Browsing Chemistry electronic theses and dissertations (MU) by Identifier "https://hdl.handle.net/10355/9876"
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Metabolically activated heterocyclic N-oxide compounds for killing and visualizing hypoxic cancer cells
(University of Missouri--Columbia, 2009)Tirapazamine (TPZ) is currently undergoing a variety of phase I, II, and III clinical trials for the treatment of various human cancers. TPZ derives its medicinal activity by inducing DNA damage in poorly oxygenated tumor ...