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Posttranscriptional gene regulation by the RNA binding protein HuR in two disease models : allergic asthma and breast cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The RNA binding protein HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their ...
Gene replacement restores the contractile and passive properties of skeletal muscle in murine models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a lethal disease caused by the loss of the dystrophin protein. Loss of mobility is a key clinical presentation in ...
Gene therapy in mouse models of spinal muscular atrophy :using SMN gene replacement to address biological questions
(University of Missouri--Columbia, 2013)
Spinal Muscular Atrophy (SMA), an autosomal recessive neuromuscular disorder, is the leading genetic cause of infant mortality. SMA is caused by the functional, homozygous loss of the Survival Motor Neuron-1 (SMN1) gene ...
The roles of ERK pathway localization and the regulation of [beta]-catenin/Bcl-XL kinetic in thymic selection
(University of Missouri--Columbia, 2011)
Thymocytes undergo a process of development that serves to favor the differentiation of T-cells bearing self-MHC (major histo-compatibility complex) restricted T-cell receptors (TCR). Signaling through the TCR is crucial ...
The RNA binding protein HuR : novel mouse models and T cell targets
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Posttranscriptional gene regulation is an important mechanism of controlling mRNA expression and protein production. The RNA binding protein has been ...
Identification and characterization of Bacillus anthracis spore-associated proteins
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bacillus anthracis is a Gram-positive, rod-shaped, spore-forming bacterium and the etiological agent of anthrax. Spore formation is essential for ...
The effects of toll-like receptor ligand-activated dendritic cells on human CD4⁺T cell responses
(University of Missouri--Columbia, 2008)
Dendritic cells (DCs) play an important role as a link between innate and adaptive immunity through their abilities to detect infection and to prime naïve T cells (signal 1 and 2). They not only activate naïve T cells, ...
Regulating the regulators : using CD25 depletion to enhance immune responses to a model plasmid-based vaccine
(University of Missouri--Columbia, 2008)
Due to their ease of production and safety, plasmid-based vaccines have become prime candidates for both prophylactic and therapeutic human vaccination. In experimental animal models, vaccination with plasmid DNA expression ...
An essential role in germline development for a P-granule associated novel protein in the model organism Caenorhabditis elegans and RNAi in the ubiquitous parasitic nematode Ascaris suum
(University of Missouri--Columbia, 2009)
The germline RNA helicases (GLHs) are constitutive components of P granules and important for fertility in C. elegans. Discovered as a GLH-1 partner, the P-granule associated novel protein (PAN-1) is important both in ...
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ...
Development of genome-wide genetic assays in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2015)
Illumina sequencing and other massively-parallel, short read sequencing technologies have become prevalent methods for querying the genetic systems of organisms. This trend was initially driven by the demand for general ...
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
(University of Missouri--Columbia, 2013)
Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are ...
Within and beyond immunomodulatory strategies against autoimmune diabetes : antigen-specific tolerance and endothelial regeneration
(University of Missouri--Columbia, 2013)
Type 1 diabetes (T1D) is a chronic disorder in which the cells of the immune system mediate selective destruction of the insulin-producing [beta]-cells in the islets of Langerhans in the pancreas. CD4+ effector T cells, ...
Factors contributing to humoral immunity against pneumonic plague
(University of Missouri--Columbia, 2012)
Yersinia pestis is the etiologic agent of plague and is responsible for more human deaths throughout history than any other bacterial pathogen. During infection bacteria inject effector proteins into target host cells using ...
Exploring modifiers in spinal muscular atrophy : the power of AAV9
(University of Missouri--Columbia, 2014)
The scaffold protein POSH regulates T lymphocyte function
(University of Missouri--Columbia, 2015)
T lymphocytes are critical mediators of the adaptive immune response. T cell receptor (TCR) mediated cJUN NH2-terminal kinase (JNK) activation is required for mounting proper T cell mediated immune responses. However, ...
Investigation of antiviral strategies targeting Human Immunodeficiency Virus Type I (HIV-1)
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] HIV-1 infection is currently treated with antiretroviral therapy. Three antiviral approaches were investigated to gain understanding on how HIV-1 can ...
Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
(University of Missouri--Columbia, 2015)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation by RNA-binding proteins such as HuR fine tunes gene expression in T cells leading to powerful effects on immune ...
Probing the viral replication of HCV and XMRV : biochemical characterization, inhibition kinetics and role of host proteins in viral replication
(University of Missouri--Columbia, 2015)
The studies described in this thesis focus on RNA viruses XMRV and HCV. In Chapter II we focused on Xenotropic Murine leukemia-Related Virus (XMRV). We characterized the biochemical activity and kinetics of the XMRV reverse ...
The Parvovirus Minute Virus of Mice modulates the DNA damage response to facilitate viral replication and a pre-mitotic cell cycle block /
(University of Missouri--Columbia, 2017)
The DNA damage response (DDR) is a critical cellular network that affords cells the ability to repair DNA damage they have incurred from endogenous and exogenous sources. Recently, it has become appreciated that viruses, ...