Browsing Chemistry electronic theses and dissertations (MU) by Title "Hypoxia selective DNA alkylating analogs of tirapazamine and Ap-derived DNA interstrand cross-links"
Now showing items 1-1 of 1
-
Hypoxia selective DNA alkylating analogs of tirapazamine and Ap-derived DNA interstrand cross-links
(University of Missouri--Columbia, 2014)Tirapazamine (3-amino-1,2,4-benzotriazine 1,4-dioxide, TPZ) is a heterocyclic di-N-oxide that can be selectively reduced enzymatically in oxygen-poor (hypoxic) cells commonly associated with solid tumors. This reduction ...