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A role played by sex in innate immune memory and disease severity
(University of Missouri--Columbia, 2023)
While immunological memory has traditionally been understood to be solely within the purview of adaptive immunity, recent evidence has shown that a type of "memory" exists in innate immune cells, as a prior insult can lead ...
Interplay of Bacillus anthracis spore proteins in the assembly process of the exosporium
(University of Missouri--Columbia, 2023)
Spores are the infectious form of the zoonotic pathogen, Bacillus anthracis. The outermost layer of these spores is the exosporium. It consists of a basal layer (major structural proteins are ExsY, CotY, BxpB, and ExsFB) ...
Proposed characterization of POSH function in human T-cell Acute Lymphoblastic Leukemia
(University of Missouri--Columbia, 2023)
T-cell Acute Lymphoblastic Leukemia (T-ALL) is an aggressive malignancy that is characterized by leukemic T-cells that can express reduced T-cell markers (such as CD5, CD4, or CD8) reflecting their transformation from an ...
The multiple roles of FzlA during cell division and stress responses in Agrobacterium tumefaciens
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Disruption of the complex and dynamic process of bacterial cell division results in cellular changes to protect the cells from lysis. In the plant pathogen Agrobacterium tumefaciens, absence of ...
Chimeric Thrombomodulin and CD47 proteins synergistically improve the engraftment of islets by mitigating IBMIR
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] The main aim of this dissertation was to display novel immunological ligands, Thrombomodulin (TM) and CD47, on the surface of islets to promote islet engraftment by controlling thrombotic/inflammatory ...
Persistence of plague : determining which environmental factors contribute to maintenance of Yersinia pestis within sylvatic cycles
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 5/1/2024] Plague is a prioritized zoonotic disease caused by Yersinia pestis, a gram-negative bacterium. Sylvatic cycles of rodent host and flea vectors have established endemic foci responsible for the ...
Mechanisms of inflammation resolution in a murine model of Lyme arthritis
(University of Missouri--Columbia, 2023)
In some patients, Lyme arthritis persists despite antibiotic clearance of Borrelia burgdorferi, indicating an underlying defect in inflammation resolution mechanisms. In the murine model of Lyme arthritis (mLA), B. burgdorferi ...