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Prospective radiolabled bombesin conjugates for prostate cancer imaging and therapeutic agents
(University of Missouri--Columbia, 2009)
An active area of prostate cancer research is in the synthesis of radiolabeled peptides for in vivo tumor imaging or therapy. This method is possible since specific receptors are expressed in high concentration on certain ...
Development of radiolabeled metal chalcogenide nanoparticles for targeted adiotherapy against an infection
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Targeted radiotherapy has been demonstrated to be therapeutic against infections with doses comparable to what a patient would receive for cancer ...
Core-based hyperbranched polyethyleneimine coating in capillary electrophoresis
(University of Missouri--Columbia, 2009)
In capillary electrophoresis (CE), chemical and dynamic modification of a fused silica surface can be used to control the electroosmotic flow (EOF), to minimize the interaction of analytes with the capillary surface and ...
Coulomb explosions dynamics
(University of Missouri--Columbia, 2022)
Chemical reaction dynamics studies emerged with the advent of quantum mechanical theories in 1920s which have the capability of predicting the atomic motions by calculating potential energy surfaces. Experimental studies ...
Ab-initio and thermodynamic study of 123I-MIBG and 76Br-MBBG : choosing an effective tracer and theoretical study of the binding mechanism of 1-allyl 2-Thiourea as a functional monomer of Methyl Nitrate template
(University of Missouri--Columbia, 2023)
The study of mechanisms of reactions, how molecules bind, reaction energetics, and thermochemistry of chemical reactions is possible computationally. This is because computational methods are well able to help understand ...
Experimental and theoretical studies of CO2 capture from air and of crystalline, ferroelectric, non-linear optical materials
(University of Missouri--Columbia, 2022)
The combination of experimental and computational chemistry gives us a chance to explore organic materials with more breadth and depth. In this dissertation, we studied different organic materials with both experimental ...
Investigation of CO2 capture systems, Lewis acid-base pairs, and oscillating reactions with electronic structure theory and kinetics-based approaches
(University of Missouri--Columbia, 2020)
Equilibrium is a key theme in chemistry education. Starting in high school and continuing in freshman general chemistry courses, STEM students have to learn the foundations of equilibria. What is the key concept of an ...
Diels-alder reactions of a cyclopentadienone derivative
(University of Missouri--Columbia, 2007)
An ester derivative of cyclopentadienone, a very reactive species, was generated from methyl-2-bromo-3-oxocyclopent-1-enecarboxylate (96) which dimerized instantaneously and decarbonylated to generate an indanone (97). ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Studies on radiometal chelator-bombesin peptide-based radiopharmaceuticals for tumor GRP-receptor subtype mediated radioimaging
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bombesin-like peptides bind to gastrin-releasing peptide receptor subtype 2 (BB2) with significantly high binding affinity and specificity. In an ...
Stereoselective synthesis of seven-membered rings using intramolecular (4+3) cycloaddition reactions
(University of Missouri--Columbia, 2020)
Heterocyclic molecules containing seven-membered rings have importance in organic synthesis owing to their presence in some natural products and biologically active molecules. Furthermore, these scaffolds act as important ...
Synthesis and spectroelectrochemical study of novel polyhedral borane derivatives
(University of Missouri--Columbia, 2021)
The substitution chemistry of dodecahydro-closo-dodecaborate (2-) and decahydro-closodecaborate (2-) as well as the spectroelectrochemical properties of the resulted compounds which we refer to herein as "polyaryl boranes" ...
Copper (I) coordination networks synthesized with solid-solid reactions
(University of Missouri--Columbia, 2008)
The use of solid-solid reactions in the development of one-, two-, and three dimensional Cu(I) coordination networks are discussed. The solid-solid reactions were monitored by a variety of instrumental techniques to achieve ...
Self-assembly of functional metal-seamed pyrogallol[4]arene nanocapsules
(University of Missouri--Columbia, 2022)
C-alkylpyrogallol[4]arenes (PgCns, where n is the represents pendant alkyl chain lengths), bowl-shaped macrocycles, upon deprotonation, can self-assemble with metal ions into dimeric (M8L2) and hexameric (M24L6) metal-organic ...
Probing supramolecular assemblies via fluorescent reporter molecules
(University of Missouri--Columbia, 2007)
Supramolecular, self-assembled nanocapsules have shown the capability to encapsulate organic guests. Since most of the work was done previously in the solid state, the novelty of this research was its focus on probing ...
Oxidation & 1, 5-hydride shift of sulfoximine derivatives
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidation of N-alkyl and N-aryl sulfoximines and 1,5-hydride shift of S-alkenyl sulfoximines have been studied. Oxidation of N-alkyl sulfoximines using ...
An investigation of the drying properties of the lead, manganese, and cobalt soaps of tung oil
(University of Missouri--Columbia, 1914)
Lead, manganese, and cobalt linoleates are well known "driers" of linseed oil, and the drying properties of oils boiled with litharge and manganese dioxide are thought due, at least in part, to the formation of linoleates ...
Investigating the bifunctional chelate approach for radiopharmaceutical development
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Radiopharmaceuticals are drugs that contain a radioactive atom for the purpose of imaging or therapy of disease. The type of emission determines the ...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Fluorescence sensing plays an important role in a wide variety of fields such as medical science, chemical biology, food industry and so on. Several new fluorescent probes were developed to target ...
Development of selective fluorescence neurosensor for neurotransmitter monitoring in live cells
(University of Missouri--Columbia, 2022)
In the central nervous system, neurotransmitters are responsible for transferring signals from pre-synaptic vesicles to post-synaptic receptors. The most abundant amino acid in brain, glutamate, is a primary excitatory ...