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Viral envelope proteins and the HIV-1 accessory gene Vpu mediate selectivity of viral and host proteins in retroviral assembly
(University of Missouri--Columbia, 2012)
Retroviruses are enveloped RNA viruses that assembly primarily at the plasma membrane of the host cell. During budding from the membrane, they acquire their own glycoproteins as well as a lipid bilayer derived from the ...
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ...
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ...
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T ...
Mechanistic inhibition studies of SARS-CoV replication and entry
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus, (SARS-CoV) and ...
Yersinia pestis YopK contributes to immune evasion and cell death to promote plague
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] YopK is a 21-kilodalton protein that is secreted and translocated by the type three secretion system of Yersinia pestis, the causative agent of pneumonic, ...
Characterization of the non-structural proteins of adeno-associated virus (AAV) and minute virus of canine (MVC)
(University of Missouri--Columbia, 2012)
Parvoviruses are among the smallest of the animal DNA viruses. Due to their compact genome, these viruses display immense heterogeneity both in the mechanisms involved in gene expression and the functions of the encoded ...
Factors contributing to humoral immunity against pneumonic plague
(University of Missouri--Columbia, 2012)
Yersinia pestis is the etiologic agent of plague and is responsible for more human deaths throughout history than any other bacterial pathogen. During infection bacteria inject effector proteins into target host cells using ...
Characterization of the role of the DNA damage response pathway in parvoviral replication
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] We report that low multiplicity infection with the autonomous parvovirus minute virus of mice (MVM) results in the activation of a DNA damage response ...
Identification and characterization of Bacillus anthracis spore-associated proteins
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Bacillus anthracis is a Gram-positive, rod-shaped, spore-forming bacterium and the etiological agent of anthrax. Spore formation is essential for ...
Posttranscriptional gene regulation by the RNA binding protein HuR in two disease models : allergic asthma and breast cancer
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The RNA binding protein HuR binds to the AU-rich (ARE) regions of labile mRNAs, such as proto-oncogenes, stabilizing their mRNA and facilitating their ...
Gene replacement restores the contractile and passive properties of skeletal muscle in murine models of Duchenne muscular dystrophy
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Duchenne muscular dystrophy (DMD) is a lethal disease caused by the loss of the dystrophin protein. Loss of mobility is a key clinical presentation in ...
Mechanisms of inhibition and resistance to antiviral drugs targeting human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Although human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) are very different viruses, the replication of their genome involves ...
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ...