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Novel protective modifiers in mouse models of spinal muscular atrophy
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal Muscular Atrophy (SMA) is a neuromuscular disease caused by the homozygous deletion or mutation in the survival motor neuron-1 (SMN1) gene ...
Vaccine-induced protective immunity against coxiella burnetii
(University of Missouri--Columbia, 2019)
Coxiella burnetii is an obligate intracellular Gram-negative bacterial pathogen and the causative agent of human Q fever. This disease presents acutely as a flu-like illness, although it can escalate to a chronic and often ...
Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)
Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ...
Mechanisms of clostridial neurotoxin binding and entry
(University of Missouri--Columbia, 2016)
The botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) make up the clostridial neurotoxin (CNT) family. The CNTs are produced by Clostridium botulinum and Clostridum tetani respectively, and are the most potent ...
The role of sphingosine kinase in influenza virus mediated inflammasome activitation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Influenza viruses continue to pose a grave burden on the global health and economy. Dysregulated innate immune system can lead to rapid infiltration ...
Yersinia pestis YopK contributes to immune evasion and cell death to promote plague
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] YopK is a 21-kilodalton protein that is secreted and translocated by the type three secretion system of Yersinia pestis, the causative agent of pneumonic, ...
First contact :potential consequences of exposure of macrophage-like cells to divergent bacteria
(University of Missouri--Columbia, 2013)
The innate immune system must react to a wide variety of foreign stimuli, only a relatively small proportion of which may be classified as harmful. The goal of this thesis was to investigate interactions between macrophages ...
Mechanistic inhibition studies of SARS-CoV replication and entry
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Severe acute respiratory syndrome (SARS) is an infectious and highly contagious disease that is caused by SARS-associated coronavirus, (SARS-CoV) and ...
Viral envelope proteins and the HIV-1 accessory gene Vpu mediate selectivity of viral and host proteins in retroviral assembly
(University of Missouri--Columbia, 2012)
Retroviruses are enveloped RNA viruses that assembly primarily at the plasma membrane of the host cell. During budding from the membrane, they acquire their own glycoproteins as well as a lipid bilayer derived from the ...
Definition of VPU sensitivity using a model VPU target and role of hydrophobicity of the membrane spanning domain in the viral envelope glycoprotein fusogenicity
(University of Missouri--Columbia, 2013)
Retroviral compatibility with diverse glycoproteins has been known and identified through the course of several studies. However, molecular mechanisms of glycoprotein acquisition are poorly defined. Glycoproteins are ...
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ...
Characterization of the non-structural proteins of adeno-associated virus (AAV) and minute virus of canine (MVC)
(University of Missouri--Columbia, 2012)
Parvoviruses are among the smallest of the animal DNA viruses. Due to their compact genome, these viruses display immense heterogeneity both in the mechanisms involved in gene expression and the functions of the encoded ...
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T ...
Within and beyond immunomodulatory strategies against autoimmune diabetes : antigen-specific tolerance and endothelial regeneration
(University of Missouri--Columbia, 2013)
Type 1 diabetes (T1D) is a chronic disorder in which the cells of the immune system mediate selective destruction of the insulin-producing [beta]-cells in the islets of Langerhans in the pancreas. CD4+ effector T cells, ...
Mechanisms of inhibition and resistance to antiviral drugs targeting human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV)
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Although human immunodeficiency virus type 1 (HIV-1) and hepatitis B virus (HBV) are very different viruses, the replication of their genome involves ...
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ...
Dendritic cells, IL-12Rbeta2, and IL-13Ralpha1 signaling: the battle for control of neonatal immunity
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Newborns are highly susceptible to microbial infections and allergic reactions. This susceptibility is due to a lack of Th1 cells and an excess of Th2 ...
Factors contributing to humoral immunity against pneumonic plague
(University of Missouri--Columbia, 2012)
Yersinia pestis is the etiologic agent of plague and is responsible for more human deaths throughout history than any other bacterial pathogen. During infection bacteria inject effector proteins into target host cells using ...
The cellular immune response to murine lyme borreliosis
(University of Missouri--Columbia, 2015)
Lyme disease is caused by the bacterial spirochete Borrelia burgdorferi. There are approximately 300,000 new cases of Lyme Disease reported in the United States each year. Individuals with Lyme disease often suffer from ...
Role of T cell receptor signaling in CD8 T cell memory
(University of Missouri--Columbia, 2015)
The generation of immunological memory is the basis for vaccination. The development of memory CD8 T cells is required for long-term protection against intracellular pathogens, such as viruses, and tumors. While the ...