Browsing Theses and Dissertations (MU) by Thesis Department "Biochemistry (MU)"
Now showing items 41-60 of 97
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Investigating the role of arginine 21 in the structure and function of human [alpha]a-crystallin
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cataractogenesis in the eye lens occurs as a result of protein aggregation. Of the multiple mutations in [alpha]A-crystallins associated with the ... -
Investigating the roles and functions of plasma membrane E3 ligases and MKP1 in plant immunity
(University of Missouri--Columbia, 2021)When a plant encounters a pathogen, a complex set of responses occurs on both sides of the interaction. In a process known as pattern-triggered immunity (PTI), the plant uses plasma membrane (PM)-localized proteins, or ... -
Investigation of the initial steps of jasmonic acid biosynthesis and a study of differential regulation of the ribosomal association of mRNA transcripts in jasmonate-dependent wound response
(University of Missouri--Columbia, 2020)Jasmonic acid is an oxylipin derived hormone that is responsible for regulating plant responses against various abiotic and biotic stressors and it also serves important roles in plant development. Jasmonic acid once ... -
Kinetic study of histidine kinase CheA in bacterial chemotaxis
(University of Missouri--Columbia, 2017)Histidine kinase CheA is central to signaling in bacterial chemotaxis. This kinase is responsible for the phosphorylation of two response regulators, CheY and CheB. CheY controls flagellar rotation and thus motility. CheB ... -
Making others happy : the best route to one's own happiness?
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] There are many positive psychology interventions whose aim is to help people improve their levels of happiness and well-being, some of which work ... -
Mass spectrometry-based seed allergen quantification and applications in seed quality assessment
(University of Missouri--Columbia, 2012)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Incidences of food allergies have doubled in the past two decades, becoming a worldwide public health concern. Together, tree nuts and peanuts cause ... -
Mechanisms of salivary gland cell proliferation in vitro by P2Y2R activation
(University of Missouri--Columbia, 2012)Sjögren's syndrome (SS) and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction. Salivary gland regeneration has been considered to be a very promising approach for restoring ... -
Membrane interactions with membrane type 1 matrix metalloproteinase
(University of Missouri--Columbia, 2018)Membrane type 1 matrix metalloproteinase (MT1-MMP) is essential to a myriad of extracellular activities including tumor cell migration and angiogenesis. At the cell surface, MT1-MMP is a major factor in the proteolysis of ... -
Methods of partitioning, biogenesis, and selecting for natural and engineered CoA-RNA
(University of Missouri--Columbia, 2023)More than a decade ago, RNAs with NAD+, CoA, and acylated CoA caps were identified. Since then, studies have described NAD+'s protective, cap-like function in bacteria and its role in promoting mRNA degradation in eukaryotic ... -
The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2010)Human Immunodeficiency Virus (HIV) reverse transcriptase (RT) is the most common molecular target of current HIV treatments. Oligonucleotide aptamers bind and inhibit the RNA- and DNA-dependent polymerization activities ... -
Modification of host and bacterial proteomes during host-pathogen interactions
(University of Missouri--Columbia, 2011)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Plant cells, such as those of Arabidopsis thaliana, detect the presence of bacteria through cell-surface receptors that recognize microbial-associated ... -
Molecular mechanisms of enzyme dysfunction in human phosphoglucomutase-1 deficiency
(University of Missouri--Columbia, 2019)Human phosphoglucomutase-1 (PGM1) belongs to the [alpha]-D-phosphohexomutase superfamily, an ancient lineage of enzymes critical for carbohydrate metabolism. PGM1 catalyzes the interconversion of glucose-1-phosphate and ... -
Monosaccharide-binding of cystic fibrosis pseudomonas aeruginosa: glycopolymer preparations, methods development and phenotype assessment
(University of Missouri--Columbia, 2014) -
The musculoskeletal effect of exercise and soluble activin receptor type 2b in mouse models of osteogenesis imperfecta
(University of Missouri--Columbia, 2017)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Osteogenesis Imperfecta (OI) is a heritable connective tissue disorder primarily due to mutations in the type I collagen containing tissues, such as ... -
Neuroprotective roles of the P2Y[subscript 2] nucleotide receptor
(University of Missouri--Columbia, 2014)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is the most prevalent neurodegenerative disease. AD is an important disease to study because of the high cost of care for ... -
Nitrate and nitrite growth inhibition of Desulfovibrio strains
(University of Missouri--Columbia, 2014)Sulfate-reducing bacteria, common non-pathogenic soil bacteria, have the ability to limit the movement of toxic heavy metals from one environmental site to another by keeping those metals from dissolving in water. Limiting ... -
A novel role for the ATP7A copper transporter in cancer
(University of Missouri--Columbia, 2018)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is a trace metal with a ready capacity to gain or donate electrons. This property is harnessed by numerous enzymes to perform vital functions ... -
On the role of the purinergic receptor P2Y2R in oral cancer and salivary gland dysfunction
(University of Missouri--Columbia, 2023)[EMBARGOED UNTIL 5/1/2024] Due to the important roles the oral cavity plays in our daily lives ranging from eating and drinking to speech, diseases of the oral cavity significantly impact the quality of life. Oral cancers ... -
Pamp triggered responses as the first layer of immunity reprogramming cells for defense in both mammals and plants
(University of Missouri--Columbia, 2013)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Both mammals and plants live in a constant co-existence with a broad range of microbes. Some of these microbes have the potential to be pathogenic and ... -
Phage display peptides for breast cancer targeting
(University of Missouri--Columbia, 2010)Cancer cell surfaces differ from healthy cell surfaces allowing the detection of cancer targets on the cell. Use of these targets combined with radiolabeled targeting vehicles results in sensitive imaging agents, with ...