Browsing Chemistry electronic theses and dissertations (MU) by Thesis Semester "2014 Summer"
Now showing items 1-8 of 8
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Bromine photoelimination from organoplatinum(IV) complexes
(University of Missouri--Columbia, 2014)With burgeoning population growth and widespread economic development world energy consumption is constantly on the rise. Currently most of our energy requirements are met through fossil fuels which are non-renewable. The ... -
Covalent adduct formation between the antihypertensive drug hydralazine and abasic sites in double and single-stranded DNA
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Hydralazine is an antihypertensive agent that displays both mutagenic and epigenetic properties. Here, we provide evidence that medicinally-relevant ... -
The development of the first generation of exo-affinity labeling agents, inactivators of protein tyrosine phosphatase 1B
(University of Missouri--Columbia, 2014)Type II Diabetes (T2DB) is one of the worldwide problems characterized by ineffective insulin signal transduction as a result of insulin resistance and impaired glucose homeostasis. Protein Tyrosine Phosphatase 1B (PTP1B), ... -
Hypoxia selective DNA alkylating analogs of tirapazamine and Ap-derived DNA interstrand cross-links
(University of Missouri--Columbia, 2014)Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide, TPZ) is a heterocyclic di-N-oxide that can be selectively reduced enzymatically in oxygen-poor (hypoxic) cells commonly associated with solid tumors. This reduction ... -
Incorporating spectroscopy and measurement technology into the high school chemistry laboratory
(University of Missouri--Columbia, 2014)Science and technology are becoming increasingly important in maintaining a healthy economy at home and a competitive edge on the world stage, though that is just one facet affected by inadequate science education in the ... -
Spectroscopic Studies of Proteins and Their Interactions with Lipids and Small Molecules
(University of Missouri--Columbia, 2014) -
Studies toward the carbanion-accelerated 6[Pi] electrocyclization : polyfunctional boronates
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The 6π electrocyclization remains an important class of pericyclic reactions which provides access to substituted six-membered rings from uncyclized ... -
Understanding substrate binding and movement in proline catabolic enzymes
(University of Missouri--Columbia, 2014)Proline catabolism is the breakdown of proline to glutamate. This is catalyzed by two enzymes that can be either distinct, monofunctional enzymes or fused into one bifunctional enzyme. When the two enzymes are fused together ...