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dc.contributor.advisorSegal, Steven S.eng
dc.contributor.authorMoore, Alex W.eng
dc.date.issued2010eng
dc.date.submitted2010 Summereng
dc.descriptionThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file.eng
dc.descriptionTitle from PDF of title page (University of Missouri--Columbia, viewed on October 31, 2011).eng
dc.descriptionIncludes bibliographical references.eng
dc.descriptionVita.eng
dc.descriptionThesis advisor: Steven S. Segal.eng
dc.descriptionPh. D. University of Missouri-Columbia 2010.eng
dc.descriptionDissertations, Academic -- University of Missouri--Columbia -- Veterinary biomedical sciences.eng
dc.description.abstractSympathetic nerve activity (SNA) induces arteriolar vasoconstriction via [alpha]-adrenoreceptor ([alpha]AR) activation. Whether [alpha]AR activation affects the spread of rapid onset vasodilation (ROV) in contracting muscle is unknown. Differential [alpha]AR distribution in vascular smooth muscle has been proposed to mediate functional sympatholysis, however the [alpha]AR subtype distribution in locomotor muscle is undefined. This dissertation determined: 1) the effects of constitutive [alpha]AR activation on the spread of ROV within contracting muscle, 2) the functional [alpha]AR distribution in locomotor muscle of the mouse, and 3) the influence of [alpha]AR on ROV during aging. In arterioles of the gluteus maximus muscle (GM), I tested the hypotheses that: 1) adrenoreceptor subtype distribution is heterogeneous and 2) adrenoreceptor activation modulates the spread of ROV. The left GM of young (3-month) anesthetized C57BL/6 mice were studied using intravital microscopy. Distinct anastomotic, 1A, 2A, and 3A arterioles were studied at rest and following single muscle contraction in the presence or absence of topical [alpha]AR agonists and antagonists. Functional [alpha]AR distribution differed between proximal and distal arterioles. Constitutive [alpha]AR activation inhibited the spread of ROV between regions of the GM. It also reduced the amount of ROV seen in old (~20-month) versus young male mice. I conclude that functional [alpha]AR are heterogeneously distributed in arteriolar networks and serve to modulate regional vasodilation.eng
dc.format.extentxii, 131 pageseng
dc.identifier.oclc759178702eng
dc.identifier.urihttps://hdl.handle.net/10355/12012
dc.identifier.urihttps://doi.org/10.32469/10355/12012eng
dc.languageEnglisheng
dc.publisher[University of Missouri--Columbia]eng
dc.relation.ispartofcollectionUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.relation.ispartofcommunityUniversity of Missouri-Columbia. Graduate School. Theses and Dissertations. Dissertations. 2010 Dissertationseng
dc.subject.lcshAlpha adrenoreceptorseng
dc.subject.lcshBlood vessles -- Dilationeng
dc.subject.lcshMuscle contraction -- Regulationeng
dc.subject.lcshAgingeng
dc.subject.lcshMice as laboratory animalseng
dc.subject.meshReceptors, Adrenergic, alpha-1 -- metabolismeng
dc.subject.meshReceptors, Adrenergic, alpha-2 -- metabolismeng
dc.subject.meshVasodilation -- physiologyeng
dc.subject.meshMuscle Contraction -- physiologyeng
dc.subject.meshAging -- physiologyeng
dc.subject.meshMice, Inbred C57BLeng
dc.titleEffects of adrenoreceptor activation and aging on skeletal muscle arterioles at rest and during rapid onset vasodilationeng
dc.typeThesiseng
thesis.degree.disciplineVeterinary biomedical sciences (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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