• Ab Initio Density Functional Theory Optimized Geometries of Vinyl Trialkylammonium, Vinylpyridinium and Vinyldiazonium Tetrafluoroborate Salts with Natural Bond Orbital Charge Distributions in the Gas Phase 

  Chapman, Patrick Martin (2022)

  N-Vinyltrialkylammonium and N-vinylimmonium tetrafluoroborate salts are novel classes of compounds discovered by Buszek and Jung. They were originally used as dienophiles and as ß-dialkylamino equivalents in Diels-Alder ...

• Electrochemical Analysis of Oxidation of Primary Amines to Ketones with 3,5-Di-Tert-Butyl-1,2Benzoquinone 

  Mumau, Matthew Ray (2022)

  Electrochemical techniques have been used extensively to study electrode reactions and the coupled chemical-electrochemical reactions. Moreover, the concentration of redox active species in many of the redox reactions ...

• Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus 

  Sharma, Amar Deep (2022)

  Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis ...

• Chemical and biochemical applications of vibrational spectroscopy 

  Brenner, Reid Ethan (2022)

  Vibrational spectroscopy is a technique that probes a molecule’s vibrational modes via infrared absorption and Raman scattering, and is often used as a tool for characterization and/or functional group determination. Because ...

• Ab Initio Density Functional Theory Charge Distributions of Vinyltrimethylphosphonium, Vinylphosphorinium, and Vinyldiphosphonium Tetrafluoroborate Salts with Mechanistic Studies of Phospha-Michael Additions to Activated Acetylenes 

  Taber, Jacob Daniel (2022)

  While vinylammonium and vinylpyridinium tetrafluoroborate salts have previously been well investigated by the Buszek research group in their applications to Diels-Alder and other reactions, very little is known about their ...

• Peptide-Based Platform For Cancer Therapeutics And Drug Transportation Across Blood-Brain Barrier 

  Barve, Ashutosh (University of Missouri -- Kansas City, 2018)

  Prostate cancer is the most common male malignancy and remains the second-leading cause of death due to cancer in American men. While surgery and radiation are effective in prostate cancer therapy at early stages, the ...

• Hydrolysis and aqueous corrosion of silicate and aluminosilicate glasses via ab initio molecular dynamics simulation 

  Baral, Khagendra (2021)

  Hydrolysis and aqueous corrosion of glass is a complex and puzzling phenomenon. Although many endeavors have been made to investigate corrosion in glass, it is still an open question with many unanswered fundamental issues. ...

• Aminoxyl Catalyzed Electrochemical Ethanol Detection: Development of a New Breathalyzer Using Molecular Catalysis 

  Mayer, Mikayla Noelle (2021)

  Blood alcohol concentration (BAC) is the indicator of alcohol intoxication, and its measurement has emerged as the most common analytical procedure requested by law enforcement. Due to its volatility, ethanol vapor can be ...

• Smart hydrogel for enzyme responsive vaginal delivery of anti-HIV peptide therapeutics 

  Yeruva, Taj (2021)

  In response to an urgent need for advanced formulations for the delivery of anti-retrovirals, a stimuli sensitive hydrogel formulation that intravaginally delivers HIV-1 entry inhibitor upon being exposed to a specific ...

• Novel nanocarriers to improve drug delivery for age-related macular degeneration 

  Sikder, Sadia (2021)

  Visual impairment affecting the posterior segment of the eye is a significant health problem causing a deterioration of the quality of life of millions worldwide. Age-related macular degeneration (AMD) is ranked third on ...

• Enhanced Etoposide Solubility and Anticancer Activity using Complexation and Nanotechnology 

  Alsalhi, Abdullah (2021)

  Etoposide is a first line treatment for different cancer types that can be used either alone or in combination with other therapeutic agents. However, systemic toxicity, variable oral bioavailability, and high drug resistance ...

• Chirality directed self-assembly: in situ construction of recyclable and reusable Janus dendrimers 

  Zhou, John (2021)

  The underlying theme at the forefront of synthetic organic chemistry has always been about compounding simple precursors into more complex molecular targets. However, this strenuous process often involves the generation ...

• Amorphous hydrogenated boron carbide for solid-state direct-conversion thermal neutron detection 

  Bhattarai, Gyanendra (2021)

  Amorphous hydrogenated boron carbide (a-BC:H) is one of a very limited number of neutron-sensitive materials. It has been studied over the last three decades for solid-state thermal neutron detection due to its high ...

• Development of Targeted siRNA Therapeutics for Triple Negative Breast Cancer and Liver Fibrosis 

  Zhao, Zhen (University of Missouri -- Kansas City, 2018)

  The objective of this dissertation is to develop various systems to deliver small interfering RNA (siRNA) for the treatment of triple negative breast cancer (TNBC) and liver fibrosis. siRNAs targeting vascular endothelial ...

• Evaluation of the Anti-Fibrotic Activity of PCBP2 siRNA in Primary Hepatic Stellate Cells and Discovery of Anti-PD-L1 Peptide and Nanobody for Immunotherapy 

  Liu, Hao (University of Missouri -- Kansas City, 2018)

  There are two major research objectives in this dissertation. Our laboratory recently discovered a small interfering RNA (siRNA) that silences the poly (rC) binding protein 2 (PCBP2) gene. It is hypothesized that silencing ...

• Metabolomics and chemical library screening for antibacterial drug discovery 

  Ayon, Navid Jubaer (2020)

  There are twenty standard amino acids which are proteinogenic and can exist in two stereoisomeric forms, D- and L-enantiomers, except for glycine, which is achiral. The D-amino acids are not incorporated in proteins; ...

• Ab Initio Study of Amorphous Zeolitic Imidazolate Framework (A-ZIF) and Pyrophosphate crystals 

  Adhikari, Puja (2020)

  Zeolitic imidazolate frameworks (ZIFs) are a rapidly emerging class of versatile porous material with many potential applications. Here, we report the construction of an amorphous ZIF (a-ZIF) model from a near-perfect ...

• Second Generation Photoactivated Insulins 

  Nadendla, Venkata Srikrishna Karthik (2020)

  The photoactivated depot (PAD) is a minimally invasive approach developed for a continuously variable light stimulated release of insulin. In this approach, a protein depot that can last for days is injected under the skin. ...

• Development of Nanomedicine to Simultaneously Target Pancreatic Cancer Cells and Stroma 

  Li, Yuanke (2020)

  Dense desmoplastic stroma is a fundamental characteristic of pancreatic ductal adenocarcinoma (PDAC) and comprises up to 80% of the tumor mass, which acts as a barrier that impedes the delivery of antitumor drugs into the ...

• Topical Clear Aqueous Nanomicellar Formulations for Age-Related Macular Degeneration 

  Alshamran, Meshal (2020)

  Disorders affecting the posterior segment of eyes represent a significant burden to healthcare and patients’ wellbeing. Among the back of the eye disorders, age-related macular degeneration (AMD) is one of the major ailments ...

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