Recent Submissions

  • What is the best nonsurgical therapy for carpal tunnel syndrome? 

    Aukerman, Douglas F.; Lewis, Daniel; Sullo, Elaine J. (Family Physicians Inquiries Network, 2010-12)
    Steroid injection is effective for both short- and long-term relief of symptoms in patients with carpal tunnel syndrome, while oral steroids are effective only for short-term relief (strength of recommendation [SOR]: A, ...
  • What is the best dressing for second-degree burns? 

    Folger, Jasmine; Satre, Thomas J. (Family Physicians Inquiries Network, 2010-12)
    Available evidence does not indicate a single best dressing for healing of partial thickness (second-degree) burns. Products that have shown faster wound healing compared with conventional dressings include hydrocolloids, ...
  • What are the adverse effects of aggressive glucose control in type 2 diabetes? 

    Stendahl, John C.; Power, David V. (Family Physicians Inquiries Network, 2010-12)
    Although maintaining a 10-year median A1c of 7.0% significantly decreases the rate of overall mortality and myocardial infarction (MI) over long-term follow-up (compared with a median A1c of 7.9%), more aggressive glucose ...
  • Trending toward fullness 

    Neher, Jon O. (Family Physicians Inquiries Network, 2010-12)
    This letter from the editor of Evidence Based Practice discussed the inclusion of trends in medical literature.
  • How safe and effective are meningococcal vaccines? 

    Drewelow, Rob; Simmons, Paul D. (Family Physicians Inquiries Network, 2010-12)
    The meningococcal conjugate vaccines are safe (SOR: A,based on systematic review and multiple RCTs) and immunogenic. The conjugate vaccines provide a superior immune response--particularly in younger populations--compared ...
  • How effective is rate control compared with rhythm control in preventing adverse outcomes in patients with atrial fibrillation? 

    Mead, Cody D.; Kersbergen, David (Family Physicians Inquiries Network, 2010-12)
    In the treatment of atrial fibrillation, rate control is associated with fewer adverse outcomes compared with rhythm control, with no difference in overall mortality. (SOR: A, based on consistent RCTs.)
  • eMedRef (December 2010) 

    Kamayangi, Olivia; WinklerPrins, Vincent J.; Isaacs, Brandon; Pandya, Nirav; Marshall, Robert (Family Physicians Inquiries Network, 2010-12)
    eMedRef is FPIN's electronic Medical Reference, and we are excited to share with you portions of these clinical topic reviews as they are completed or updated each month.
  • Does stopping a proton pump inhibitor cause a clinically important rebound phenomenon? 

    Fashner, Julia (Family Physicians Inquiries Network, 2010-12)
    After at least 4 weeks of therapy, cessation of proton pump inhibitors (PPIs) may cause a clinically significant increase in dyspepsia. (SOR: A, based on 2 double-blind RCTs.)
  • Does the non-pneumatic anti-shock garment (NASG) have a role in the management of postpartum hemorrhage? 

    Kerr, Nancy; Dresang, Lee T. (Family Physicians Inquiries Network, 2010-12)
    Two studies suggest that the NASG may ameliorate obstetrical hemorrhage when standard methods fail or are unavailable. More research is needed before NASG use can be routinely recommended.
  • Diving for PURLs (December 2010) 

    Sharma, Umang; Rogers, Nina Vergari; Jones, Kohar; Ewigman, Bernard; Stulberg, Debra (Family Physicians Inquiries Network, 2010-12)
    In the PURLs series, we attempt to select and summarize all new research studies that should change your clinical practice. Diving for PURLs will provide you with a synopsis of important studies that may not meet all of ...
  • Can breathing exercises lower blood pressure? 

    Kolan, Anne; Rakel, David (Family Physicians Inquiries Network, 2010-12)
    Small RCTs have shown that daily slow-breathing (<6-10 breaths per minute) exercises lower blood pressure (BP), with effects lasting up to 6 months. Due to low cost, lack of adverse effects, and relative ease in performing ...
  • Are antibiotics effective for acute flares of chronic asthma? 

    Huckabay, Christina A.; Schultz, Deborah; Hooper-Lane, Christopher (Family Physicians Inquiries Network, 2010-12)
    Early clinical trials with beta-lactam antibiotics showed no effect. However, one subsequent trial with a macrolide showed improvement in asthma symptom scores (but not forced vital capacity [FVC]) in a population in which ...
  • Are alpha-blockers effective for preventing recurrent acute urinary retention in adult men? 

    Johnson, Jessica R.; Mohundro, Brice L.; Wicker, Ann McMahon (Family Physicians Inquiries Network, 2010-12)
    Alfuzosin is not effective for the primary prevention of acute urinary retention (AUR) associated with benign prostatic hyperplasia (BPH) in adult men. (SOR: B, based on an RCT.) However, it is effective for secondary ...
  • What are effective nonpharmacologic and nonsurgical treatments for temporomandibular joint syndrome? 

    Lee, Ann; Satre, Thomas J. (Family Physicians Inquiries Network, 2010-11)
    Stabilization splint therapy, jaw postural correction physical therapy, and hyaluronate injections all appear to be effective in decreasing pain and improving function for patients with temporomandibular joint (TMJ) syndrome, ...
  • What is the most effective diagnostic tool for ADHD in school-age children in the primary care setting? 

    Mont, Meghan; Rollins, Vanessa (Family Physicians Inquiries Network, 2010-11)
    Diagnosis of attention deficit hyperactivity disorder (ADHD) in primary care is best accomplished with a combination of parent and teacher rating scales. Evidence indicates the SNAP, Vanderbilt, and Conners scales are all ...
  • Is Halloween over yet? 

    Neher, Jon O. (Family Physicians Inquiries Network, 2010-11)
    This letter from the editor of Evidence Based Practice discussed the use of ghostwriters in producing medical literature.
  • Is melatonin effective for patients with secondary sleep disorders? 

    Endrikhovskaya, Liubov; Proulx, Anne M. (Family Physicians Inquiries Network, 2010-11)
    Melatonin does not affect sleep-onset latency in patients with secondary sleep disorders. (SOR: B, based on a meta-analysis with inconsistent findings.) Melatonin minimally increases sleep efficiency and total sleep time, ...
  • Is levalbuterol superior to racemic albuterol for treating acute childhood asthma? 

    Murphy, Pilar Z.; Vinson, Eli (Family Physicians Inquiries Network, 2010-11)
    In emergency department management of acute childhood asthma, the number of nebulizer treatments required using either levalbuterol or racemic albuterol is not statistically different. (SOR: B-, based on a single RCT.) ...
  • Is combined fish oil and statin therapy in patients with hypertriglyceridemia more effective than statins alone? 

    Cournoyer, William J.; Kraus, Connie (Family Physicians Inquiries Network, 2010-11)
    The addition of 4 mg/d prescription omega-3 fatty acids to a statin is more effective than a statin alone in lowering both triglyceride levels and non-high-density lipoprotein (non-HDL) cholesterol in patients with ...
  • Is clopidogrel plus aspirin superior to aspirin alone for primary prevention of cardiovascular outcomes among patients with multiple risk factors? 

    Stang, Christopher; Gauer, Robert (Family Physicians Inquiries Network, 2010-11)
    The addition of clopidogrel to aspirin therapy is not superior to aspirin therapy alone for primary prevention. In addition, medical therapy with a combination of clopidogrel and aspirin increases the risk of moderate to ...

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