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Role of natural and synthetic progestins in progression of human breast cancer cells in an animal model [abstract]
(2010-03)
Post-menopausal women with an intact uterus receive combined dose of estrogen and progestin during hormone replacement therapy (HRT) to reduce clinical symptoms such as hot flashes. Progestins, which include natural and ...
Angiotensin converting enzyme modulates corneal angiogensis in vivo
(2010-02)
Purpose: We tested (i) whether a renin-angiotensin system exists within the cornea, and (ii) its role in modulating corneal neovascularization (CNV) in vivo. Methods: Rabbit corneal fibroblast and corneal epithelial cell ...
Bisphosphonate therapy, wound healing and the pathobiology of osteonecrosis of the jawbone [abstract]
(2010-02)
Bisphosphonates (BP) like Zometa (ZA) are widely used to treat complications of bony metastases in cancer patients, with 3 million patients receiving BP therapy worldwide. A serious adverse event occurs in 1-12% of patients ...
Binge ethanol drinking causes protracted insomnia [abstract]
(2010-02)
Binge drinking, loosely defined as rapid and excessive drinking, is a welldocumented behavior especially among teens. However, there are no reports on the effects of binge drinking on sleep. Since sleep is critical for ...
Bioinformatic prediction of ultraviolet light mutagenesis sensitive human genes [abstract]
(2010-02)
Living on earth, we are exposed to ultraviolet (UV) light as part of the solar radiation. UVB spectrum light exposure contributes to the development of skin cancer by interacting with pyrimidine pairs to create lesions ...
Bone marrow failure associated with CD8 T-cell expansion in a patient with trichorhinophalangeal syndrome and common variable immunodeficiency [abstract]
(2010-02)
Objective: To report a case of trichorhinophalangeal syndrome coexistent with common variable immunodeficiency (CVID)-like phenotype with a polyclonal expansion of CD8 T-cells Case: A 34-year-old white woman with multiple ...
A dance-movement therapeutic intervention to improve balance and gait in community-based frail seniors : a pilot study [abstract]
(2010-02)
Statement of the Problem: Loss of balance and diminished gait are major fall risk factors in older persons. Literature suggests that physical activity based on dance may improve balance and gait. The aim of this pilot study ...
Confounding of racial and socioeconomic risk factors in epidemiological assertions sampled from Robbins and Cotran : pathologic basis of disease [abstract]
(2010-02)
Background: Learning the risk factors for various diseases is an important part of medical education. However, when medical texts document racial risk factors for particular diseases, that information may be misleading if ...
Do patients with craniosynostosis have increased incidence of auditory neuropathy newborns? [abstract]
(2010-02)
Objective: To investigate the incidence of abnormal auditory brainstem response (ABR) with normal otoacoustic emissions, in newborn patients with craniosynostosis as compared to published standards. Design: A retrospective ...
Verbal pain scores and their association with vital signs before and after surgery [abstract]
(2010-03)
The purpose of the research project was to determine if an association existed between self-reported verbal pain scores and heart rate, blood pressure, and respiratory rate in adult patients who had elective surgery at the ...
Gaining understanding of South African traditional helers' management of lymphedema following breast cancer treatment : building a foundation for a synergistic model of best practices [abstract]
(2010-03)
As of 1999, breast cancer (BC) was the leading cause of cancer diagnosis in South African women, affecting 1 in 12 Caucasian and 1 in 18 ethnically diverse South African women. In order to improve BC survivorship, the ...
The effectiveness of bilateral versus unilateral task retraining using the saeboflex orthosis in individuals with subacute and chronic stroke [abstract]
(2010-02)
The purpose of this study is to examine the effectiveness of the SaeboFlex orthosis, comparing unilateral versus bilateral task training with the device in patients with subacute and chronic stroke. This study addresses ...
Disruption of e-cadherin junctional integrity in ovarian cancer cells is promoted by LPA-induced MMP-9 activity [abstract]
(2010-02)
Approximately 22,000 U.S. women are newly diagnosed each year with epithelial ovarian cancer (EOC), 75% of whom present with existing metastases and peritoneal ascites. A key event in EOC metastasis is disruption of cell-cell ...
Facial phenotypic differences in children with autism spectrum disorders [abstract]
(2010-03)
The brain develops in concert and in coordination with the developing facial tissues, with each influencing the development of the other. Autism spectrum disorders (ASD) result from alterations in the embryological brain, ...
Gold nanoparticles (GNP) or adeno-associated virus (AAV) mediated gene delivery in human corneal endothelial cells [abstract]
(2010-03)
Purpose: Healthy Corneal endothelium is essential for corneal clarity. Treatment of defective corneal endothelial function often requires corneal transplant. Gene therapy is an attractive approach to treat/cure corneal ...
This little piggy went running, that little piggy stayed home : a forelimb perspective of limb loading [abstract]
(2010-03)
Variation in mechanical loading is known to influence chondral modeling. However, the interaction between chondrocyte behavior, skeletal morphology, and ontogenetic variation in activity patterns are variably understood. ...
Sudden cardiac death in a young man with massive left ventricular pseudoaneurysm
(2010-03)
Introduction: Left ventricular (LV) pseudoaneurysm (PA) is a known complication of myocardial infarction and rarely, mitral valve (MV) replacement surgery or endocarditis. PAs are prone to rupture with a 50% mortality rate ...
Studying physician use and satisfaction with web-based treatment guides that incorporate patient information from the electronic medical record [abstract]
(2010-03)
Clinical decision support tools are important components of the electronic medical record. Previous studies have demonstrated that such tools can directly improve patient care outcomes and the performance of healthcare ...
Utrophin up-regulation helps maintain normal cardiac geometry in a gene therapy model for Duhenne muscular dystrophy heart disease [abstract]
(2010-03)
Duchenne muscular dystrophy (DMD) is the most common childhood muscle wasting disease. DMD sufferers rarely survive past their mid-twenties succumbing to respiratory or heart failure. Skeletal and heart muscle pathology ...
Transcription factors, 5'-TG-3'- ineracting factors (TGIF), regulates trichostatin-A mediated inhibition of corneal scarring [abstract]
(2010-03)
Purpose: Recently, we demonstrated that Trichostatin-A (TSA) inhibits transforming growth factor beta 1 (TGF 1)-induced fibrosis (haze) in rabbit cornea in vivo. However, the molecular mechanism of this process is still ...