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    • University of Missouri-Columbia
    • College of Agriculture, Food and Natural Resources (MU)
    • Division of Food Systems and Bioengineering (MU)
    • Department of Biological Engineering (MU)
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    Monte Carlo Model for Studying the Effects of Melanin Concentrations on Retina Light Absorption

    Guo, Ya, 1977-
    Yao, Gang, Ph. D.
    Lei, Bo
    Tan, Jinglu, 1958-
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    [PDF] MonteCarloModelStudyingEffectsMelanin.pdf (593.7Kb)
    Date
    2008-02
    Format
    Article
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    Abstract
    We developed a Monte Carlo model to calculate light absorption in human and mouse retinas. The retina was modeled as a five-layer spherical structure. The effects of melanin concentrations in the retinal pigment epithelium (RPE) and choroid layer were studied. Variations of blood content in choroid were also considered in the simulation. Our simulation results indicated that light absorption in neural retina was at least 20% higher in albino subjects than in pigmented subjects under both photobleaching and dark-adapted conditions. It can be four times higher at optical wavelengths corresponding to minimal hemoglobin absorption. The elevated absorption at neural retina was attributed to the light backscattered from the choroid and sclera layers. This simulation model may provide useful information in studying light-induced retina damage.
    URI
    http://hdl.handle.net/10355/9043
    Citation
    Journal of the Optical Society of America, Vol. 25, Issue 2, pp. 304-311 (2008).
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    • Biological Engineering publications (MU)

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