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Novel macrocyclic compounds as building blocks in supramolecular chemistry
(University of Missouri--Columbia, 2010)
Resorcinarenes and pyrogallolarenes have been widely used as building blocks for novel synthetic receptors and supramolecular self-assemblies. To explore new chemistry of these compounds, new substituted macrocyclic arenes ...
Energy transfer at gas-liquid interface : towards energetic materials
(University of Missouri--Columbia, 2007)
Physicochemical surface processes have great importance in the different fields of everyday life and science. Computational characterization of collisional energy transfer at a gasliquid interface is a helpful tool to ...
Determination of total selenium and seleno-amino acids in yeast and aquatic organisms by liquid chromatography and inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2007)
The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...
Studies of the chemistry of Tröger's base, cyclopentadienones, and 2,1-benzothiazines
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The sequential alkylation of Tröger's base was developed for the synthesis of symmetric dialkylation analogs. The products from this reaction were ...
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)
Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...
Stereoselective synthesis of seven-membered rings using intramolecular (4+3) cycloaddition reactions
(University of Missouri--Columbia, 2020)
Heterocyclic molecules containing seven-membered rings have importance in organic synthesis owing to their presence in some natural products and biologically active molecules. Furthermore, these scaffolds act as important ...
Organo nickel and platinum chemistry at the edge of corannulene
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corannulene (C[subscript 20]H[subscript 10]), a polycyclic aromatic hydrocarbon (PAH) is a bowl shaped fullerene fragment. This work involves investigations ...
Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ...
Novel insights into strand cleavage at an abasic site in DNA
(University of Missouri--Columbia, 2022)
Loss of a nucleobases from the deoxyribose backbone of DNA generates Abasic sites in DNA. Abasic sites are the most common unavoidable DNA damage lesion. It is important to understand the properties of Abasic site. The ...
Intermolecular (4+3) cycloaddition reaction of oxidopyridinuim ions with silylated dienes, exploring the oxidation chemistry and photochemistry of cycloadducts
(University of Missouri--Columbia, 2022)
The development of endo/exo selectivity of intermolecular (4+3) cycloaddition reactions of an N-methyl oxidopyridinium ion has been studied. Dienes that contain silyl groups, R-groups, and contain both silyl group and ...
Advancing Uranium(III) reductive chemistry through hetroleptic metallocene aryloxide ligand frameworks
(University of Missouri--Columbia, 2023)
This dissertation looks at the reductive chemistry of Uranium (III)bis- pentamethylcyclopentadienyl arylox-ide complexes. For chapter two, the reactivity of two metallocene aryloxide U(III) complexes, [(C5Me5)2U(O-Ar)], R ...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and ...
Determination and analysis of multiphoton excitation emissive species.: I,: Emission of PAHS in acidic medium,: II,: Multiphoton emission of possible PDT agents
(University of Missouri--Columbia, 2005)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The exploitation of ultrafast laser properties has been recently increasing. Recent research in this lab demonstrated the ability of femtosecond pulses ...
Synthesis and reactivity of low-valent uranium and neptunium complexes
(University of Missouri--Columbia, 2019)
Chapter 1 reports the synthesis and characterization of U(IV) and Np(IV) selenium bis(phenolate) complexes. The reaction of the U(IV) complex with half an equivalent of p-benzoquinone results in the formation of a U(V)--U(V) ...
The separation of vanadium from crude sodium uranate and conversion of latter into uranium oxide
(University of Missouri--Columbia, 1915)
The experiments here described have resulted in at least four methods that have proven successful for removal of vanadium from the crude urinate, which is obtained on a large scale in the plant of the National Radium Institute.
Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Integrated multidimensional liquid chromatography (IMDLC) is an innovative method used for separation of tryptic peptides. In this method a two-component ...
Anisotropic organic materials : ferroelectric crystals and spin-polarized radicals
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Anisotropic organic materials are attracting increasing interesting for their highly electro-optic characteristics. We are especially interested in ...
The effects of structural modifications on sigma receptor binding
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family that has two subtypes: sigma1 and sigma2. Sigma1 receptors are involved in several physiological functions such as psychosis and depression. Sigma2 receptors are expressed in ...
Investigations into the chemistry of protein tyrosine phosphatase redox regulation
(University of Missouri--Columbia, 2009)
Transmission of complex intracellular signals, such as those for glucose uptake or proliferation, is often accomplished through the reversible phosphorylation of specific protein tyrosine residues. This reversible ...
Synthethic pathways to multiple surface functionalization of polyhedral boranes
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The chemistry of dodecahydro--closo--dodecaborate(2-), closo-[B12H12]2-, and decahydro-closo-decaborate(2-), [B10H10]2-, with different organic ...