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Small molecule-based approaches toward elucidation of structure and properties of abasic site-derived interstrand DNA crosslinks /
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Damage to DNA is both a naturally occurring and environmentally induced process that can have serious biological consequences, such as mutation and ...
Preparation of polymeric boron-containing nanoparticles by emulsion polymerization for application in boron neutron capture therapy (BNCT)
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Boron neutron capture therapy (BNCT) is based on the nuclear capture reaction of isotope [superscript 10]B irradiated by low energy thermal neutron ...
Hypoxia-selective antitumor prodrugs and fluorescent probes
(University of Missouri--Columbia, 2016)
Hypoxia-selective antitumor prodrugs utilize the unique feature of most tumors -- hypoxia (low oxygen concentration), for therapeutic purpose and are widely studied in preclinical and clinical stages. Tirapazamine (TPZ, ...
Fluorescent chemosensors for the detection of biological amines
(University of Missouri--Columbia, 2014)
Chemical sensing has become an important field for the study of bioanalytes and provides key information pertaining to disease pathogenesis, and the physiological mechanisms underlying cellular processes. Discussed herein ...
Surface chemistry studies of carbon dioxide with magnesium oxide and titanium dioxide
(University of Missouri--Columbia, 2016)
There is significant interest in methods to aid in the removal of carbon dioxide from our environment. The methods range from sequestration to catalytic transformations. In sequestration, CO2 is collected from emission ...
On the reaction in a mixture of hydrous ferrous ammonium sulfate and sodium chloride
(University of Missouri--Columbia, 1917)
In connection with work in this laboratory it had been observed that a reaction takes place between hydrous ferrous ammonium sulfate and sodium chloride when they are intimately mixed and kept in tightly closed bottles, ...
LC-MS/MS method development for quantitative analysis of cyanogenic glycosides in elderberry and lipid peroxidation products in mice
(University of Missouri--Columbia, 2021)
Cyanogenic glycosides (CNGs) are naturally occurring plant molecules (nitrogenous plant secondary metabolites) which consist of an aglycone and a sugar moiety. Hydrogen cyanide (HCN) is released from these compounds following ...
Coulomb explosions dynamics
(University of Missouri--Columbia, 2022)
Chemical reaction dynamics studies emerged with the advent of quantum mechanical theories in 1920s which have the capability of predicting the atomic motions by calculating potential energy surfaces. Experimental studies ...
Method development for the analysis of nuclear forensic signatures with ICP-MS
(University of Missouri--Columbia, 2022)
Nuclear forensic analysis is a field of analytical chemistry that focuses specifically on analyzing signatures of nuclear material for criminal investigation. Promising nuclear forensic signatures include rare earths element ...
Formation and properties of endogenous adducts and crosslinks generated by amine-catalyzed strand cleavage at an AP site in duplex DNA
(University of Missouri--Columbia, 2022)
Abasic sites in DNA are a very common lesion. They are formed spontaneously and in the presence of biological amines, enzymes, and proteins. If unrepaired, abasic sites lead to DNA strand breaks and crosslinks. This thesis ...
Development of novel fluorescent sensors for targeting biologically relevant molecules
(University of Missouri--Columbia, 2023)
[EMBARGOED UNTIL 8/1/2024] Fluorescence sensing plays an important role in a wide variety of fields such as medical science, chemical biology, food industry and so on. Several new fluorescent probes were developed to target ...
Investigation of the thermostability and activity of biomolecules in bio-friendly deep eutectic solvents
(University of Missouri--Columbia, 2023)
The solvent environment of a biomolecule is critical to its optimal performance in various scenarios, including biocatalysis, drug delivery, therapeutics, and biosensing. This dissertation mainly discusses the implementation ...
Biomimetic reactions relevant to the study of abasic sites in DNA
(University of Missouri--Columbia, 2020)
Abasic (Ap) sites represent the most common form of DNA damage in mammalian cells. With steady state levels of 10,000 sites existing in each cell, there is a dire need to study these noxious biological electrophiles. While ...
Investigation and modeling of carbon dioxide adsorption within porous materials
(University of Missouri--Columbia, 2023)
Mathematics has long been my special interest. With that in mind, if I make any operations which are unobvious to the reader, I deeply apologize. I often forget that, even within the STEM fields, not everyone enjoys spending ...
Near infrared fluorescent sensors for selective glucose recognition
(University of Missouri--Columbia, 2021)
With diabetes becoming a major health concern worldwide, it is growing clear that novel technologies are needed to monitor blood glucose in a manner that is continuous, real-time, and long-term --all while alleviating the ...
Lc-ms/ms method development for quantitation of nicotine in toenails as a biomaker for secondhand smoke and standard lipoprotein mimetic models
(University of Missouri--Columbia, 2021)
Passive smoke or (secondhand smoke) is defined as when a non-smoker is unintentionally exposed to a smoking environment from cigarettes, cigars, or pipes. Passive smoke can result in adverse health effects leading to heart ...
The adsorption of environmental pollutants in gas and aqueous media utilizing nano-scale materials
(University of Missouri--Columbia, 2021)
In this body of work, the synthesis and characterization of several nanoporous materials have been described, as well as the application of these materials towards environmentally positive means. Largely, this work involves ...
Synthesis, characterization, and reactivity of actinide complexes bearing An-E bonds (An = Th, U; E = P, As)
(University of Missouri--Columbia, 2021)
Organoactinide complexes bearing An-E (An = Th, U; E = P, As) bonds were synthesized and reactivity studies were performed with various unsaturated and industrially/environmentally relevant small molecules in an effort to ...
(4+3)-cycloaddition chemists of oxidopyridinium ions and related study
(University of Missouri--Columbia, 2019)
The (4+3)-cycloaddition reaction is a cycloaddition between a 4-atom species and a 3-atom species to form a seven-membered ring. This reaction results in the formation of seven-membered rings. Our research expanded the ...
Mixed quantum-classical simulations of intersystem crossing in the exit channel and vibrational adaptive sampling configuration interaction
(University of Missouri--Columbia, 2022)
A computational study using mixed quantum-classical surface hopping simulations was performed for the reaction of O(3P) with dimethylamine and trimethylamine. These reactions produce an OH radical and while the OH radical ...