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dc.contributor.advisorXu, Dong, 1965-eng
dc.contributor.authorZhang, Ningeng
dc.date.issued2018eng
dc.date.submitted2018 Summereng
dc.description.abstract[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Eukaryotic cells contain diverse subcellular organelles. These organelles form distinct functional cellular compartments where different biological processes and functions are carried out. The accurate translocation of a protein is crucial to establish and maintain cellular organization and function. Newly synthesized proteins are transported to different cellular components with the assistance of protein transport machineries and complex targeting signals. Mis-localization of proteins is often associated with metabolic disorders and diseases. Compared with experimental methods, computational prediction of protein localization, utilizing different machine learning methods, provides an efficient and effective way for studying the protein subcellular localization on the whole-proteome level. Here, we present in this dissertation the bioinformatics methods for studying protein subcellular localization. We reviewed the studies of protein subcellular transport and machine learning methods in bioinformatics, presented our work on mitochondrial protein targeting prediction in plants, summarized the ongoing development of a web-resource for protein subcellular localization, and discussed the future work and development.eng
dc.format.extentxi, 123 pages : illustrationeng
dc.identifier.urihttps://hdl.handle.net/10355/67922
dc.identifier.urihttps://doi.org/10-32469/10355/67922eng
dc.languageEnglisheng
dc.publisherUniversity of Missouri--Columbiaeng
dc.relation.ispartofcommunityUniversity of Missouri--Columbia. Graduate School. Theses and Dissertationseng
dc.rightsAccess is limited to the campuses of the University of Missouri.eng
dc.titleProtein transport : bioinformatics methods for understanding protein subcellular localizationeng
dc.typeThesiseng
thesis.degree.disciplineInformatics (MU)eng
thesis.degree.grantorUniversity of Missouri--Columbiaeng
thesis.degree.levelDoctoraleng
thesis.degree.namePh. D.eng


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