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Now showing items 101-120 of 295
Quantitative Profiling of S-Nitrosylated Proteins in Parkinson's Disease Paradigms for the Effects of Botanical Phenolics [abstract]
(2010-02)
A convergent feature for most aging-related neurological diseases, such as Parkinson's Disease (PD), is excessive generation of free radicals - reactive nitrogen and oxygen species, which can contribute to neuronal cell ...
Clinical Translation of Nanopharmaceuticals for Cancer Therapy [abstract]
(2010-02)
The most recent study involving 77,000 North American men has shown that regular prostate specific antigen (PSA) screening did not provide accurate diagnosis of prostate cancer and therefore did not save lives of cancer ...
Temporal trends in the management of severe hyperglycemia among patients hospitalized with acute myocardial infarction [abstract]
(2010)
Background: Elevated blood glucose (BG) is associated with an adverse prognosis in acute myocardial infarction (AMI) patients. While guidelines recommend insulin therapy to lower markedly elevated BG in AMI patients, it ...
Mechanism-based Inhibitor of Matrix Metalloproteinase-9 Rescues Brain from Focal Cerebral Ischemia-induced Damage and Improve Neurological Outcomes in Mice [abstract]
(2010-02)
Stroke is the third leading cause of death in the US and the primary cause of long-term disability. Acute ischemic stroke, the most common form of stroke, is caused by clotting in the cerebral arteries leading to brain ...
Skeletal Muscle - Bone Crosstalk Regulating Osteocyte Function [abstract]
(2010-03)
Osteocytes are thought to be the primary cell in bone that responds to mechanical loading and the traditional view is that skeletal muscle's role relative to bone is in the application of those loads. We have hypothesized ...
UMKC Center of Excellence in the Study of Dental and Musculoskeletal Tissues (CEMT) [abstract]
(2010-03)
Diseases of mineralized tissues such as bone and teeth or of the muscles that control bone movement result in significant health costs in terms of suffering, loss of work and productivity, and even death. There is a ...
Cancer stem cells in malignant peripheral nerve sheath tumor: Biology and therapeutic ramifications [abstract]
(2010-03)
Although monoclonal in origin, most tumors appear to contain heterogeneous populations of cancer cells. One possible explanation of this tumor heterogeneity is that human tumors are not merely monoclonal expansions of a ...
Engineering Optimal Islets for Transplantation for Type 1 Diabetes [abstract]
(2010-03)
Islet transplantation offers an improvement in the quality of life for those suffering from type 1 diabetes. It is found that islet cells may die during or soon after transplantation. Studies in our lab have shown that ...
Early Breast Cancer Detection Using Fluorescence Mediated Tomographic Imaging [abstract]
(2010)
Development of reliable technologies for early detection and screening of breast cancer is significant since the overall accuracy of traditional mammography remains low for diagnosis of benign and malignant lesions. In ...
Cytotoxic Oleanane-type Triterpenen Saponins with N-acetyl Sugar from Albizia inundata [abstract]
(2010)
Bioassay-guided fractionation of a CH2Cl2-MeOH extract of the aerial part of Albizia inundata , collected in Argentina, resulted in the isolation of two new oleanane-type triterpene saponins with N-acetyl sugar (1, 2) and ...
Maternal exercise during pregnancy and the influences on cardiac autonomic control [abstract]
(2010)
Background: Our previous research found decreased fetal heart rate (fHR) and increased heart rate variability (HRV) as a result of regular maternal aerobic exercise. These results suggest exposure to exercise throughout ...
A Novel Method to Monitor Sequential Displacement of Capped Ligands in Gold Nanoparticles [abstract]
(2010-02)
Nanochemistry of ligand displacement reactions has attracted much attention in recent years for the development of myriad of new gold nanomaterials. Gold nanoparticles have shown applications ranging from tumor imaging ...
Dose escalation safety study of Nanotax® in dogs [abstract]
(2010)
The goal of this project is to determine the suitability of CritiTech's existing formulation of fine-particle paclitaxel, Nanotax®, for the treatment of spontaneously-occurring cancer in dogs. The rationale behind this ...
Antitumor withanolides from Withania somnifera [abstract]
(2010)
Surgery, University of Kansas Medical Center, Kansas City, Kansas 66160
Withania somnifera L. Dunal (Solanaceae) is an Indian plant commonly known as “ashwagandha”. This traditional plant has been used in Ayurvedic medicine ...
A Comparative Study between Antibody and Peptide Conjugated Gold Nanoparticles for In Vivo Targeting of EGFR in Pancreatic Cancer Bearing Mice Models [abstract]
(2010-03)
Pancreatic cancer is the fourth leading cause of cancer related deaths in the United States due to its severe aggressiveness and lethal malignancy. Epidermal Growth Factor Receptor (EGFR) is over expressed in more than 95% ...
Derivation and characterization of LIF and FGF2 dependent Porcine Induced Pluripotent Stem Cells [abstract]
(2010-02)
Authentic embryonic stem cells (ESC) have probably never been derived from the inner cell mass (ICM) of pig, despite over 25 years of effort. Recently, several groups, including ours, have reported derivation of induced ...
Shock Wave Based Cell Transfection and Fluorescent Organosilicate Nanoparticles for Targeted Drug Delivery [abstract]
(2010)
Nanotechnology is a multidisciplinary field that has applications in life sciences, alternative energy, national defense, and electronics. In the field of medicine, nanotechnology may enable intelligent drug delivery using ...
Development and characterization of fluorescent dye-doped nanoparticles with enhanced fluorescence intensity and photostability [abstract]
(2010)
We report the development of fluorescent dye doped organosilicate nanoparticles (DOSNPs) synthesized from poly-methylsilsesquioxane(PMSSQ), resulting in high fluorescence intensity and excellent photostability. The surface ...
Novel Nanostructured Organosilicate Nanoparticle Coatings for Chem-Bio Sensing [abstract]
(2010-03)
We present novel nanostructured organosilicate particulate based films and demonstrate that these materials have a great potential for chemical-biological sensor development. With unprecedented high surface areas (> 1400 ...
Self-Aligned Microchip Device for Automated Measurement of Quantal Exocytosis [abstract]
(2010-02)
Neurons and endocrine cells secrete neurotransmitters and hormones as a method for cell-to-cell communication through the process of exocytosis. Disruption of exocytosis underlie neurological disorders such as Parkinson's ...