RSS 1.0Division of Pharmacology & Toxicology (UMKC)
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Cytochrome P450 enzymes and oxidative stress in tobacco/nicotine mediated HIV pathogenesis
(2016)In the US, the prevalence of cigarette smoking in the HIV-infected population is 50-70% compared to 15-20% in the general population, which further increases the risk of smoking-related health problems in this group. ... -
The Cellular and Molecular Mechanisms of Prostaglandin E₂ in Myogenesis
(2013)Prostaglandin E₂ (PGE₂), the most abundant prostaglandin (PG) in our body, has multiple biological functions related to physiological activities and the development of diseases. Emerging evidence has shown that PGE2 plays ... -
Human immunodeficiency virus type 1 viral protein R (Vpr) induces CCL5 expression in astrocytes via PI3K and MAPK signaling pathways
(2013-11-13)Abstract Background Neurocognitive impairments remain prevalent in HIV-1 infected individuals despite current antiretroviral therapies. It is increasingly becoming evident that astrocytes play a ... -
Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer
(2013-05-22)Abstract Background Estrogen metabolism-mediated oxidative stress is suggested to play an important role in estrogen-induced breast carcinogenesis. We have earlier demonstrated that antioxidants, ... -
Correlation between thyroid hormone status and hepatic hyperplasia and hypertrophy caused by the peroxisome proliferator-activated receptor alpha agonist Wy-14,643
(2004-05-24)Abstract Background The metabolic inhibitor rotenone inhibits hepatocellular proliferation and the incidence of liver cancer ... -
Hepatocarcinogenic potential of the glucocorticoid antagonist RU486 in B6C3F1 mice: effect on apoptosis, expression of oncogenes and the tumor suppressor gene p53
(2003-01-03)Abstract Background Glucocorticoids inhibit hepatocellular proliferation and modulate the expression of oncogenes and tumor ... -
Glucocorticoid-like effects of antihepatocarcinogen Rotenone are mediated viaenhanced serum corticosterone levels: Molecular Fitting and Receptor Activation Studies
(2003-02-14)Abstract Background Recent studies suggest that rotenone alters cell signal transduction pathways in a manner similar to glucocorticoids. ... -
Hepatocellular proliferation in response to agonists of peroxisome proliferator-activated receptor alpha:a role for kupffer cells?
(2006-11-27)Abstract Background It has been proposed that PPARα agonists stimulate Kupffer cells in rodents which in turn, release ... -
Neuroprotective effect of peroxiredoxin 6 against hypoxia-induced retinal ganglion cell damage
(2010-10-05)Abstract Background The ability to respond to changes in the extra-intracellular environment is prerequisite for cell survival. Cellular responses to the environment include elevating defense systems, such as the ... -
Tocotrienols inhibit lipopolysaccharide-induced pro-inflammatory cytokines in macrophages of female mice.
(2010-12-16)Abstract Background Inflammation has been implicated in cardiovascular disease, and the important role of proteasomes in the development of inflammation and other macrophage functions has been demonstrated. ... -
HIV-1 gp120-mediated increases in IL-8 production in astrocytes are mediated through the NF-kappaB pathway and can be silenced by gp120-specific siRNA
(2010-12-29)Abstract Background The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine ... -
delta-Tocotrienol and quercetin reduce serum levels of nitric oxide and lipid parameters in female chickens
(2011-02-28)Abstract Background Chronic, low-grade inflammation provides a link between normal ageing and the pathogenesis of age-related diseases. A series of in vitro tests confirmed the strong anti-inflammatory activities ... -
Tocotrienols-induced inhibition of platelet thrombus formation and platelet aggregation in stenosed canine coronary arteries.
(2011-04-14)Abstract Background Dietary supplementation with tocotrienols has been shown to decrease the risk of coronary artery disease. Tocotrienols are plant-derived forms of vitamin E, which have potent anti-inflammatory, ... -
Inhibition of nitric oxide and inflammatory cytokines in LPS-stimulated murine macrophages by resveratrol, a potent proteasome inhibitor
(2012-06-14)Abstract Background: Altered immune function during ageing results in increased production of nitric oxide (NO) and other inflammatory mediators. Recently, we have reported that NO production was inhibited ... -
Involvement of metabotropic glutamate receptor 5, AKT/PI3K Signaling and NF-kappaB pathway in methamphetamine-mediated increase in IL-6 and IL-8 expression in astrocytes
(2012-03-15)Abstract Methamphetamine (MA) is one of the commonly used illicit drugs and the central nervous system toxicity of MA is well documented. The mechanisms contributing to this toxicity have not been fully elucidated. In this ... -
Inhibition of nitric oxide in LPS-stimulated macrophages of young and senescent mice by delta-tocotrienol and quercetin.
(2011-12-20)Abstract Background Changes in immune function believed to contribute to a variety of age-related diseases have been associated with increased production of nitric oxide (NO). We have recently reported that ... -
Suppression of nitric oxide induction and pro-inflammatory cytokines by novel proteasome inhibitors in various experimental models
(2011-10-12)Abstract Background Inflammation has been implicated in a variety of diseases associated with ageing, including cancer, cardiovascular, and neurologic diseases. We have recently established that the proteasome ...