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What treatments relieve arthritis and fatigue associated with systemic lupus erythematosus?
(Family Physicians Inquiries Network, 2014)
to 70% of patients (SOR: b, systematic review of RCTs with limited patient-oriented evidence). Nonsteroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are often used for SLE joint pain (SOR: c, expert opinion). Omega-3 fatty acids may reduce...
Does any antidepressant besides bupropion help smokers quit?
(Family Physicians Inquiries Network, 2014)
Q: Does any antidepressant besides bupropion help smokers quite? Evidence-based answer: Yes, nortriptyline approximately doubles smoking cessation rates, an effect comparable to bupropion. Adding nortriptyline to nicotine replacement therapy (NRT...
What is the best nonsurgical therapy for pelvic organ prolapse?
(Family Physicians Inquiries Network, 2014)
Q. What is the best nonsurgical therapy for pelvic organ prolapse? Evidence-based answer: Pelvic floor muscle training (PFMT) and pessaries are equally effective in treating symptoms of pelvic organ prolapse (POP). PFMT transiently improves patient...
Is immediate-release topiramate an effective treatment for adult obesity?
(Family Physicians Inquiries Network, 2014)
Q: Is immediate-release topiramate an effective treatment for adult obesity? Evidence-Based Answer: Yes. Topiramate (at daily doses of 64-400 mg) produces an average 5.34 kg of additional weight loss compared with placebo (95% confidence interval...
An antiemetic for irritable bowel syndrome?
(Family Physicians Inquiries Network, 2014)
An antiemetic for irritable bowel syndrome? A drug used for cancer patients may provide some relief to patients with IBS. Practice changer: Consider prescribing ondansetron up to 24 mg/d for patients who have irritable bowel syndrome with diarrhea...
What is the best treatment for impetigo?
(Family Physicians Inquiries Network, 2014)
Q. What is the best treatment for impetigo? A. Although evidence is lacking to support a single best treatment for impetigo, topical mupirocin, fusidic acid, gentamicin, and retapamulin are all at least 20% more likely than placebo to produce cure...
Which risk factors and signs and symptoms are associated with coccidioidomycosis?
(Family Physicians Inquiries Network, 2014)
Q: Which risk factors and signs and symptoms are associated with coccidioidomycosis? Evidence-Based Answer: Risk factors for coccidioidomycosis, or valley fever, include lower respiratory tract symptoms lasting longer than 14 days, chest pain, rash...
Apolipoproteins for Cardiovascular Risk Assessment
(Family Physicians Inquiries Network, 2014)
Clinical Question: Is measurement of apolipoproteins better than traditional lipid measurements for predicting cardiovascular risk? Evidence-Based Answer: Measurement of apolipoprotein B and apolipoprotein A-I is no better than traditional lipid...
Finally, a way to relieve cancer-related fatigue
(Family Physicians Inquiries Network, 2014)
A 4-week course of American ginseng, taken while patients are undergoing radiation or chemotherapy, can reduce cancer-related fatigue. PRACTICE CHANGER: Recommend American ginseng 1000 mg twice daily for 4 weeks to improve cancer-related fatigue...
Skip the compression stockings following DVT
(Family Physicians Inquiries Network, 2014)
Although commonly used, compression stockings do not effectively prevent post-thrombotic syndrome. Practice changer: Do not recommend elastic compression stockings (ECS) to decrease the incidence of post-thrombotic syndrome (PTS) after deep vein...
What are the benefits and risks of inhaled corticosteroids for COPD?
(Family Physicians Inquiries Network, 2014)
Q: What are the benefits and risks of inhaled corticosteroids for COPD? A: Inhaled corticosteroids (ICS), either alone or with a long-acting [beta] agonist (LABA), reduce the frequency of exacerbations of chronic obstructive ...
How do hydrochlorothiazide and chlorthalidone compare for treating hypertension?
(Family Physicians Inquiries Network, 2014)
reduction (strength of recommendation [SOR]: B, conflicting network meta-analysis and cohort studies). (No head-to-head studies of hydrochlorothiazide [HCTZ] and chlorthalidone have been done.) Serious hypokalemia and hyponatremia can occur with either...
Is there a primary care tool to detect aberrant drug-related behaviors in patients on opioids?
(Family Physicians Inquiries Network, 2014)
Of the several screening instruments developed and originally validated in patients in a pain center population (TABLE), one also has been validated in primary care. The Current Opioid Misuse Measure (COMM) predicts aberrant ...
Prolotherapy: A nontraditional approach to knee osteoarthritis
(Family Physicians Inquiries Network, 2014)
Recommend prolotherapy for patients with knee osteoarthritis (OA) that does not respond to conventional therapies.
Which prophylactic therapies best prevent gout attacks?
(Family Physicians Inquiries Network, 2014)
Q. Which prophylactic therapies best prevent gout attacks? A. Allopurinol and febuxostat reduce the frequency of gout attacks equally after 8 weeks of treatment (strength of recommendation [SOR]: B, multiple randomized ...
Can yoga reduce symptoms of anxiety and depression?
(Family Physicians Inquiries Network, 2014)
Q. Can yoga reduce symptoms of anxiety and depression? A. Yes, yoga can reduce symptoms of anxiety and depression (strength of recommendation [SOR]: B, systematic reviews of randomized controlled trials [RCTs] with significant ...
How can we effectively treat stress urinary incontinence without drugs or surgery?
(Family Physicians Inquiries Network, 2014)
Q. How can we effectively treat stress urinary incontinence without drugs or surgery? A. Pelvic floor muscle training (PFMT) and intravaginal electrical stimulation seem to be the best bets. PFMT increases urinary continence ...
Are topical nitrates safe and effective for upper extremity tendinopathies?
(Family Physicians Inquiries Network, 2014)
Q. Are topical nitrates safe and effective for upper extremity tendinopathies? A. Topical nitrates provide short-term relief with some side effects, especially headache. Topical nitroglycerin (NTG) patches improve subjective ...
The European Coexistence Bureau : Five Years' Experience
(University of Missouri, College of Agriculture, Food and Natural Resources, 2014)
The European Coexistence Bureau (ECoB) was established in 2008 to help European Union member states identify best practices for technical segregation measures between GM and non-GM crops and, on these bases,develop guidelines for crop...
Do oral contraceptives carry a significant risk of stroke for women with migranes?
(Family Physicians Inquiries Network, 2013)
Evidence-based answer: Estrogen-containing oral contraceptives may raise the risk of ischemic stroke in women with migraine, particularly migraine with aura (strength of recommendation [SOR]: C, small case-control studies with methodological flaws...