Characterization of acyclic rhodium tetrathioether ligans systems for 105Rh(III)

Abstract

Rhodium-105 is a 36 hr half-life beta emitter potentially useful for radiotherapy. Previously, the reaction of 105 Rh-cholride with a linear tetrathioether ligand resulted in several species. Evaluation of this reaction at the macroscopic level showed that multiple isomers formed depending on the reaction conditions. Radiotracer syntheses for use in potential radiopharmaceuticals require formation of a single species. Various reaction conditions were examinded at the macroscopic level to drive the reaction to a single species, evaluating the effects of reducting agent, solvent, temperature, salt concentration, HCl concentration, pH, and reaction time. Product distributions were evaluatted by LC-MS, NMR, and x-ray crystallography.