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Development of gene therapy for Duchenne muscular dystrophy heart disease in the MDX mouse model
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a fatal genetic muscle disease with no cure. DMD results from mutations in a critical muscle protein called ...
Exploring the cell surface : identification and characterization of lipoproteins in Mycoplasma mycoides subsp. mycoides large colony, Mycoplasma mycoides subsp. capri, and Mycoplasma capricolum subsp. capricolum
(University of Missouri--Columbia, 2009)
The Mycoplasma mycoides cluster is a group of genetically and antigenically related pathogenic bacteria that infect ruminants. The M. mycoides cluster members that are the focus of this discussion are three caprine pathogens: ...
Regulation of Pcl6 and Pcl7 in a Glc7 pathway in Saccharomyces cerevisiae
(University of Missouri--Columbia, 2010)
GLC7 is an essential gene in Saccharomyces cerevisiae that encodes the catalytic subunit of protein phosphatase-1. Glc7 is conditionally activated by phospho-Glc8, which is phosphorylated by the cyclin dependent kinase, ...
Hormonal and genetic regulation of Helicobacter hepaticus-induced intestinal inflammation
(University of Missouri--Columbia, 2010)
Inflammatory Bowel Diseases (IBDs) affect millions of people worldwide and are characterized by a chronic intestinal inflammation resulting from a dysregulated immune response to environmental stimuli in genetically ...
Insights into understanding malaria parasite biology : characterization of the Plasmodium protein, MAL13P1.319
(University of Missouri--Columbia, 2011)
Malaria is responsible for approximately 250 million human infections and about a million deaths annually and is caused by the protozoan parasite Plasmodium, with P. falciparum the most pathogenic form of human malaria. ...
Investigating the role of germline RNA helicase-1 in Caenorhabditis elegans
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The germline specific RNA helicase GLH-1, a constitutive P-granule component, and DCR-1, the riboendonuclease responsible for processing small RNAs ...
Mechanisms of central and peripheral immune tolerance
(University of Missouri--Columbia, 2011)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The decision of a stem cell to develop into the myeloid or lymphoid lineage has been postulated to occur in the bone marrow. However, a marker of ...
Identification and characterization of Boone Cardiovirus, a novel virus of laboratory rats
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Cardioviruses are members of the Picornaviridae family capable of causing several forms of disease including myocarditis, encephalitis, diabetes, fetal ...
On the role of cytokines and route of antigen delivery on the modulation of experimental autoimmune encephalomyelitis
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Experimental autoimmune encephalomyelitis (EAE) is a mouse model of the human autoimmune disease multiple sclerosis and is caused by myelin-reactive T ...
Sequence and secondary structural analysis of a novel class of RNA aptamers that inhibit reverse transcriptase
(University of Missouri--Columbia, 2012)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] RNA aptamers are synthetic RNAs selected for their ability to bind a molecular target. Reverse Transcriptase (RT) is the major target of antiretroviral ...
Contribution of the immune system and astrocytes to spinal muscular atrophy pathology
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease and the leading genetic cause of infant mortality. SMA is caused by ...
Protection from pneumonic plague by the induction of heme oxygenase-1
(University of Missouri--Columbia, 2018)
Yersinia pestis is the etiological agent of the disease known as plague. The pathology of this disease is characterized by organ failure due to necrosis and hyperinflammation towards the end of the disease. However, Y. ...
The role of apoptosis during inflammation resolution in Lyme arthritis
(University of Missouri--Columbia, 2019)
Experimental Lyme arthritis is induced by the infection of C3H mice with the spirochete, Borrelia burgdorferi, and is a valuable model to study the regulation of inflammation during bacterial infection. While the lab has ...
Structural inferences for reverse transcribing viruses and drug resistance
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] As we narrowly focus on the fundamental questions of our respective systems it is important to interact with the broader scientific community to gain ...
Reparative dysfunction during muscle regeneration in Duchenne muscular dystrophy: therapeutic approaches to modulating the muscle environment and muscle stem cells
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Duchenne muscular dystrophy (DMD) is a lethal muscular dystrophy resulting from functional loss of the dystrophin protein, a critical sub-sarcolemmal ...
The role of sphingosine 1-phosphatemetabolizing enzymes in host defense to RNA virus infections
(University of Missouri--Columbia, 2016)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Viruses are intracellular parasites that rely on the host cell machinery to effectively replicate themselves and spread within the host to cause ...
Interferon regulatory factor 1 (IRF-1) directs IL-4/IL-13 induced death of neonatal Th1 cells
(University of Missouri--Columbia, 2017)
Newborns typically have immune responses that are allergic, due to a predominance of Th2 cells, and lack the ability to respond to vaccines as well as display poor protection against microbes, due to a lack of Th1 cells. ...
Analysis of factors that affect pseudotyping in retroviruses
(University of Missouri--Columbia, 2019)
Retroviral vectors can efficiently pseudotype with various envelope glycoproteins; however, the molecular mechanism of glycoprotein acquisition process is not completely understood even with their native Env proteins. ...
Labeling HIV-1 nucleic acids during infection and effect of MOV10 in HBV replication
(University of Missouri--Columbia, 2018)
Technical limitations in simultaneous microscopic visualization of RNA, DNA, and proteins of HIV have curtailed progress in this field. To address this need we have developed a microscopy approach, multiplex immunofluorescent ...
Regeneration of insulin-producing [beta]-cells during recovery from disease: a cure for Type 1 Diabetes
(University of Missouri--Columbia, 2018)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Type 1 diabetes (T1D) is a chronic disease condition characterized by destruction of the insulin-producing [beta]-cells by self-reactive lymphocytes ...