Browsing Dissertations (MU) by Thesis Department "Microbiology and Immunology (MU)"
Now showing items 1-6 of 6
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Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] The main aim of this dissertation was to display novel immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory ... -
Interplay of Bacillus anthracis spore proteins in the assembly process of the exosporium
(University of Missouri--Columbia, 2023)Spores are the infectious form of the zoonotic pathogen, Bacillus anthracis. The outermost layer of these spores is the exosporium. It consists of a basal layer (major structural proteins are ExsY, CotY, BxpB, and ExsFB) ... -
Mechanisms of inflammation resolution in a murine model of Lyme arthritis
(University of Missouri--Columbia, 2023)In some patients, Lyme arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi ... -
The multiple roles of FzlA during cell division and stress responses in Agrobacterium tumefaciens
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Disruption of the complex and dynamic process of bacterial cell division results in cellular changes to protect the cells from lysis. In the plant pathogen Agrobacterium tumefaciens, absence of ... -
Persistence of plague : determining which environmental factors contribute to maintenance of Yersinia pestis within sylvatic cycles
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Plague is a prioritized zoonotic disease caused by Yersinia pestis, a gram-negative bacterium. Sylvatic cycles of rodent host and flea vectors have established endemic foci responsible for the ... -
A role played by sex in innate immune memory and disease severity
(University of Missouri--Columbia, 2023)While immunological memory has traditionally been understood to be solely within the purview of adaptive immunity, recent evidence has shown that a type of "memory" exists in innate immune cells, as a prior insult can lead ...