Browsing 2019 Theses (MU) by Thesis Advisor "Gates, Kent S. (Kent Stephen), 1962-"
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Effects of local sequence on the formation of interstrand DNA cross-links derived from the reaction of an abasic site with a cytosine residue on the opposing strand
(University of Missouri--Columbia, 2019)DNA Interstrand Cross-Links are of special concern due to the difficulty of repair and cytotoxicity of cells associated with these lesions. Interstrand Cross-Links between abasic sites and native nucleobases has shown ... -
Novel DNA Adducts- Chemical Reactions that Model the Generation of interstrand cross-links between a Guanine Residue and a 3'-alkenal end product in duplex DNA
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Modification of DNA by chemicals produced lethal biological effects such as carcinogenesis, cytotoxicity, etc. Abasic site (Ap site) can ...