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Bayesian Change Point Analysis of Copy Number Variants Using Human Next Generation Sequencing Data
(2014)
Read count analysis is the principal strategy implemented in detection of copy number variants using human next generation sequencing (NGS) data. Read count data
from NGS has been demonstrated to follow non homogeneous ...
Analyzing the effects of Cis-elements and trans-factors on the stability of the Gal1 mRNP
(2014)
The highly dynamic and nonrandom spatial organization of the eukaryotic nucleus plays an important role in the regulation of gene expression. For example, in S. cerevisiae, several conditionally expressed genes relocate ...
Determining the differential roles of the dock family of GEFs in drosophila development
(2015-05-19)
The evolutionarily conserved Dock proteins function as unconventional guanine
nucleotide exchange factors (GEFs). Upon binding to ELMO (Engulfment and cell
motility) proteins, Dock-ELMO complexes activate the Rho family ...
Structure-function studies of the staphylococcal complement inhibitor protein family
(University of Missouri--Kansas City, 2012)
Complement is a primary arm of innate immunity that plays essential roles in clearance of microbial invaders and immune complexes, initiation of inflammation, development, and differentiation and serves as a bridge to the ...
3-Hydroxy-3-methylglutaryl-coenzyme A lyase: investigation of cysteines mediating intersubunit disulfide formation and regulation by thiol/disulfide exchange and discovery of an extramitochondrial homolog
(University of Missouri -- Kansas City, 2012-01-18)
3-Hydroxy-3-methylglutaryl-Coenzyme A lyase catalyzes the cleavage of 3-hydroxy-
3-methylglutaryl-Coenzyme A into acetoacetate and acetyl-Coenzyme A, a key reaction
in ketogenesis and leucine catabolism. Previous work ...
A proteomic approach for studying LTR retrotransposon host factors in saccharomyces cerevisae
(University of Missouri--Kansas City, 2012-01-20)
The Ty retrotransposons of S. cerevisiae are mobile elements that resemble retroviruses, both in their genetic structures and replication cycles. Ty retrotransposition begins in the nucleus with the transcription of Ty ...
The herpes simplex virus virion host shutoff protein is targeted to mRNA cleavage sites through interactions with components of the host translational apparatus
(University of Missouri--Kansas City, 2011-01-20)
The virion host shutoff protein (Vhs) is a herpes simplex virus (HSV) protein involved in early shutoff of the host cell. It is a component of the infecting virion, located in the tegument region, that works by rapidly ...
The Role of Host Translation Initiation Factors eIF4H and eIF4A and the Exon Junction Complex in the Control of mRNA turnover and Translation by the Virion Host Shut off Protein of Herpes Simplex Virus
(2013)
During lytic infections, the HSV Vhs endonuclease (UL41) degrades many viral and cellular mRNAs. This endonuclease activity is dependent upon the ability of Vhs to bind the host translation initiation factors eIF4AI/II and ...
Mating Type Specific Roles During The Sexual Cycle Of Phycomyces Blakesleeanus
(2014)
Phycomyces blakesleeanus is a filamentous fungus that belongs in the order Mucorales. It can propagate through both sexual and asexual reproduction. The asexual structures of Phycomyces called sporangiophores have served ...
Disconnecting a Role for DNA Repair in the Pathogenicity of the Human pathogen Cryptococcus neoformans
(2014)
C. neoformans is an opportunistic fungal pathogen causing fatal meningitis and lung infections. Worldwide every year around 625,000 deaths occur due to Cryptococcosis. A basic understanding of Cryptococcus virulence ...
Regulation of Gene Expression by Non-coding RNAs in Arabidopsis and Brachypodium
(2014)
Expansion of high-throughput sequencing technology has increased our understanding
in the importance of pervasive transcription and the resulting indispensable molecules, noncoding
RNAs (ncRNAs). A significant effort has ...
Independent Functions Of Clueless In Differential Integrin Secretion And Mitochondrial Quality Control In Drosophila Muscle
(2015)
Drosophila Clueless (Clu) and its conserved orthologs are known for their role in the prevention of mitochondrial clustering. Here, we uncover its independent roles in the delivery of integrin subunits and the regulation ...
The function of Drosophila Integrin-Dim7-Elmo-Mbc→Rac signaling pathway in the muscle attachment formation and maintenance
(2013)
The Engulfment and Cell Motility (Elmo)-(Myoblast city) Mbc→Rac signaling pathway is evolutionarily conserved from C. elegans to vertebrates and is essential for many developmental processes, including phagocytosis and ...
Structural Basis for the Formation of PTPRG•CNTN Complexes in Neural Tissues
(2016)
Receptor protein tyrosine phosphatase gamma (PTPRG) is a cell surface receptor expressed primarily on neurons. It combines cytoplasmic tyrosine phosphatase domains and an extracellular region that includes a carbonic ...
Biochemical and Structural Studies of the Role of FKBP(L)s in the fly and Mammalian Circadian Cycle
(University of Missouri -- Kansas City, 2017)
FK506 binding-like proteins (FKBPLs) are proteins that structurally resemble the
immunophilins. Their functions in cell signaling include protein folding, molecular trafficking,
RNA splicing and cell cycle regulation ...
A Genetic Screen for Tribbles Suppressors Identifies the E3 Ubiquitin Ligase Neuralized as a Novel Target
(University of Missouri -- Kansas City, 2017)
In this dissertation, I used the Drosophila wing as a model tissue for a genetic screen
to identify novel targets of Tribbles. Drosophila Tribbles is the founding member of a family
of pseudokinases conserved between ...
Hyper-Plastic Structural Evolution Of The PEX Domain - A Model Of Evolutionary Exaptation And Neofunctionalization At The Molecular Level
(University of Missouri--Kansas City, 2017)
With the advent of sophisticated genetic, biophysical and in silico technology an
enormous amount of information is being generated regarding the structural, biochemical and
physiological aspects of proteins. Tertiary ...
Regulation of Antimicrobial Peptide Genes in Insects by the Toll Pathway and NF-kB Transcription Factors
(University of Missouri--Kansas City, 2017)
Insects lack adaptive immunity and solely rely on innate immunity to combat
pathogens. Innate immunity in dipteran and lepidopteran insects mainly depends on two
canonical pathways, the Toll pathway that provides ...
Identification of a Novel Link between the Motor Proteins Dynein and Kinesin-1
(University of Missouri–Kansas City, 2016)
The motor proteins dynein and kinesin are fascinating biological machines which,
like vehicles in a city, move various cellular cargoes along cytoskeletal microtubules
(MT). In filamentous fungi, these motors are important ...
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)
Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ...