Priority Updates to Research Literature (PURLs)
Priority Updates from the Research Literature (PURLs) distill the literature to those few articles that are relevant, practice-changing, and able to be implemented immediately. They generate new evidence-based recommendations for practice for family physicians and other primary care clinicians. PURLs are published exclusively in the Journal of Family Practice.
Items in MOspace are protected by copyright, with all rights reserved, unless otherwise indicated.
Recent Submissions
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Which anticoagulant is safest for frail elderly patients with nonvalvular A-fib?
(Family Physicians Inquiries Network, 2022-11)Consider apixaban, which demonstrated a lower adverse event (AE) rate than warfarin regardless of frailty status, for anticoagulation treatment of older patients with nonvalvular atrial fibrillation (AF); by comparison, ... -
What BP target is appropriate for pregnant patients with mild chronic hypertension?
(Family Physicians Inquiries Network, 2023-01)Treat mild chronic hypertension during pregnancy to a target of [greater than] 140/90 mm Hg to reduce the risk for adverse pregnancy outcomes. -
Put down the electronics after a concussion?
(Family Physicians Inquiries Network, 2023-01)Advise your teenaged and young adult patients with concussion to avoid electronic screens in the first 48 hours after a concussion to minimize time to symptom resolution. -
Is self-administered DMPA an answer to contraception access in the post-Roe era?
(Family Physicians Inquiries Network, 2023-03)Consider prescribing self-administered subcutaneous depot medroxyprogesterone acetate (DMPA) for contraception instead of provider-administered DMPA. Self-administration improves contraception continuation rates without ... -
Is combination pharmacotherapy effective for patients with acute depression?
(Family Physicians Inquiries Network, 2023-04)Use a combination of a presynaptic α2-autoreceptor antagonist (eg, mirtazapine or trazodone) and a monoamine reuptake inhibitor (eg, selective serotonin reuptake inhibitor [SSRI], serotonin-norepinephrine reuptake inhibitor ... -
Consider this tool to reduce antibiotic-associated adverse events in patients with sepsis
(Family Physicians Inquiries Network, 2023-01)For patients hospitalized with sepsis, consider procalcitonin (PCT)-guided early discontinuation of antibiotic therapy for fewer infection-associated adverse events (AEs). -
Consider this SGLT2 inhibitor for patients with HF with preserved ejection fraction
(Family Physicians Inquiries Network, 2022-12)Consider adding empagliflozin 10 mg to usual therapy to reduce hospitalization of symptomatic patients with heart failure with preserved ejection fraction (HFpEF; EF > 40%) and an N-terminal pro–B-type natriuretic peptide ... -
Noncardiac inpatient has acute hypertension: Treat or not?
(Family Physicians Inquiries Network, 2022-09)A retrospective study found more harm than benefit from treating elevated blood pressure in hospitalized noncardiac patients. -
A "no-biopsy" approach to diagnosing celiac disease
(Family Physicians Inquiries Network, 2022-10)This noninvasive alternative to the diagnostic gold standard may cut risk and expense for adult patients. -
Time to consider topical capsaicin for acute trauma pain?
(Family Physicians Inquiries Network, 2022)Topical capsaicin is more effective than topical piroxicam at reducing pain in acute upper extremity injuries. -
Migraine relief in 20 minutes using eyedrops?
(Family Physicians Inquiries Network, 2022)One randomized crossover trial demonstrated the effectiveness of this simple, affordable treatment for patients with acute migraine pain. -
Is it time to approach spontaneous pneumothorax more conservatively?
(Family Physicians Inquiries Network, 2022)A recent study provides modest evidence for observational management over interventional treatment, sparing patients from invasive procedures. -
Getting a jump on recovery from sports-related concussion
(Family Physicians Inquiries Network, 2022)Early subthreshold aerobic exercise safely improved recovery time over a stretching regimen among adolescents in this clinical trial. -
Colchicine may decrease cardiovascular events in patients with coronary artery disease
(Family Physicians Inquiries Network, 2022)This oral anti-inflammatory agent may offer a low-cost option for prevention of cardiovascular events in this patient population. -
Can extended anticoagulation prophylaxis after discharge prevent thromboembolism?
(Family Physicians Inquiries Network, 2022)A meta-analysis confirmed the benefit of thromboprophylaxis with a direct oral anticoagulant for high-risk nonsurgical patients after hospital discharge. -
Can early introduction of gluten reduce risk of celiac disease?
(Family Physicians Inquiries Network, 2022)This UK study revealed the benefits of introducing gluten at age 4 months. -
Alcohol abstinence reduces A-fib burden in drinkers
(Family Physicians Inquiries Network, 2022)A recent Australian study demonstrated a significant reduction in A-fib recurrence and burden among regular drinkers who abstained from alcohol. -
Monotherapy for nonvalvular A-fib with stable CAD?
(Family Physicians Inquiries Network, 2021)A meta-analysis found oral anticoagulant (OAC) monotherapy provided efficacy comparable to OAC plus single antiplatelet therapy--with lower bleeding risk. -
Skip that repeat DXA scan in these postmenopausal women
(Family Physicians Inquiries Network, 2021)Skip that repeat DXA scan in these postmenopausal women. Repeat bone density measurement offers no advantage in predicting fracture risk in postmenopausal women who do not have osteoporosis. PRACTICE CHANGER: Do not routinely ... -
Validated scoring system identifies low-risk syncope patients
(Family Physicians Inquiries Network, 2021)This study validated the Canadian Syncope Risk Score for predicting 30-day serious outcomes in patients presenting to the ED within 24 hours of syncope.