Browsing Theses and Dissertations (MU) by Thesis Department "Chemistry (MU)"
Now showing items 21-40 of 322
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Arsenic for potential diagnostic imaging and radiotherapy
(University of Missouri--Columbia, 2015)Targeted agents hold promise for non-invasive in vivo imaging, therapy, and monitoring of diseases. Foundational work focused on imaging and therapy of cancer has centered primarily on the use of 18F, 90Y, 99mTc, and 131I ... -
Arsenic-72, 77 as a matched pair radiopharmaceutical for imaging and radiotherapy
(University of Missouri--Columbia, 2018)Radiopharmaceuticals deliver radionuclides to specific target sites via the bifunctional chelate approach, where the radionuclides are chelated with a ligand and linked to a targeting biomolecule. They can be categorized ... -
Atomic-scale studies of chemical and transport processes relevant to propellant combustion
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Density functional theory (DFT) and correlated molecular orbital electronic structure calculations were used to study the Al + CO2 [subscript arrow] ... -
Aza-analogues of distyrylbenzene (DSB) synthesis, structures, and properties of 1,4-phenylenediamine bisimines (PDABI)
(University of Missouri--Columbia, 2006)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The drive for electo-optically active materials was officially initiated in 1966 with the publishing, by NASA, of a 137 page report. The "Electro-optic ... -
Biologically relevant chemistry of sulfur heterocycles : from redox regulation of PTP1B to the biological activity of s-deoxy leinamycin
(University of Missouri--Columbia, 2008)Protein tyrosine phosphatase 1B (PTP1B) is an important member of protein tyrosine phosphatase (PTPs) family that shares a conserved catalytic cysteine thiol residue. PTP1B acts as a negative regulator of insulin mediated ... -
Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ... -
Bioreductive metabolism of small molecule nitroaromatics and N-oxides in hypoxia
(University of Missouri--Columbia, 2012)Hypoxia in tumors causes adverse effects to therapy and negatively impacts on patient prognosis. Identification and quantification of hypoxia is considered to have a strong impact on treatments in tumor therapy. Fluorescent-based ... -
Bioreductive metabolism of small molecule nitroaromatics and N-oxides in hypoxia
(University of Missouri--Columbia, 2012)Hypoxia in tumors causes adverse effects to therapy and negatively impacts on patient prognosis. Identification and quantification of hypoxia is considered to have a strong impact on treatments in tumor therapy. Fluorescent-based ... -
Boron neutron capture therapy at the University of Missouri using select purpose-built compounds
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Boron Neutron Capture Therapy (BNCT) of multiple cancer lines is demonstrated in mice using unilamellar liposomes as a boron delivery vehicle. BNCT is ... -
Boron quantitative analysis and imaging analysis in plants
(University of Missouri--Columbia, 2017)Boron is a very important nutrient element in plants, and thus it plays a key role in the world's food supply. Both boron deficiency and boron toxicity will cause plants to decrease their crop yield or even cause plants ... -
Broadband rotational spectroscopy in Laval flows: applications in astrochemistry and dynamics
(University of Missouri--Columbia, 2022)This dissertation presents the successful implementation of a Chirped pulse Uniform Flow (CPUF) apparatus capable of conducting experiments at low temperatures to examine photodissociation/reaction dynamics and kinetics ... -
Bromine photoelimination from organoplatinum(IV) complexes
(University of Missouri--Columbia, 2014)With burgeoning population growth and widespread economic development world energy consumption is constantly on the rise. Currently most of our energy requirements are met through fossil fuels which are non-renewable. The ... -
Characterization of acyclic rhodium tetrathioether ligans systems for 105Rh(III)
(University of Missouri--Columbia, 2015)Rhodium-105 is a 36 hr half-life beta emitter potentially useful for radiotherapy. Previously, the reaction of 105 Rh-cholride with a linear tetrathioether ligand resulted in several species. Evaluation of this reaction ... -
Characterizing and understanding self-assembling, nanocapsule host-guest systems
(University of Missouri--Columbia, 2010)Supramolecular, self-assembled nanocapsules have been shown to be capable of entrapping fluorescent guests. Previous solid- and solution-state research, focusing on hydrogen-bonded C-alkylpyrogallol[4]arenes (PgC6)nanocapsules, ... -
Chemical and biochemical properties of abasic site adducts and 6-thioguanine DNA cross-links in DNA
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] DNA is a macromolecular complex, composed of the nucleotides adenine, thymine, guanine and cytosine interconnected by a phosphate backbone, that contains ... -
Chemical and strutural properties of DNA-abasic site cross-links
(University of Missouri--Columbia, 2014)Here, we report on the formation of DNA interstrand cross-links. These cross-links form from abasic sites, an endogenous type of DNA damage. We have utilized gel electrophoresis, NMR, mass spectrometry and liquid chromatography ... -
Chemical mechanisms of DNA damaging natural products
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Natural products provide both novel molecular structures and new mechanisms that have significant therapeutical implications. The work described here ... -
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ... -
Chemistry dissertation (not yet available)
(University of Missouri--Columbia, 2015) -
Chlorine and singlet oxygen photoelimination from organoplatinum(IV) complexes
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Solar energy is the most promising carbon neutral energy source for the future. Splitting of simple molecules like HX (X = Cl, Br) has become an ...