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Now showing items 41-60 of 72
pH sensitive fluorescent sensors
(University of Missouri--Columbia, 2007)
Pheochromocytoma is a cancer of the adrenal gland. Pheochromoocytomas produce a variety of catecholamines, including norepinephrine. The result is high blood pressure which is caused by the release of catecholamines into ...
Evaluating the suitability of the human toenail as a biomonitor for manganese status: the one source cohort
(University of Missouri--Columbia, 2007)
Numerous studies have demonstrated that the human toenail is a reliable biomonitor for the intake of Se and other elements. The objective of this study was to evaluate the hypothesis that Mn intake is reflected in toenail ...
Ligands for the sigma receptor and the mu-opioid receptor
(University of Missouri--Columbia, 2007)
The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and ...
Ammonia elimination from protonated nucleobases
(University of Missouri--Columbia, 2007)
The dediazoniations of the diazonium ion 1 of 4-aminopyrimidine and of the tautomeric cytosinediazonium ions 2 and 3 are facile and result in the formations of cations 4, 5, and 6. The pyrimidine ring-opening of 4, 5 and ...
Spatially resolved and bulk zinc analysis in biological samples of patients at different stages of Alzheimer's disease by high resolution inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2008)
One hypothesis that has gained considerable attention in the pathogenesis of Alzheimer's disease (AD) is trace element toxicity, and various elements, including zinc, have become the foci of renewed interest. The first ...
Separation and identification of peptides by integrated multidimensional liquid chromatography-mass spectrometry (IMDLC-MS)
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Integrated multidimensional liquid chromatography (IMDLC) is an innovative method used for separation of tryptic peptides. In this method a two-component ...
High valent uranium dioxo and imido complexes : synthesis and structure
(University of Missouri--Columbia, 2008)
Early actinide elements have attracted considerable attention in recent years due to the need for rigorous advancements in spent nuclear fuel recycling and remediation technologies, and for their emerging versatility in ...
Copper (I) coordination networks synthesized with solid-solid reactions
(University of Missouri--Columbia, 2008)
The use of solid-solid reactions in the development of one-, two-, and three dimensional Cu(I) coordination networks are discussed. The solid-solid reactions were monitored by a variety of instrumental techniques to achieve ...
Chemical mechanisms underlying the medicinal activity of metabolically-activated N-oxide antitumor agents
(University of Missouri--Columbia, 2008)
Tirapazamine (TPZ) belongs to a new class of bio-reductively activated hypoxiaselective anti-cancer agents and is currently undergoing in various clinical trials including Phase I, II and III. Anti-cancer activity of TPZ ...
Spectroscopic investigations of the beta-amyloid peptide
(University of Missouri--Columbia, 2008)
The focus of this project is two-fold: examining the native structures of three different fragments of the beta-amyloid (A[beta]) peptide, and attempting to overcome some of the difficulties encountered in such an examination. ...
Spectroscopic investigations of acrylodan dye interactions with poly(amidoamine) and poly(propyleneimine) dendrimers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The novel molecular architecture of dendrimers facilitates use in many applications. Using the solvatochromic probe phenol blue, the first direct ...
Oxidation & 1, 5-hydride shift of sulfoximine derivatives
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Oxidation of N-alkyl and N-aryl sulfoximines and 1,5-hydride shift of S-alkenyl sulfoximines have been studied. Oxidation of N-alkyl sulfoximines using ...
Spectroscopic investigations of dendritic polymers as molecular containers
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Previous research has shown the fluorescent probe phenol blue will associate with the dendritic polymers polypropyleneimine (PPI) and polyamidoamine ...
Comparison of hyperbranched and dendritic polymers with fluorescent reporter molecules
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Hyperbranched polymers containing a core region are a relatively new class of polymers with many similarities to dendrimers, including their proposed ...
Synthesis and structure-activity relationship of a series of sigma receptor ligands
(University of Missouri--Columbia, 2007)
Sigma receptors are involved in several biological processes, and sigma ligands might be promising as cancer treatment agents, cocaine abuse medicines, and valuable psychiatric drugs. In an attempt to elucidate effectual ...
Sixteen valence-electron species containing boron: structural diversity abounds
(University of Missouri--Columbia, 2005)
[B, C, F, H₂] and [B, N, O, H₂] have been investigated via high level ab initio calculations. Both cyclic and acyclic connectivities have been examined for the singlet state. Chemical intuition suggests a ketene-like ...
Determination of total selenium and seleno-amino acids in yeast and aquatic organisms by liquid chromatography and inductively coupled plasma mass spectrometry
(University of Missouri--Columbia, 2007)
The primary goal of this dissertation research was to develop methods for routine speciation analysis of selenium in tissues. A method for total selenium using on-line stable isotope dilution analysis with conventional ...
Molecular dynamics simulations of pressure shocks in liquid phase nitromethane
(University of Missouri--Columbia, 2007)
The dynamic energy transfer processes present in liquid nitromethane (NM) under pressure shock loading conditions have been investigated by nonequilibrium molecular dynamics methods using a previously developed, fully ...
Investigation of the replacement of cysteine residues in DOTA-(Tyr³)-octreotate: synthesis, characterization and evaluation of biological activities
(University of Missouri--Columbia, 2006)
Modification of the peptide sequence of DOTA-Tyr³-octreotate is carried out by substituting the cysteine moieties with D-Cysteine, L-Penicillamine and D-Penicillamine in one or both positions to study the effect of this ...
Deantiaromatization as a driving force in an electrocyclization of cyclopentadienone and the total synthesis of 1-epi-esco-pseudopteroxazole
(University of Missouri--Columbia, 2007)
Deantiaromatization has been successfully demonstrated as a driving force in an electrocyclization of cyclopentadienones. The reaction was found to be general for a number of substrates and provides a unique way to access ...