The Family Physicians Inquiries Network is a community of inclusion that is committed to engaging every organization and individual who wishes to join us in revolutionizing primary care practice. The primary focus of the network is developing valuable benefits for family medicine departments, family practice residency programs and medical librarians/health sciences libraries.

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Recent Submissions

  • Should RAAS blockade therapy be continued in patients with advanced renal disease? 

    Pham, Kim; Beyer, Carli; Guthmann, Rick (Family Physicians Inquiries Network, 2023-04)
    Q: Should RAAS blockade therapy be continued in patients with advanced renal disease? Evidence-based answer: PROBABLY. Renin-angiotensinaldosterone system (RAAS) blockade therapy should be continued in most patients with ...
  • Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? 

    Reddy, Vinay; Allison, James; Mounsey, Anne; Guthmann, Rick (Family Physicians Inquiries Network, 2023-06)
    Q: Is there benefit to adding ezetimibe to a statin for the secondary prevention of CVD? Evidence-based answer: YES. In patients with known cardiovascular disease (CVD), ezetimibe with a statin decreases major adverse ...
  • Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? 

    Dresang, Lee; Vellardita, Lia; Guthmann, Rick (Family Physicians Inquiries Network, 2023-03)
    Q: Should antenatal testing be performed in patients with a pre-pregnancy BMI ≥ 35? Evidence-based answer:Possibly. Elevated BMI is associated with an increased risk for stillbirth (strength of recommendation [SOR], B; ...
  • Is low-dose naltrexone effective in chronic pain management? 

    Radi, Roxanne; Huang, Harriet; Rivera, Jason; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-09)
    Q: Is low-dose naltrexone effective in chronic pain management? Evidence-based answer: YES. Low-dose naltrexone is as effective as amitriptyline in the treatment of painful diabetic neuropathy and has a superior safety ...
  • Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? 

    Wen, Frances K.; Bigelow, Simone; Crosby, Kimberly; Reeder, Raye; Hoberecht, Toni; Moreau, Emrys; Guthmann, Rick (Family Physicians Inquiries Network, 2023-07)
    Q: Does use of continuous or flash glucose monitors decrease hypoglycemia episodes in T2D? Evidence-based answer: NO. In adults with insulin-treated type 2 diabetes (T2D), continuous glucose monitoring (CGM) and flash ...
  • Does regular walking improve lipid levels in adults? 

    Hatchell, Kayla; Chin, Emily; Vukelic, Brian; Fortenberry, Katherine; Ose, Dominick; Taylor, Eliza; Goossen, Rachel; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: Minimally. Regular moderateintensity walking for a period of 4 or more weeks minimally decreased total cholesterol (TC) and low-density lipoprotein (LDL) levels by about 7 mg/dL in women with ...
  • Does physical exercise reduce dementia-associated agitation? 

    Jabbour, Katarzyna; Wilson, Lynn M.; Mathieu, Susan S.; Keister, Drew; Guthmann, Rick (Family Physicians Inquiries Network, 2023-01)
    Q: Evidence-based answer: not consistently. Physical exercise demonstrates inconsistent benefit for neuropsychiatric symptoms, including agitation, in patients with dementia (strength of recommendation: b, inconsistent ...
  • Does hormone replacement therapy prevent cognitive decline in postmenopausal women? 

    Gates, Madeline; Beagle, Melissa; Bull, Lauren; Radi, Roxanne; Lyon, Corey; DeSanto, Kristen; Guthmann, Rick (Family Physicians Inquiries Network, 2023-05)
    Q: Evidence-based answer: NO. Hormone replacement therapy (HRT) does not prevent cognitive decline in postmenopausal women—and in fact, it may slightly increase risk (strength of recommendation, A; systematic review, ...
  • How does gender-affirming hormone therapy affect QOL in transgender patients? 

    Wilhelm, Sarah; Kelsberg, Gary; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-12)
    Q: How does gender-affirming hormone therapy affect QOL in transgender patients? Evidence-based answer: There are modest effects on depression but not anxiety. Gender-affirming hormone therapy (GAHT) is associated with ...
  • How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? 

    Boden, Brandi; Buescher, Brittany; Kim, Amanda; Neher, Jon O.; Safranek, Sarah; Guthmann, Rick (Family Physicians Inquiries Network, 2022-11)
    Q: How accurate is transcutaneous bilirubin testing in newborns with darker skin tones? Evidence-based answer: Fairly accurate. Photometric transcutaneous bilirubin (TcB) testing may overestimate total serum bilirubin (TSB) ...
  • Which anticoagulant is safest for frail elderly patients with nonvalvular A-fib? 

    Earwood, J. Scott; Wilkie, Justin L.; Fernandez-Vasquez, Jennifer L. (Family Physicians Inquiries Network, 2022-11)
    Consider apixaban, which demonstrated a lower adverse event (AE) rate than warfarin regardless of frailty status, for anticoagulation treatment of older patients with nonvalvular atrial fibrillation (AF); by comparison, ...
  • What BP target is appropriate for pregnant patients with mild chronic hypertension? 

    Lombardo, Cynthia; Morris, Laura (Family Physicians Inquiries Network, 2023-01)
    Treat mild chronic hypertension during pregnancy to a target of [greater than] 140/90 mm Hg to reduce the risk for adverse pregnancy outcomes.
  • Put down the electronics after a concussion? 

    Rabaza, Cristina; Piggott, Cleveland (Family Physicians Inquiries Network, 2023-01)
    Advise your teenaged and young adult patients with concussion to avoid electronic screens in the first 48 hours after a concussion to minimize time to symptom resolution.
  • Is self-administered DMPA an answer to contraception access in the post-Roe era? 

    Nakaishi, Lindsay; Castelli, Gregory (Family Physicians Inquiries Network, 2023-03)
    Consider prescribing self-administered subcutaneous depot medroxyprogesterone acetate (DMPA) for contraception instead of provider-administered DMPA. Self-administration improves contraception continuation rates without ...
  • Is combination pharmacotherapy effective for patients with acute depression? 

    Cardon, Brock; Schirding, Stephanie (Family Physicians Inquiries Network, 2023-04)
    Use a combination of a presynaptic α2-autoreceptor antagonist (eg, mirtazapine or trazodone) and a monoamine reuptake inhibitor (eg, selective serotonin reuptake inhibitor [SSRI], serotonin-norepinephrine reuptake inhibitor ...
  • Consider this tool to reduce antibiotic-associated adverse events in patients with sepsis 

    Mott, Timothy; Orme, Zachary (Family Physicians Inquiries Network, 2023-01)
    For patients hospitalized with sepsis, consider procalcitonin (PCT)-guided early discontinuation of antibiotic therapy for fewer infection-associated adverse events (AEs).
  • Consider this SGLT2 inhibitor for patients with HF with preserved ejection fraction 

    Produttur, Sanketh; Castelli, Gregory (Family Physicians Inquiries Network, 2022-12)
    Consider adding empagliflozin 10 mg to usual therapy to reduce hospitalization of symptomatic patients with heart failure with preserved ejection fraction (HFpEF; EF > 40%) and an N-terminal pro–B-type natriuretic peptide ...
  • Does an early COPD diagnosis improve long-term outcomes? 

    Bernet, Dan; Randolph, Charles; Neher, Jon O.; Safranek, Sarah (Family Physicians Inquiries Network, 2022-10)
    Q Does an early COPD diagnosis improve long-term outcomes? Evidence-based answer: It depends. A diagnosis of chronic obstructive pulmonary disease (COPD) made using screening spirometry in patients without symptoms does ...
  • Noncardiac inpatient has acute hypertension: Treat or not? 

    Marshall, Robert C.; Thiel, Derrick J.; Samar, Haroon (Family Physicians Inquiries Network, 2022-09)
    A retrospective study found more harm than benefit from treating elevated blood pressure in hospitalized noncardiac patients.
  • A "no-biopsy" approach to diagnosing celiac disease 

    Mott, Timothy; Gray, Carrie; Storey, Jon (Family Physicians Inquiries Network, 2022-10)
    This noninvasive alternative to the diagnostic gold standard may cut risk and expense for adult patients.

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