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Four-limb IMU sensors for canine gait analysis
(University of Missouri--Columbia, 2019)
Canine models of human musculoskeletal diseases, such as Duchenne muscular dystrophy (DMD), are important translational animal models for developing therapies. Musculoskeletal diseases alter gait performance, and gait ...
Development of a biosensor for the detection of Helicobacter hepaticus utilizing multi-functioning immobilization platforms
(University of Missouri--Columbia, 2010)
Optical biosensor development is a process involving the careful selection of the material for the immobilization platform, design of the detection mechanism and integration with optical and electronic equipment. The ability ...
Amyloid- [beta] peptide induces temporal membrane biphasic changes in astrocytes through cytosolic phospholipase A₂
(University of Missouri--Columbia, 2010)
Oligomeric amyloid-[beta] peptide (A[beta]) is known to induce cytotoxic effects and damage cell functions in Alzheimer's disease. However, mechanisms underlying the effects of A[beta] on cell membranes have yet to be fully ...
Manure management using precision agriculture
(University of Missouri--Columbia, 2010)
The overall purpose of this project was to develop and implement a manure application record system that was solely based on Global Positioning Systems (GPS). This system will have the ability to provide steering and ...
Molecularly imprinted polymer labeled with quantum dots for detection of nitroaromatic explosives
(University of Missouri--Columbia, 2010)
A sensing device for explosive compounds is a fundamental step towards the capability to detect the presence of landmines, improvised explosive devices (IEDs), and other unexploded ordinance. To detect high explosive ...
Applications of the opto-fluidic ring resonator for DNA methylation analysis and microfluidic laser development
(University of Missouri--Columbia, 2010)
For several decades, optical ring resonators have played an important role in the field of telecommunications. Within only the past decade however, ring resonators have been applied for the purposes of biological and ...
Integration of single-cell electropermeabilization together with electrochemical measurement of quantal exocytosis on microchips
(University of Missouri--Columbia, 2013)
An electrochemical microelectrode located immediately adjacent to a single neuroendocrine cell can record spikes of amperometric current that result from quantal exocytosis of oxidizable transmitter from individual vesicles. ...
CFTR chloride channels and ABC active transporters undergo similar structural rearrangements as part of their operation
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Defects in the cystic fibrosis transmembrane conductance regulator (CFTR) underlie the lethal genetic disease cystic fibrosis. Although CFTR belongs ...
Polyurethane foams made from bio-based polyols
(University of Missouri--Columbia, 2011)
Polyurethane (PU) foams have great applications in industry. The raw materials of PU, polyol and isocyanate, are conventionally derived from petroleum. Bio-based polyols are promising substitutes for petrochemical polyols ...
Electrospinning collagen and hyaluronic acid nanofiber meshes
(University of Missouri--Columbia, 2011)
Osteoporosis is a worldwide burden affecting over 200 million people. There are many risk factors associated with osteoporosis, but they all lead to decreased bone strength and an increased chance of bone fracture. The ...
Characterizing optical properties in fibrous tissues
(University of Missouri--Columbia, 2011)
Optical methods are promising for non-invasive tissue characterization. Biological tissues can be classified into isotropic tissues and anisotropic tissues. The optical properties of isotropic tissues such as adipose tissue ...
Direct-from-sputum rapid phenotypic drug susceptibility test for mycobacteria
(University of Missouri--Columbia, 2018)
The spread of multi-drug resistant tuberculosis (MDR-TB) is a leading global public-health challenge. Because not all biological-mechanisms of resistance are known, culture-based (phenotypic) drug-susceptibility testing ...
Functional study of Kcv potassium channel through manipultion [sic] of individual subunits
(University of Missouri--Columbia, 2010)
Potassium channels make up a ubiquitous, physiologically essential class of integral membrane proteins. Many K+ channels contain four identical symmetrically associated subunits. To explore the role of an individual subunit ...
Deletion of IP₃ receptor2 in astrocytes enhances the hippocampal neurogenesis in adult mice
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Neurogenesis (birth of neurons) is a process by which neurons are generated from neural progenitor cells. It mainly occurs in two regions of brain, one ...
Development and characterization of gold nanoparticle-collagen scaffold
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Collagen is considered a versatile biological material for soft tissue application, owing to its excellent biocompatibility. However in its purified ...
Polyurethane foams containing renewable castor oil replacement
(University of Missouri--Columbia, 2014)
Polyurethane foams have a wide variety of commercial applications in daily life due to their unique advantages. Traditionally, polyurethane foams are made from petroleum-based polyols and isocyanates. Due to the shortage ...
Development of gold nanoparticle conjugated polyethylene terephthalate for improved biocompatibility in hernia repair materials
(University of Missouri--Columbia, 2010)
Synthetic biomaterials are currently a popular choice for use in many surgical soft tissue repair applications. Polyethylene terephthalate (PET) is an example of such material that has been used, more specifically, for ...
Rapid isolation of target bacteria from complex matrices
(University of Missouri--Columbia, 2010)
The long term goal of the research effort in our group was to develop a new rapid diagnostic process for sepsis. The specific project described in this work aims to obtain these "pure" isolates of the infectious bacteria ...
Ion transport modeling for retinal rod photoreceptor cells
(University of Missouri--Columbia, 2010)
In this study, a mathematical model is developed to describe the ion transport activities associated with the response of rod photoreceptor to light stimulus. In the model, the cell body is modeled as two capacitors connected ...
Photoacoustic evaluation of surfaces via pulsed evanescent field interaction
(University of Missouri--Columbia, 2014)
In recent years, major research funding and commercial development has been going toward the production and characterization of increasingly useful nanomaterials. These materials such as quantum dots, nanoparticles, and ...