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Optimal designs for response functions with a downturn
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In many toxicological assays, interactions between primary and secondary effects may cause a downturn in mean responses at high doses. In this situation, ...
Adaptive optimal designs for dose-finding studies and an adaptive multivariate CUSUM control chart
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] There are many areas where optimal designs are applied to, for example, the development of a new drug, where a conventional dose- finding study involves ...