Veterinary Pathobiology electronic theses and dissertations (MU): Recent submissions
Now showing items 21-40 of 73
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Development of a nanomaterial-tissue patch for vascular and cardiac reconstruction
(University of Missouri--Columbia, 2014) -
Defining the therapeutic window in spinal muscular atrophy :
(University of Missouri--Columbia, 2013)Spinal muscular atrophy (SMA) is caused by the loss of a single gene, survival motor neuron-1 (SMN1), which results in the rapid deterioration of motor neuron integrity and function, most often leading to infantile death. ... -
Development of model systems for the vector-host-pathogen interface of bubonic plague
(University of Missouri--Columbia, 2013)Bubonic plague infections begin in the dermis when the pathogen is introduced by a flea during a routine blood feed. Several barriers separate Yersinia pestis from its replicative niche, including phagocytic cells in the ... -
Identification of factors that promote satellite cell motility
(University of Missouri--Columbia, 2014)An important but poorly understood aspect of stem cell-mediated skeletal muscle regeneration is stem cell recruitment and motility within the damaged tissue; a failure to spread after therapeutic engraftment is also a key ... -
Posttranscriptional gene regulation of IL-17 by the RNA-binding protein HuR required for initiation of autoimmune neuroinflammation
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Posttranscriptional gene regulation is a critical mechanism of controlling the gene expression. The RNA binding-proteins (RBPs) mediate RNA splicing, ... -
The role of the innate immune system in microbially induced intestinal inflammation and neoplasia
(University of Missouri--Columbia, 2013)Inflammatory bowel disease (IBD) is one of the most common immune-mediated diseases in the United States costing the average patient tens of thousands of dollars annually, and greatly diminishing quality-of-life. While ... -
Characterizing the progression of disease associated with human meniscal pathology
(University of Missouri--Columbia, 2013)Meniscal fibrocartilaginous structures are subject to numerous stresses when performing its necessary functions to maintain intra-articular homeostasis. Pathological events causing a loss of tissue integrity will result ... -
Arsenic speciation of swine urine for possible use in human exposure assessments
(University of Missouri--Columbia, 2013)Commonly found arsenic species in human urine are AsIII (arsenite), AsV (arsenate), MMA (monomethyl arsenic acid), DMA (dimethylarsinic acid) and AB (arsenobetaine). Evidence has shown that these species vary in toxicity ... -
Ecomorphological implications of primate dietary variability: an experimental model
(University of Missouri--Columbia, 2013)The evolution and function of the mammalian skull and feeding apparatus is intimately related to the mechanical demands imposed by food items. The diets of wild species are often seasonal and thus individuals may experience ... -
Molecular genetic studies in canine inherited diseases including neonatal cerebellar ataxia, degenerative myelopathy and multiple system degeneration
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The inherited diseases of the domestic dog mimic a wide spectrum of common human disorders. By identifying the genes that harbor the mutations underlying ... -
Murine theiloviruses : characterization and pathogenesis of enteric and disseminated disease
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Rat theilovirus (RTV), a member of the Theilovirus (ThV) species and closely related to Theiler's murine encephalomyelitis virus (TMEV), is a prevalent ... -
The utility and limitations of the TRAMP model system for studying the effects of hedgehog targeted therapy in prostate cancer
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Advanced prostate cancer has a very poor prognosis and no curative therapies. Understanding of the hedgehog (Hh) signaling pathway, a potential target ... -
Development of biological hip resurfacing in dogs
(University of Missouri--Columbia, 2012)Total joint replacement remains an excellent treatment for patients with debilitating joint degeneration. However, joint replacement using non-absorbable prostheses can deteriorate and become loose over time. A superior ... -
The evaluation of a bioactive biomaterial scaffold for the tissue engineering of articular cartilage
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Bilayered tissue-engineered osteochondral (OC) grafts require the integration of two components; a superficial layer consisting of articular cartilage ... -
Kinetics of monocytotropic Ehrlichia infections, new insights from large animal models
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ehrlichia are tick-borne, obligate intracellular prokaryotic parasites found in host-derived parasitophorous vacuoles. The monocytotropic Erlichia ... -
The feasibility of interspecific rescue of endothelial/hematopoietic lineage deficiency
(University of Missouri--Columbia, 2012)Here we propose to develop a mouse model which will establish “proof of principle” for future development of large animal (e.g. pig) models which could be used as actual human solid organ and blood donors as well as in ... -
Universal blood : the life stream all four one and one for all : an enzymatic methodology creating a universal blood supply
(University of Missouri--Columbia, 2012)α-NAGA (α-N-acetylgalactosaminidase) is an exoglycosidase that cleaves a specific carbohydrate, terminal linked 1-3 α-N-acetylgalactosamine, from the A antigen. The enzymatic hydrolysis creates the H antigen. This modification ... -
Characterization of the pigmentation locus in Yersinia pestis pathogenesis of pneumonic plague
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The extreme virulence of Yersinia pestis in all three forms of plague disease is attributed to its multiple virulence factors. Y. pestis pathogenesis ... -
Targeted 177 Lu antisense radiotherapy of B-cell non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The B-cell lymphoma/leukemia-2 (bcl-2) proto-oncogene in non-Hodgkin's lymphoma (NHL) is a dominant inhibitor of apoptosis. The research goal was to ... -
The identification of a diagnostic biomarker panel for canine osteoarthritis
(University of Missouri--Columbia, 2010)A novel biomarker panel for the diagnosis of early osteoarthritis (OA) in canines has been identified. This panel consists of monocyte chemoattractant protein 1 (MCP1), interleukin-8 (IL-8), keratinocyte-derived chemoattractant ...