Browsing Molecular Biology and Biochemistry Electronic Theses and Dissertations (UMKC) by Thesis Department "Pharmaceutical Sciences (UMKC)"
Now showing items 1-5 of 5
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Epigenetic Regulation Of The HIF Pathway And Novel Therapeutic Opportunities
(2014-08-28)The research presented in this dissertation is aimed at understanding the epigenetic regulation of the HIF pathway and the efficacy of treatment for retinal diseases and hemangioblastomas using HIF pathway inhibitors. ... -
Evaluation Of HIF Inhibitors For The Treatment of Ocular Neovascular Diseases
(2015-06-02)Hypoxia-inducible-factor (HIF)-mediated expression of pro-angiogenic genes under hypoxia is the fundamental cause of pathological neovascularization in ocular diseases and cancers. Thus, the inhibitors of the HIF pathway ... -
Functional Analysis of TET-Family 5-Methylcytosine Dioxygenases in Non-CpG DNA Demethylation
(2023)One of the most widely studied epigenetic marks in DNA is 5-methylcytosine (5mC). Research has indicated that in the mammalian genome around 5-6% of all cytosines are methylated (5mC), with a strong preference for the CpG ... -
Novel Dichloroacetate Prodrugs for Improved Targeting of Breast Cancer Chemotherapeutics
(University of Missouri -- Kansas City, 2019)It is well documented that most cancer cells utilize aerobic glycolysis or Warburg metabolism instead of mitochondrial oxidative phosphorylation for cell energy production. Dichloroacetate is a synthetic small molecule ... -
Novel in vitro cell culture models for studying pharmacokinetic drug-drug interactions following oral administration
(University of Missouri--Kansas City, 2011-09-21)In this study different in vitro models were developed to study the long term and short term drug- drug interactions occurring upon oral administration. MDCK cells were stably transfected for the simultaneous expression ...