What are the most effective treatments for bacterial vaginosis in nonpregnant women?

Abstract

Either oral or vaginal metronidazole or vaginal clindamycin provides equivalent treatment for bacterial vaginosis in nonpregnant women. Oral clindamycin 300 mg twice daily for 7 days is an effective alternative. There is conflicting evidence regarding the efficacy of a single 2-g dose of oral metronidazole. Ofloxacin 200 mg or 300 mg twice daily is less effective but could be considered for women with intolerance to metronidazole or clindamycin. Overall recurrence rates of up to 30% have been reported. (Grade of recommendation: A, based on systematic reviews and randomized controlled trials)