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Novel mouse models for spinal muscular atrophy with respiratory distress type I : characterizing disease relevant models and evaluating therapeutic potential
(University of Missouri--Columbia, 2021)
Spinal muscular atrophy with respiratory distress type I (SMARD1) is a rare neurodegenerative disease caused by loss-of-function mutations in the immunoglobulin µ-DNA binding protein 2 (IGHMBP2). SMARD1 is defined by severe ...
Inhibition and comprehensive analysis of hiv-1 vpu, examination of retroviral trafficking, and characterization of sars-cov-2 genetic material in wastewater
(University of Missouri--Columbia, 2021)
Both HIV-1 and SARS-CoV-2 have been responsible for millions of infectionrelated deaths. Despite advances in treatment for both viruses, neither has a cure, and those living with the disease can unknowingly spread the ...
The influence of type II cytokines in central tolerance
(University of Missouri--Columbia, 2021)
While the genetic elements of many autoimmune conditions have been established, many environmental factors remain a mystery. Exposure to certain infections has been implicated as a possible explanation for the significantly ...
Influenza virus strategies to regulate S1P-metabolizing enzymes and evade host innate immunity for robust viral replication
(University of Missouri--Columbia, 2021)
Viral infection is a complex network of interactions involving the host defending itself against the virus and the virus attempting to subdue host defenses and utilize the cellular machinery to promote its replication. ...
Refinement of an established large-animal model to understand the tick-pathogen-host interface
(University of Missouri--Columbia, 2021)
Ticks are globally distributed vectors of important pathogens of human and animal health. Since the discovery of tick resistance in 1918, the field has sought continuously for the development of effective biologic control ...