Shared more. Cited more. Safe forever.
    • advanced search
    • submit works
    • about
    • help
    • contact us
    • login
    View Item 
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate Studies - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2006 Dissertations (MU)
    • 2006 MU dissertations - Freely available online
    • View Item
    •   MOspace Home
    • University of Missouri-Columbia
    • Graduate Studies - Theses and Dissertations (MU)
    • Theses and Dissertations (MU)
    • Dissertations (MU)
    • 2006 Dissertations (MU)
    • 2006 MU dissertations - Freely available online
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.
    advanced searchsubmit worksabouthelpcontact us

    Browse

    All of MOspaceCommunities & CollectionsDate IssuedAuthorAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis SemesterThis CollectionDate IssuedAuthorAuthor/ContributorTitleSubjectIdentifierThesis DepartmentThesis AdvisorThesis Semester

    Statistics

    Most Popular ItemsStatistics by CountryMost Popular AuthorsStatistics by Referrer

    Statistical thermodynamics for RNA structures with simple tertiary contacts and pseudoknots

    Kopeikin, Zola, 1960-
    View/Open
    [PDF] public.pdf (7.788Kb)
    [PDF] short.pdf (7.185Kb)
    [PDF] research.pdf (1.129Mb)
    Date
    2006
    Format
    Thesis
    Metadata
    [+] Show full item record
    Abstract
    In this thesis, we develop statistical mechanical models for the folding of simple RNA tertiary structures. The focus is on the calculation of the tertiary structure conformational entropy. The key idea of the method is to account for the excluded volume correlations between different structural subunits by focusing on the interfacial regions. Tests against exhaustive computer lattice enumerations for chain conformations on a two-dimensional square lattice show that the model is accurate and reliable. The theory enables predictions for the free energy landscapes and conformational transitions for simple RNA tertiary folds and pseudoknots. Further applications to the force induced unfolding of RNA H-pseudoknots allow us to obtain the sequence-specific native structures, folding stabilities, pathways and folding cooperativities from the forcedependent free energy landscapes and the force-extension curves. Though the model is based on a two-dimensional lattice chain representation, the general principles developed in the model are directly applicable to the conformations at the atomic level.
    URI
    http://hdl.handle.net/10355/4360
    Degree
    Ph. D.
    Thesis Department
    Physics (MU)
    Collections
    • 2006 MU dissertations - Freely available online
    • Physics and Astronomy electronic theses and dissertations (MU)

    Send Feedback
    hosted by University of Missouri Library Systems
     

     


    Send Feedback
    hosted by University of Missouri Library Systems