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Evaluation of calcium handling and dwarf open reading frame AAV gene therapy in Duchenne muscular dystrophy
(University of Missouri--Columbia, 2022)
Duchenne muscular dystrophy (DMD) is a progressive muscle wasting disease. Increased concentrations of cytosolic calcium in dystrophic muscle cells has been implicated in DMD pathogenesis. In healthy muscle, calcium from ...
Understanding the role of Coxiella outer membrane protein-1 in relation to the Type IVB Secretion system of Coxiella burnetii
(University of Missouri--Columbia, 2022)
Obligate intracellular bacterial pathogens, like Coxiella burnetii, the causative agent of Q Fever, rely upon the host for metabolites and carbon sources for energy and biosynthesis of nucleic acids, proteins, and energy ...
Understanding the insect immune responses to Yersinia pestis using Drosophila melanogaster
(University of Missouri--Columbia, 2022)
Yersinia pestis, the causative agent of plague, continues to be transmitted in many different continents, most often by fleas. Despite knowing for a century that Y. pestis can form a biofilm on the flea's proventriculus ...