy of nanoparticulate GA198AuNP agent in dogs with prostatic carcinoma. The overall goal is to gain clinical ...
UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT) [abstract]
(2010-03)
Diseases of mineralized tissues such as bone and teeth or of the muscles that control bone movement result in significant health costs in terms of suffering, loss of work and productivity, and even death. There is a ...
A Single Antibody based ELISA for the N-terminal sequence of BAG-75, a New Biomarker for Bone Formation [abstract]
(2010)
Bone acidic glycoprotein-75 (BAG-75) is a secreted product of osteoblastic cells localized predominantly to areas of new bone formation. We have identified the N-terminal sequence of BAG-75 as LPVARYQNTEEEE and shown that ...