Browsing Graduate School - MU Theses and Dissertations (MU) by Thesis Department "Medical Pharmacology and Physiology (MU)"
Now showing items 41-60 of 67
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Molecular mechanisms controlling endothelial cell-pericyte tube coassembly during vascular morphogenesis
(University of Missouri--Columbia, 2010)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] From the onset the goal of this thesis work was to determine the role that a novel class of growth factors, i.e. hematopoietic cytokines, was playing ... -
Molecular mechanisms of tumor invasion in three-dimensional collagen matrices
(University of Missouri--Columbia, 2007)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Cancer remains a significant cause of morbidity and mortality worldwide, and invasion and metastasis substantially contribute to poor prognosis and ... -
Molecular physiology and pharmacology of the CFTR chloride channel
(University of Missouri--Columbia, 2012)Cystic fibrosis transmembrane conductance regulator (CFTR) is the only ATP binding cassette (ABC) protein that functions as an ion channel. The clinical importance of CFTR lies in the fact that its malfunction causes the ... -
Myofibrillar regulatory mechanisms of stretch activation in mammalian striated muscle
(University of Missouri--Columbia, 2017)Stretch activation is described as a delayed increase in force after an imposed stretch. This process is essential in the flight muscles of many insects and is also observed, to some degree, in mammalian striated muscles. ... -
New gating states of Cystic Fibrosis transmembrane conductance regulator discovered via studying pathogenic mutations, pharmacological reagents and ATP analogs.
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cystic Fibrosis (CF), caused by the loss of function in the gene for the protein cystic fibrosis transmembrane conductance (CFTR), is one of the most ... -
Non-enzymatic glycation modifies binding of fibronectin to arteriolar smooth muscle cells /
(University of Missouri--Columbia, 2016)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] -
P2Y[subscript 2] nucleotide receptor up-regulation and function in submandibular gland epithelium
(University of Missouri--Columbia, 2005)Sjögren's syndrome (SS) is an autoimmune disease that specifically targets exocrine glands, including salivary glands, and results in an impairment of secretory function. P2Y₂ nucleotide receptors for extracellular ATP ... -
Peroxynitrite, pumps and perivascular adipose tissue : studies across the physiological spectrum
(University of Missouri--Columbia, 2008)Peroxynitrite (ONOO-) is a reactive nitrogen species produced when nitric oxide (NO) and superoxide (O2-) react. In vivo studies suggest that reactive oxygen species and perhaps peroxynitrite can influence Na,K-ATPase (Na ... -
Phenotypically different cells in the nucleus of the solitary tract : expression of group I metabotropic glutamate receptors and activation by baroreflexes
(University of Missouri--Columbia, 2008)Modulation and integration of visceral and central afferent information occurs in the nucleus of the solitary tract (NTS). The NTS is a heterogeneous nuclear region that contains afferent terminals, interneurons, and ... -
Physical inactivity induced dysregulation of skeletal muscle and adipose tissue metabolism
(University of Missouri--Columbia, 2005)There has been a precipitous decline in the daily physical activity in humans that has been accompanied by an epidemic rise in the incidence of obesity and type II diabetes. This rapid decline in physical activity in humans ... -
Preload-induced changes in systolic and diastolic performance in the aged and young murine heart
(University of Missouri--Columbia, 2015)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The aged heart exhibits modifications limiting cardiac performance. The purpose of this study was to test the hypothesis that aged hearts exhibit ... -
Rats selectively-bred for low and high voluntary running: co-selected traits and the effects of voluntary running on the dentate gyrus transcriptome
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The Booth lab at the University of Missouri has selectively-bred Wistar rats for low (LVR) and high (HVR) voluntary running behavior as a model for ... -
Receptor for advanced glycation end-products blockade improves endothelial dependent vascular function in atherosclerotic mice
(University of Missouri--Columbia, 2012)Atherosclerosis is a progressive inflammatory disease that is present in large vessels in the body. We hypothesized that either adiponectin treatment or soluble Receptor for Advanced Glycation Products (sRAGE) treatment ... -
The role and mechanisms of ambient fine particulate matter exposure in cardiac dysfunction in mice
(University of Missouri--Columbia, 2022)Ambient fine particulate matter (PM) exposure associates with an increased risk of cardiovascular diseases (CVDs). Oxidative stress and inflammation are considered important mechanisms for the development and progression ... -
A role for insulin in the central control of sympathetic nerve activity in humans
(University of Missouri--Columbia, 2010)Although well recognized for the regulation of peripheral metabolism, an emerging body of literature has begun to also establish a role for insulin in neural-cardiovascular control. In this regard, direct administration ... -
The role of adipose tissue in the regulation of endothelial function in type 2 diabetes : mechanisms and therapeutic implications
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The prevalence of obesity and diabetes is rising dramatically worldwide. Increased adiposity is associated with elevated cardiovascular risk factors, ... -
The role of perivascular adipose tissue and infiltrating macrophages in vascular dysfunction with inflammatory bowel disease
(University of Missouri--Columbia, 2022)Historically, adipose tissue (AT) throughout the body has been categorized as either brown adipose tissue (BAT) or white adipose tissue (WAT). These categories are determined by color, physical characteristics, and ... -
Role of plasminogen activator inhibitor-1 in the regulation of mitochondrial function in vascular smooth muscle cells
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Plasminogen activator inhibitor-1 (PAI-1), a serine protease inhibitor produced by vascular smooth muscle cells (VSMCs) and other cells, triggers metabolic dysfunction and cell senescence in ... -
The role of serum-glucocorticoid-regulated kinase (SGK1) in arterial reactivity
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 8/1/2024] Objective: In the vascular system, aldosterone exerts several actions via genomic and non-genomic pathways through MR receptor-dependent/independent mechanisms. Aldosterone exerts its effect by ... -
Role of T-type Ca²⁺ channels in lymphatic pacemaking /
(University of Missouri--Columbia, 2017)Lymphatic smooth muscle (LSM) contracts spontaneously, actively returning interstitial fluid through a network of lymphatic capillaries and collecting lymphatic vessels to the great veins. Dysfunctional lymphatic contractions ...