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Complex microbiota targeted rederivation (CMTR) as an alternative method to study effect of gut microbiota on host physiology /
(University of Missouri--Columbia, 2016)
Rodent models are invaluable tools to study the effects of differing gut microbiota (GM) on health and disease. Our laboratory has demonstrated that mouse GM profiles vary among animal vendors suggesting that subtle ...
Restriction of HIV by TIM-family proteins and antagonism by NEF /
(University of Missouri--Columbia, 2016)
Transcriptome profiling of rattus norvegicus embryonic stem cells by RNA-sequencing
(University of Missouri--Columbia, 2014)
Embryonic Stem Cells (ESCs) are a critical tool for producing targeted knockout animals and understanding development. ESCs were successfully isolated from rats in 2008 and have been used in producing several targeted ...
Discovering disease causing variants in dogs through whole genome sequencing
(University of Missouri--Columbia, 2017)
This dissertation focuses on the use of whole genome sequencing (WGS) for the identification of disease causing variants in canine genomes. A brief review on the historical milestones of genetics, the creation and ...
Yersinia pestis YopJ, YopT, and YopK coordinate programmed cell death and cytokine responses to promote pneumonic plague
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Yersinia pestis has been responsible for three major pandemics of plague, including the infamous Black Death that killed 250 million people in Europe. ...
Investigation of novel therapeutic strategies for attenuating corneal fibrosis
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Corneal fibrosis (scarring) is a significant cause of vision loss worldwide resulting from an exuberant wound healing response driven in part by the ...
Development and characterization of a novel meniscal extracellular matrix-derived scaffold /
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Musculoskeletal injuries are a common and significant problem in orthopaedic practice. Despite advances in orthopaedic surgery, effective treatments ...
Intermedilysin-mediated cell ablation in the rat and zebrafish
(University of Missouri--Columbia, 2016)
Current methodologies of cell ablation have limitations with respect to the types of cells that can be targeted, the lack of specificity of ablation and the lack of appropriate methodologies to facilitate their use across ...
Inflammatory and cardiac response to end-stage pneumonic plague
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Yersinia pestis is the etiologic agent of pneumonic plague, a devastating disease in humans characterized by acute bronchopneumonia that is frequently ...
Assessment of biomarker production by osteoarthritic osteochondral tissues and correlation to the biomechanical, biochemical, and histological properties
(University of Missouri--Columbia, 2016)
Osteoarthritis (OA) is the most prevalent form of arthritis and is a significant cause of pain and disability worldwide. Treatment options available are only capable of controlling symptoms until progression to end-stage ...
Microbiota modulation of behavior and stress responses : implications for neuro-immune research in zebrafish
(University of Missouri--Columbia, 2016)
The gut microbiota (GM) consists of a large microbial community whose collective set of genes encodes a vast array of functions. These microbes play a major role in many physiological processes within the host and are ...
Dietary nutrients implicated in the etiopathogenesis of human and animal diseases
(University of Missouri--Columbia, 2017)
Hyperthyroidism is a spontaneous disease that results in an abnormal elevation of circulating concentrations of one or more thyroid hormones. Despite being the most commonly diagnosed endocrine disorder of domestic cats, ...
Examine the role of minor splicing pathway in spinal muscular atrophy
(University of Missouri--Columbia, 2014)
Spinal Muscular Atrophy (SMA) is an autosomal recessive disorder mainly caused by deletions or mutations of one gene, Survival Motor Neuron (SMN). SMN is crucial in splicing processes for proper gene expression. Previous ...
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
(University of Missouri--Columbia, 2013)
Inflammatory bowel disease (IBD) is one of the most common immune-mediated diseases in the United States costing the average patient tens of thousands of dollars annually, and greatly diminishing quality-of-life. While ...
Defining the therapeutic window in spinal muscular atrophy :time points study
(University of Missouri--Columbia, 2013)
Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. ...
Mapping the language-specific cerebrocerebellar network of the human brain through diffusion tensor imaging
(University of Missouri--Columbia, 2015)
Language was arguably a key influence in the evolution of the human brain and the evolution of this behavior in humans was likely associated with gross morphological changes and novel neural networks. My dissertation looked ...
Biochemical characteristics of different subtypes of human immunodeficiency virus type 1 reverse transcriptase and its interactions with the host factor : apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3G
(University of Missouri--Columbia, 2017)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Human immunodeficiency virus (HIV) is divided into type 1 (HIV-1) and type 2 (HIV-2). Whereas HIV-2 accounts for 5% of global infections, HIV-1 is ...
Development of the human ex vivo split tissue osteoarthritis model
(University of Missouri--Columbia, 2017)
Osteoarthritis (OA) is a disease characterized by loss of functional articular cartilage with associated whole-joint pathology and resultant pain and disability, which is projected to affect 59.4 million Americans by 2020. ...
Cellular and molecular mechanisms underlying immune tolerance against type 1 diabetes /
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D), also known as insulin-dependent diabetes mellitus, is a chronic autoimmune disease caused by the destruction of insulin-producing ...
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)
Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ...