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Cruciate ligament pathogenesis and its role in the initiation and progression of osteoarthritis
(University of Missouri--Columbia, 2008)
The pathogenesis of cruciate ligament disease and how it may be linked to the initiation and progression of osteoarthritis were investigated using in vitro and in vivo models. Normal and diseased tissues were initially ...
Decreasing perinatal bovine leukosis virus infection in calves
(University of Missouri--Columbia, 2006)
Bovine leukosis virus (BLV) is an oncogenic retrovirus of cattle that causes lymphosarcoma in a proportion of infected individuals. Currently the United States estimates are that 44% of dairy cattle and 10% of beef cattle ...
The role of load in initiation and progression of cartilage pathology
(University of Missouri--Columbia, 2007)
Articular cartilage is primarily responsible for dissipation of load in diarthrodial joints. Load plays a critical role in maintaining cartilage health, but can also be a primary contributing factor in cartilage disease ...
Phylogenetic characterization of canine distemper viruses detected in naturally infected North American dogs
(University of Missouri--Columbia, 2006)
coding for hemagglutinin (H) and fusion (F) proteins, while partial gene sequencing was peformed for the viral phosphoprotein (P). A total of 4,508 bases were sequenced for the CDV strains detected. Two strains were found to have identical sequences...
Use of the veterinary medical database to update the veterinary oncology literature
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In this dissertation we discuss the Veterinary Medical Database and how it can be used to perform epidemiological studies in the veterinary oncology ...
The identification of a diagnostic biomarker panel for canine osteoarthritis
(University of Missouri--Columbia, 2010)
A novel biomarker panel for the diagnosis of early osteoarthritis (OA) in canines has been identified. This panel consists of monocyte chemoattractant protein 1 (MCP1), interleukin-8 (IL-8), keratinocyte-derived chemoattractant ...
Adding pieces to the monocytic ehrlichiosis puzzle : treatment, etiology and protection with a canine model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Infections with Ehrlichia canis cause Canine Monocytic Ehrlichiosis (CME), a disease which causes morbidity and mortality of dogs worldwide. Currently, ...
DLC1 as a comparative epigenetic biomarker for radiotherapy of Non-Hodgkin's lymphoma
(University of Missouri--Columbia, 2007)
of cytosine followed by guanine in silencing gene expression. Such hypermethylated genes may serve as markers of disease, markers of prognostic groups, or targets for therapy. In this series of experiments, evidence of DNA hypermethylation was identified...
In vitro synovial fibrochondrogenesis for meniscal tissue engineering
(University of Missouri--Columbia, 2008)
A series of in vitro studies were performed to evaluate the fibrochondrogenic potential of synovial membrane cells, for the long term goal of inducing meniscal fibrocartilage healing and regeneration. The first study ...
Diagnosis, epidemiology and immunologic consequences of copper deficiency in calves
(University of Missouri--Columbia, 2006)
Copper is an essential micronutrient. Copper deficiency has been associated with disease states that decrease commercial beef production. Clinical manifestations of copper disease include anemia, diarrhea, long bone ...
Characterization of skeletal muscle in mouse models of osteogenesis imperfecta and myostatin deficiency
(University of Missouri--Columbia, 2010)
) and moderately severe (oim/oim) OI for evidence of inherent muscle pathology. Four month old oim/oim mouse muscles were generally smaller, had weaker muscles and an inability to sustain Po for the 300 ms testing duration for specific muscles; +/oim mice had a...
Targeting the bombesin subtype 2 receptor for the diagnosis and treatment of metastatic prostate cancer
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In the United States, prostate cancer is the most commonly diagnosed cancer and the third leading cause of cancer related deaths in men. With early ...
Large scale CpG island methylation profiling of small B cell lymphoma
(University of Missouri--Columbia, 2008)
DNA methylation plays a significant role in cellular differentiation and biologic activity through silencing of gene expression and also appears to be a factor in the progression of different types of cancer, including ...
Interactions of porcine reproductive and respiratory syndrome virus with innate immune responses
(University of Missouri--Columbia, 2005)
PRRSV replication. This study also provided evidence of a possible involvement of NF-[kappa]B and ROS in apoptosis induced by PRRSV....
The role of macrophages and anti-viral antibodies in West Nile virus pathogenesis
(University of Missouri--Columbia, 2006)
Since the introduction of West Nile virus into the United States in 1999, the virus has spread throughout the continental territory of the United States and it is suspected that the virus has moved present into Mexico and ...