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Now showing items 41-60 of 64
Evolution, transmission, and clinical impacts of SARS-CoV-2 and influenza viruses
(University of Missouri--Columbia, 2023)
provided deeper insights into how an influenza and SARS-CoV-2 viruses emerge, evolve, and spread in humans and revealed how the intricate interplay between host, virus and environmental attributes affect disease severity of SARS-CoV-2 infection. Thus...
The validity of morphological features and osteological markers in reconstructing habitual activities
(University of Missouri--Columbia, 2007)
Bony morphological features have been used to reflect biomechanical behavioral patterns among archaeological populations. Of most recent ones is the anterior femoral curvature (AFC). It has been proposed as a valid indicator ...
Investigation of genes involved in somatic embryogenesis and plant-Agrobacterium interactions through transcriptional profiling
(University of Missouri--Columbia, 2021)
Plant genetic engineering relies on the ability to transmit and express cloned DNA sequences in plant cells (transformation) as well as the capacity for the cells carrying this DNA to undergo division and differentiation ...
Development of tissue based biomaterials for articular cartilage injuries
(University of Missouri--Columbia, 2020)
oxygen species production from interleukin-1beta stimulated human chondrocyte cells with addition of anti-inflammatory agent, curcumin. Finally, use of the developed liquid collagen as a potential bioink for 3D printing was investigated....
Lifestyle treatment in the regression of NASH: insulin resistance, lipid synthesis, and methodological innovation
(University of Missouri--Columbia, 2022)
This dissertation is focused on factors that increase risk for nonalcoholic fatty liver disease (NALFD) and the more advanced form nonalcoholic steatohepatitis (NASH). These factors include postprandial lipid handling ...
Multivariate analyses of polygenic risk for impulsivity and alcohol use: a study of longitudinal trajectories of binge drinking in emerging adulthood
(University of Missouri--Columbia, 2022)
This dissertation aimed to extend previous genetic and neurobiological studies of the shared etiology of impulsive personality traits (IPTs), alcohol consumption and alcohol use disorder (AUD). The overarching goals were ...
Sleep, exercise, and insulin sensitivity
(University of Missouri--Columbia, 2020)
Accumulating evidence supports short sleep duration as a novel risk factor for obesity and diabetes, but little work has been done outside of healthy men or with consideration to changes in physical activity. Thirteen ...
The antioxidative effects of exercise training-and diet-induced weight loss
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Obesity and insulin resistance (IR) increase the risk for coronary heart disease (CHD); however, much of this risk is not attributable to traditional risk factors. Elevated...
Bone regenerative engineering via controlled release of simple signaling molecules
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] More than 1.7 billion people worldwide are suffering from bone defects that are due to trauma or medical conditions such as degenerative diseases. Bone can repair and remodel...
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal protein involved...
Copper (I) coordination networks synthesized with solid-solid reactions
(University of Missouri--Columbia, 2008)
The use of solid-solid reactions in the development of one-, two-, and three dimensional Cu(I) coordination networks are discussed. The solid-solid reactions were monitored by a variety of instrumental techniques to achieve ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the applicability for each drug...
Developing, implementing, and assessing coupled-tank experiments in an undergraduate chemical engineering curriculum
(University of Missouri--Columbia, 2009)
Five experimental modules that fit into the Undergraduate Chemical Engineering Curriculum were developed using the existing Coupled-Tank Apparatus. Students of different educational levels get an opportunity to develop ...
Establishing the posh scaffold as a novel therapeutic target for treatment of B cell leukemia
(University of Missouri--Columbia, 2020)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI-COLUMBIA AT REQUEST OF AUTHOR.] More than 60,000 new cases of leukemia will be diagnosed in the U.S. this year. B cells comprise 10 [percent] of acute lymphoblastic leukemias (B-ALL) and almost all...
An ecological systems approach to reduce children's encounters with obscenity on the internet
(University of Missouri--Columbia, 2007)
Ecological Systems Model to solve the problem of children's encounters with online obscenity. The ecological systems perspective is a framework for recommendations and solutions. When each environmental system from the model collaborate in effort toward a...
The social nature of an online community of practice for learning to teach
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Taking advantage of Internet technology, an online community of practice, NETwork, was established to support a group of elementary science pre-service and in-service teachers...
Ion-selective electrodes for simultaneous real-time analysis for soil macronutrients
(University of Missouri--Columbia, 2006)
Automated sensing of soil macronutrients (i.e., N, P, and K) would allow more efficient mapping of soil nutrient variability for variable-rate nutrient management. This study reports on the development of a sensor array ...
Patient adherence to orthopaedic treatment plans : toward patient-centered definitions, measurement, and management
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Patient adherence to prescribed management protocols is associated with improved function, higher patient satisfaction, and lower complication rates following orthopaedic treatments. While adherence ...
Iron homeostasis is hierarchically regulated by multiple inputs : evidence for the role of reactive oxygen species and iron-zinc cross talk
(University of Missouri--Columbia, 2018)
to capture high quality images for automated time course analysis which we aim to distribute throughout the plant science community. Finally, I have performed the two complementary experiments to first identify Fe dependent changes in gene translation...
The culture wars & political polarization in perspective : why polarization and its perturbations are a persistant [i.e., persistent] puzzle in political science
(University of Missouri--Columbia, 2009)
Political polarization in the American electorate has received a great deal of attention in recent years with most of the research focusing on social issues and their impact on electoral outcomes. However, scant attention ...