Browsing Biological Sciences electronic theses and disserations (MU) by Thesis Semester "2019 Spring"
Now showing items 1-11 of 11
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Approaches for unveiling the kinetic mechanisms of voltage gated ion channels in neurons
(University of Missouri--Columbia, 2019)Ionic currents drive cellular function within all living cells to perform highly specific tasks. For excitable cells, such as muscle and neurons, voltage-gated ion channels have finely tuned kinetics that allow the ... -
Atypical localization of Eph-RTKs in childhood cancer rhabdomyosarcoma
(University of Missouri--Columbia, 2019)Rhabdomyosarcoma (RMS), the most common soft tissue tumor in children, is an aggressive cancer with a 5-year survival rate of 24% if it has metastasized. Current treatment options are limited to surgery, chemotherapy and ... -
Developing tools for making inferences from genomic data
(University of Missouri--Columbia, 2019)The central question that the King lab seeks to answer is, "What happens on the genomic level when phenotypes evolve?" To this end, the core focus of my work has been on developing software and analytical methods that ... -
Elucidation of the genetic control of carbohydrate partitioning in Zea mays
(University of Missouri--Columbia, 2019)Carbohydrate partitioning, the process of transporting carbohydrates from sites of synthesis in hotosynthetic tissue to developing sink tissues, is crucial for the growth, development, and yield in plants and crops. ... -
Exploring the diverse functions of peptidoglycan hydrolases in the plant pathogen, Agrobacterium tumefaciens
(University of Missouri--Columbia, 2019)The plant pathogen Agrobacterium tumefaciens displays an atypical form of unipolar elongation, followed by incipient pole synthesis during cell division and cell separation. Currently, how polar growing bacteria modulate ... -
From unique killers to a jumbo genome - isolation and characterization of phages that infect the plant pathogen, Agrobacterium tumefaciens
(University of Missouri--Columbia, 2019)Bacteriophages and their lytic peptides can protect plants from phytopathogens such as Agrobacterium tumefaciens. To better understand mechanisms of phagemediated host killing, we isolated and characterized five lytic ... -
Impact of selective motor neuron death on hypoglossal motor neuron survival and tongue morphology in a novel model of dysphagia
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by the progressive loss of motor neurons and paralysis of the muscles they ... -
Metabolic responses of meniscal tissue to collagenase stimulation
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Meniscal degeneration as a result of injury or aging is a common contributing factor in the development of knee OA. Meniscal degeneration develops and ... -
The molecular underpinnings of neuronal cell identity in the stomatogastric ganglion of cancer borealis
(University of Missouri--Columbia, 2019)Throughout the life of an organism, the nervous system must be able to balance changing in response to environmental stimuli with the need to produce reliable, repeatable activity patterns to create stereotyped behaviors. ... -
Novel approach to assessment of efficacy of platelet inhibition by clopidogrel and aspirin in healthy dogs
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI--COLUMBIA AT REQUEST OF AUTHOR.] Introduction: Antiplatelet therapy, including clopidogrel and aspirin, is used to decrease the risk of thromboembolism in dogs. However, ... -
Regional mapping of the osteoarthritic joint
(University of Missouri--Columbia, 2019)[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Osteoarthritis (OA) progresses from a focal lesion of articular cartilage to whole-joint inflammation and degradation. The "focal spread" progresses ...