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Now showing items 61-78 of 78
The role of CFTR in regulating the cell cycle of intestinal stem cells
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] [Abstract taken from public pdf.] Cystic fibrosis (CF) patients and CF mouse models have an increased risk for gastrointestinal (GI) cancer. Intestinal ...
Role of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase in upregulation of intermediate-conductance Ca[superscript 2+] -activated K[superscript +] channels (K[subscript Ca]3.1) associated with atherosclerosis
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] A key risk factor for the development of atherosclerosis is familial hypercholesterolemia (FH), a genetic disease characterized by elevated levels of ...
FAST kinase domain-containing protein 1 in mitochondrial function, cell death and cardiovascular disease /
(University of Missouri--Columbia, 2016)
Cell death occurs during myriad circumstances and varied physiological and pathological conditions. Identifying novel modulators of cell death pathways is crucial to understanding and controlling cell death. Therefore, we ...
Development of a motor unit number estimation technique in normal dogs : a potential biomarker for canine degenerative myelopathy
(University of Missouri--Columbia, 2011)
Motor unit number estimation (MUNE) is an electrophysiologic technique for quantifying the lower motor neuron (LMN) system. MUNE has proven useful in evaluating and monitoring neurodegenerative diseases such as amyotrophic ...
Effects of adrenoreceptor activation and aging on skeletal muscle arterioles at rest and during rapid onset vasodilation
(University of Missouri--Columbia, 2010)
Sympathetic nerve activity (SNA) induces arteriolar vasoconstriction via [alpha]-adrenoreceptor ([alpha]AR) activation. Whether [alpha]AR activation affects the spread of rapid onset vasodilation (ROV) in contracting muscle ...
Double pelvic osteotomy for the treatment of hip dysplasia in dogs
(University of Missouri--Columbia, 2011)
Canine hip dysplasia (CHD) is the most common developmental orthopedic disease of dogs. Triple pelvic osteotomy (TPO) is a surgery that can be performed at 5 months of age, prior to the development of osteoarthritis. ...
Tavocept (BNP7787) : a novel chemoprotector/sensitizer and radioprotector/sensitizer
(University of Missouri--Columbia, 2011)
Introduction: Tavocept is a novel chemoprotector/ sensitizer that has been used in combination with cisplatin to treat adenocarcinomas. The objectives of this study were to evaluate the interaction of radiation and Tavocept ...
Comparison of an inertial sensor based system of lameness quantification to subjective lameness evaluation
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Recently developed wireless inertial sensor systems provide a means to objectively detect lameness as a horse is trotted over natural footing. The ...
Cytauxzoon felis : an emerging feline pathogen and potential therapy
(University of Missouri--Columbia, 2011)
Cytauxzoon felis is a pathogenic hemoprotozoal parasite of Felidae. We were able to document, via both piroplasm detection and PCR analysis, a chronic carrier state in naturally infected captive bred tigers as well as ...
Cholesterol synthesis inhibitors prevent growth and metastasis of breast cancer cells
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Clinical trials and studies show that post-menopausal women undergoing hormone replacement therapy containing a combination of estrogen and progestin ...
Studies on contagious abortion
(University of Missouri--Columbia, 1918)
Text from Introduction: "This thesis includes a review of the more important literature relating to contagious abortion or infectious abortion that was available, and particularly that dealing with experimental researches ...
The effect of sodium/hydrogen exchanger inhibition on chemotherapy-induced intestinal epithelial damage
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The small intestinal epithelium is one of the most rapidly dividing tissues in the mammalian body, making it an inadvertent target of non-specific ...
The molecules that move us : evaluating potential genetic and molecular determinants of physical activity motivation
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Physical activity is at the basis of human history. The fact that we occupy every continent, were built for long distance travel, and that we find ...
A projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarii is critical for cardiorespiratory responses to hypoxia
(University of Missouri--Columbia, 2019)
The arterial chemoreflex is an essential protective mechanism for adaptive responses to hypoxia. Stimulation of peripheral chemoreceptors initiates a reflex response that generates compensatory physiological responses, ...
Effect of induced hindlimb length difference on bodymounted inertial sensor measures of hindlimb lameness in horses
(University of Missouri--Columbia, 2019)
This study has investigated the effect of induced hindlimb length difference on differences in minimum and maximum pelvic heights in horses trotting in a straight line and lungeing on both hard and soft surfaces. The horses ...
A reversal of fate : unravelling the role of central 5-HT in cardiorespiratory control in neonatal and adult rodents
(University of Missouri--Columbia, 2018)
We seek to address the extent to which a specific loss of 5-hydroxytryptamine (5-HT) affects the control of respiration, arterial blood pressure (ABP) and heart rate (HR) across vigilance-states based on existing evidence ...
Comparison of left 4th and 5th intercostal space thoracotomy for open-chest cardiopulmonary resuscitation in dogs
(University of Missouri--Columbia, 2018)
Open-chest cardiopulmonary resuscitation (OC-CPR) is indicated in certain cardiopulmonary arrest situations such as thoracic trauma. Laboratory research and clinical studies in human medicine have established the superiority ...
Neurokinin-1 antagonism as a novel treatment for feline asthma : investigation of the role of substance p in airflow limitation and airway inflammation
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Feline asthma, a chronic respiratory condition, results cough and/or episodic respiratory distress induced by airway hypperresponsiveness (AHR), airway ...