RSS 1.0Division of Pharmacology & Toxicology (UMKC)
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A Method for Identification of Pancreatic Cancer through Methylation Signatures in Cell-Free DNA
(2022)Pancreatic cancer has high mortality rates in comparison to other cancers due to limited treatment options and challenges in detecting the disease. Early diagnosis is difficult; successful outcomes are directly tied to ... -
Amphetamine-Induced Toxicity in Astrocytes and its Implications in the Pathogenesis of Psychiatric Disorders
(2022)Amphetamine-type stimulants (ATS), such as amphetamine (AMPH) and methamphetamine (METH), cause long-term toxic effects on the dopaminergic neurons in the brain leading to the development of several psychiatric disorders. ... -
Establishing Metronidazole as a Novel Biomarker of CYP2A6 Activity
(University of Missouri -- Kansas City, 2018)CYP2A6 is a polymorphically expressed enzyme with variation associated with smoking behavior, cessation success, lung cancer risk, and differential drug exposure to numerous medications including anti-infectious and ... -
Role of Redox-Active Trace Metal (RATM) Oxidants in the Regulation of Toll-Like Receptor 4 (TLR4) Signaling-Mediated Inflammatory Phenotype in Synovial Fibroblasts
(University of Missouri -- Kansas City, 2018)While the involvement of oxidant stress in rheumatoid arthritis (RA) has been suspected, the role of redox-active trace metals (RATM) as exogenous pro-oxidants in the pathogenesis of RA has not yet been investigated. ... -
Estrogen Regulation of the Wnt/β-catenin Pathway in Osteocytes in Response to Mechanical Loading
Osteoporosis is a major health concern, especially for women who are peri- and post-menopausal. During this time, estrogen levels dramatically decline followed by a subsequent loss of bone density, which increases risk of ... -
Preparation of Pentablock Nanomicellar Formulations for Prostate Cancer Drug Delivery Systems
(University of Missouri -- Kansas City, 2018)This study is divided into three specific aims. Specific aim #1 focused on synthesis of pentablock co-polymer using monomers of L-lactide, ε-caprolactone and ethylene-glycol with varied molecular weights, (ii) ... -
Effect of TIMBD on Neurotoxicity Associated with HIV-1 Gp120 and Tat
(University of Missouri -- Kansas City, 2018)Human Immunodeficiency Virus (HIV)-associated neurocognitive disorder (HAND) is one of the undermining disorders that affects majority of HIV infected patients. Patients with HAND suffer from both cognitive and motor ... -
The effects of HIV-1 viral protein r (vpr) and anti-retroviral drugs in the brain: Implications in HIV-1 associated neurocognitive disorders
(University of Missouri--Kansas City, 2016)The morbidity and mortality of HIV-1 infected individuals has declined significantly by the introduction of highly active antiretroviral therapy (HAART). Nevertheless, different forms of HIV-1 associated neurocognitive ... -
Role of Toll-Like Receptor 4 in Oxidant-induced Inflammatory Phenotypes in Macrophages
(University of Missouri--Kansas City, 2017)A common mechanism by which redox stress may activate inflammatory responses to potentially initiate, propagate and maintain many diseases states has not been characterized. Accumulating evidence suggests that pattern ... -
The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
(University of Missouri--Kansas City, 2017)Human immunodeficiency virus-1 (HIV-1) enters the brain through blood brain barrier (BBB) early after the infection and leads to various neurological complications including HIV associated dementia (HAD). Introduction ... -
The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
(University of Missouri--Kansas City, 2016)The life expectancy of individuals infected with HIV-1 has significantly improved since the introduction of highly active anti-retroviral therapy (HAART). However, this has led to an increase in the prevalence of HIV-associated ... -
Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70% compared to 15-20% in the general population, which further increases the risk of smoking-related health problems in this group. ... -
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ... -
Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
(2013-11-13)Abstract Background Neurocognitive impairments remain prevalent in HIV-1 infected individuals despite current antiretroviral therapies. It is increasingly becoming evident that astrocytes ... -
Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer
(2013-05-22)Abstract Background Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, ... -
Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643
(2004-05-24)Abstract Background The metabolic inhibitor rotenone inhibits hepatocellular proliferation and the incidence of liver cancer ... -
Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53
(2003-01-03)Abstract Background Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor ... -
Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated viaenhanced serum corticosterone levels: Molecular Fitting and Receptor Activation Studies
(2003-02-14)Abstract Background Recent studies suggest that rotenone alters cell signal transduction pathways in a manner similar to glucocorticoids. ... -
Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha:a role for kupffer cells?
(2006-11-27)Abstract Background It has been proposed that PPARα agonists stimulate Kupffer cells in rodents which in turn, release ... -
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
(2010-10-05)Abstract Background The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses to the environment include elevating defense systems, such as the ...