dc.contributor.author | Madigosky, Wendy S. | eng |
dc.contributor.author | Meadows, Susan E. | eng |
dc.date.issued | 2004 | eng |
dc.description.abstract | When herpes simplex virus (HSV) type 1 lesions are in the papule or vesicle stage, there is no benefit to starting oral acyclovir (strength of recommendation [SOR]: C, based on expert opinion). However, topical acyclovir 5% cream applied 5 times a day decreases pain and the duration of hard crust (SOR: B, extrapolated from randomized controlled trials [RCTs]). If started at the onset of symptoms (during the prodrome stage), acyclovir (400 mg 5 times daily for 5 days) decreases pain and healing time to loss of crust and valacyclovir (2 g twice daily for 1 day) reduces the lesion duration and time to healing and may prevent lesion development (SOR: A, based on RCTs). | eng |
dc.identifier.uri | http://hdl.handle.net/10355/3042 | eng |
dc.language | English | eng |
dc.publisher | Family Physicians Inquiries Network | eng |
dc.relation.ispartofcollection | Clinical Inquiries, 2004 (MU) | eng |
dc.relation.ispartofcommunity | University of Missouri-Columbia. School of Medicine. Department of Family and Community Medicine. Family Physicians Inquiries Network | eng |
dc.relation.ispartofseries | Journal of family practice, 53, no. 11 (November 2004): 923-924. | eng |
dc.rights | OpenAccess. | eng |
dc.rights.license | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 License. | eng |
dc.subject | herpes labialis | eng |
dc.subject | prodrome stage | eng |
dc.subject | pain relief | eng |
dc.subject | lesion duration | eng |
dc.subject.lcsh | Herpes Simplex Virus | eng |
dc.subject.lcsh | Acyclovir | eng |
dc.subject.lcsh | Herpesvirus diseases | eng |
dc.title | Does acyclovir help herpes simplex virus cold sores if treatment is delayed? | eng |
dc.type | Article | eng |