Department of Chemistry (UMKC)
The Department of Chemistry offers programs of study leading to the bachelor of arts (B.A.), bachelor of science (B.S.), and master of science (M.S.) degrees, and participates in UMKC’s interdisciplinary Ph.D. program. The department has about 30 interdisciplinary Ph.D. students, 10 master students and over 220 undergraduate chemistry majors. Graduate students can specialize in the traditional fields of analytical, inorganic, organic, physical, or polymer chemistry.
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Toward high thermoelectric performance of solids: ab initio forces within the orthogonalized linear combination of atomic orbitals method
(2024)Toward the long-term goal of predicting the figure of merit of complex thermoelectric materials, we introduce the computational and theoretical groundwork for the calculation of interatomic forces in ab initio calculations ... -
Medieval seismicity on the Himalayan Frontal Thrust Fault at Lal Dhang, Uttarakhand, India
(2019)The Himalayan Frontal Thrust Fault (HFT) lies at the active, tectonic boundary between Eurasia and the Indian subcontinent. Continuous convergence between the landmasses causes strain to accumulate on the fault, which is ... -
Advancing the treatment of relativistic theory within the OLCAO package and with application to solar photovoltaic technologies
(2024)Methylammonium lead bromide, known as CH3NH3PbBr3, is a promising perovskite material for the absorption layer in solar cells. While its bulk electronic structure is favorable, its long-term stability and interface design ... -
Exploring multivalency and chemical modifications in the development of anti-PD-L1 peptide inhibitors for cancer immunotherapy
(2023)The PD-1/PD-L1 immune checkpoint axis is one of the most common pathways exploited by cancers to evade immune surveillance. Many cancers overexpress PD-L1 (programmed cell death ligand 1) on their surface through which ... -
Investigation of process–structure–property correlations for plasma-enhanced chemical vapor deposited complex disordered solids: towards data-driven computational materials design
(2023)Complex disordered solids, characterized by multicomponent, multiphase, sub-structured configurations, coupled with a lack of long-range order, represent an application-rich class of materials, exhibiting a vast number of ... -
Targeting extracellular matrix using siRNA for the treatment of liver fibrosis and pancreatic cancer
(2023)The objective of this dissertation is to develop peptide-based siRNA delivery systems for the treatment of liver fibrosis and pancreatic ductal adenocarcinoma (PDAC). We recently discovered that silencing the poly (rC) ... -
Development of Closomer And MIBG based Nanoformulation: Application to HIV Prevention and Neuroblastoma Therapy
(2023)This dissertation is divided into two parts. Part #1 focuses on the development and characterization of closomer based nanoformulation for the prevention of HIV/AIDS sexual transmission. Part #2 focuses on the development ... -
Design, Preparation, And Applications Of Novel N-Vinyliminium Salts in Organic Synthesis. Design and Synthesis of Tau Aggregate-specific Fluorescent Probes for Postmortem Imaging of Brains with Tauopathies
(2023)PART I Efforts to optimize the electrophilic coupling partners for the Suzuki reaction by electronically and sterically tuning the pyridinium moiety are described. Both reaction temperature and catalyst loading have been ... -
Library Screening and Focused Multiomics of Antibacterial Action on Vancomycin-Resistant Enterococci faecium
(2023)Antimicrobial resistance is a major public health threat, and there is an urgent need for new strategies to address this issue. In a gram-positive bacteria, the peptidoglycan layer is thick as compared to gram negatives ... -
Chemical strategies for improving anti-diabetic glucagon therapy
(2023)The pancreas functions to carry out one of the most critical functions in the human metabolism, viz. glucose homeostasis. It achieves homeostasis by producing hormones including insulin and glucagon which act on different ... -
Evaluation of the degradation of per- and polyfluoroalkyl substances (PFAS) using UV-activated silica-based granular media (UV/SGM)
(2023)Per- and polyfluoroalkyl substances (PFAS) have become ubiquitous in the environment through production, industrial use, and consumer use. PFAS are recalcitrant, persistent, and bioaccumulative contaminants of concern which ... -
Chemical Surface Modification of Polycarbonate to Increase Hydrophilicity
(2023)Polycarbonate, commonly used in glasses lenses, is prone to fogging. Fogging can be reduced by modifying the structure of polycarbonate to be more hydrophilic, ideally superhydrophilic with a contact angle less than 10°. ... -
Development and Evaluation of 3D-Printed Cardiovascular Stents
(2022)Biodegradable stents (BDS) could be a promising alternative to the conventional metallic stents for the treatment of atherosclerosis which is a coronary artery disease (CAD). Three-dimensional (3D) printing technique has ... -
Ab Initio Density Functional Theory Optimized Geometries of Vinyl Trialkylammonium, Vinylpyridinium and Vinyldiazonium Tetrafluoroborate Salts with Natural Bond Orbital Charge Distributions in the Gas Phase
(2022)N-Vinyltrialkylammonium and N-vinylimmonium tetrafluoroborate salts are novel classes of compounds discovered by Buszek and Jung. They were originally used as dienophiles and as ß-dialkylamino equivalents in Diels-Alder ... -
Discovery and delivery of peptide-based immune checkpoint inhibitors targeting Pd-L1 for cancer immunotherapy
(2022)The objective of this dissertation is to develop peptide-based immune checkpoint inhibitors that block the interaction between programmed cell death ligand-1 (PD-L1) and its receptor programmed cell death protein 1 (PD-1) ... -
Electrochemical Analysis of Oxidation of Primary Amines to Ketones with 3,5-Di-Tert-Butyl-1,2Benzoquinone
(2022)Electrochemical techniques have been used extensively to study electrode reactions and the coupled chemical-electrochemical reactions. Moreover, the concentration of redox active species in many of the redox reactions ... -
Cell wall metabolite levels as a function of the growth phase in Staphylococcus aureus and library screening for synergistic combinations of FDA approved drugs against methicillin resistant S. aureus
(2022)Liquid chromatography-tandem mass spectrometry (LC-MS/MS) based methods for quantifying cell wall biosynthesis intermediates. These include LC-MS/MS methods for quantifying cytoplasmic UDP-linked peptidoglycan biosynthesis ... -
Chemical and biochemical applications of vibrational spectroscopy
(2022)Vibrational spectroscopy is a technique that probes a molecule’s vibrational modes via infrared absorption and Raman scattering, and is often used as a tool for characterization and/or functional group determination. Because ... -
Discovery of Anti-CD47 Peptides for Cancer Immunotherapy and CD47-mimicking Peptides That Inhibit Phagocytic Clearance of Nanoparticles
(2022)In the last few decades cancer immunotherapy has emerged as a standard pillar of cancer treatment. Immune checkpoint inhibitors that are currently available target the adaptive immune system, generating T-cell antitumor ... -
Ab Initio Density Functional Theory Charge Distributions of Vinyltrimethylphosphonium, Vinylphosphorinium, and Vinyldiphosphonium Tetrafluoroborate Salts with Mechanistic Studies of Phospha-Michael Additions to Activated Acetylenes
(2022)While vinylammonium and vinylpyridinium tetrafluoroborate salts have previously been well investigated by the Buszek research group in their applications to Diels-Alder and other reactions, very little is known about their ...