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Phenotypic modulation of vascular smooth muscle cells : evidence for a role of the G protein-coupled P2y2 receptor
(University of Missouri--Columbia, 2008)
G protein-coupled receptors regulate two major functions of vascular smooth muscle cells (SMCs) - the vasomotor contractile response and the proliferative response. The contractile phenotype of SMCs has mainly been studied ...
A study of SecA : the motor of the bacterial secretion system by site-directed spin labeling and EPR
(University of Missouri--Columbia, 2008)
For more than 3 decades, the biochemical details of the Sec system of protein export have been teased out of Escherichia coli. Through these efforts we know that SecA, the ATPase of the Sec system, interacts with several ...
Substrate activation in the urate oxidase reaction
(University of Missouri--Columbia, 2008)
The enzyme urate oxidase (UO) is involved in nitrogen metabolism of many organisms. Urate oxidation is carried out by UO without the aid of a metal ion or cofactor. A catalytic diad has previously been proposed to be ...
Signals affecting the urease status of plant-associated bacteria, Methylobacterium spp
(University of Missouri--Columbia, 2007)
Pink-Pigmented Facultative Methylotrophic bacteria (PPFMs, Methylobacterium spp.) have been found to be the most abundant microorganisms among phylloplane microflora, and have been recovered from all plants examined. I ...
The minimal primary structures of RNA aptamers selected to bind HIV-1 reverse transcriptase
(University of Missouri--Columbia, 2010)
Human Immunodeficiency Virus (HIV) reverse transcriptase (RT) is the most common molecular target of current HIV treatments. Oligonucleotide aptamers bind and inhibit the RNA- and DNA-dependent polymerization activities ...
Characterization and functional significance of Msc2p & Zrg17p, which form a zinc transport complex in the endoplasmic reticulum of Saccharomyces cerevisiae
(University of Missouri--Columbia, 2004)
We demonstrate a novel interaction between two members of the cation diffusion facilitator (CDF) family in Saccharomyces cerevisiae: Msc2p and a newly recognized CDF family member, Zrg17p. Both Msc2p and Zrg17p have been ...
Identification of novel breast carcinoma and melanoma avid peptides for imaging
(University of Missouri--Columbia, 2009)
During the last decade, peptides and their derivatives have been employed as effective cancer imaging agents. We aimed to identify new peptides probes specific for melanoma and breast carcinoma by phage display technology. ...
The role of the P2Y₂ nucleotide receptor in inflammation: the mechanisms of P2Y₂ receptor-mediated activation of G proteins
(University of Missouri--Columbia, 2007)
The extracellular ATP/UTP receptor, i.e., the P2Y₂ receptor (P2Y₂R), mediates pro-inflammatory responses in the vasculature, including the endothelium-dependent infiltration of monocytes and their transmigration into sites ...
Discovery of epitopes governing MMP-12 specificity for fibrillar substrates : BINDSIght, a method for determining specific sites of substrate surface interactions
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] What determines MMP-12 elastase activity? We have found that the fibrillar substrate specificity of MMP-12 involves surfaces ranging beyond the ...
Structure and conformational signaling in the escherichia coli aspartate receptor tar
(University of Missouri--Columbia, 2014)
Characterization of PGAM5
(University of Missouri--Columbia, 2013)
Programmed cell death (PCD) is a naturally occurring event that is highly regulated and required for normal development. The protein phosphoglycerate mutase 5 (PGAM5) has been implicated in apoptosis, necrosis, and autophagy ...
Neuroprotective roles of the P2Y[subscript 2] nucleotide receptor
(University of Missouri--Columbia, 2014)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Alzheimer's disease (AD) is the most prevalent neurodegenerative disease. AD is an important disease to study because of the high cost of care for ...
Plant protein lysine acetylation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Amongst the hundreds of known protein posttranslational modifications, lysine acetylation is noteworthy for its widespread distribution, and for having ...
Elucidating the roles of the ATP7A copper transporter in cultured cells, tumor growth and metastasis
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is an essential trace metal in all organisms. In humans, copper plays structural and catalytic roles for numerous enzymes and is required for ...
Mechanisms of salivary gland cell proliferation in vitro by P2Y2R activation
(University of Missouri--Columbia, 2012)
Sjögren's syndrome (SS) and the side-effects of γ-radiation therapies for head and neck cancers cause salivary gland dysfunction. Salivary gland regeneration has been considered to be a very promising approach for restoring ...
Comparison of standard treatments of breast cancer with new experimental treatments targeting caveolin-1
(University of Missouri--Columbia, 2013)
Breast cancer is a complex disease at both an anatomical and molecular levels. The complexity of the disease is a source of difficulty in identifying and treating the cancer, since varying subtypes of cancer respond ...
The role of Rex in regulation of sulfate reduction in Desulfovibrio vulgaris Hildenborough
(University of Missouri--Columbia, 2014)
Although the enzymes for dissimilatory sulfate reduction by microbes have been studied, the mechanism for transcriptional regulation of the encoding genes remain unknown. In the work presented here, the model sulfate-reducing ...
Characterization of the 14-3-3 client protein interactome from developing arabidopsis seed and regulation by protein phosphorylation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Understanding the regulatory mechanisms controlling reserve deposition during seed development is an academic endeavor with the potential for socioeconomic ...
The copper ATPases : intracellular trafficking and nervous system function
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Copper is essential for life, as it participates as a cofactor in numerous enzymatic reactions including energy generation, antioxidant defense, ...
[alpha]A-crystallin derived peptide, [alpha]A66-80 induced aggregation and precipitation of soluble [alpha]-crystallin : a contribution to age-related cataract formation
(University of Missouri--Columbia, 2013)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Age-related cataract is the result of aggregation of lens proteins, crystallins. The formation of aggregates in the aging lens has been shown to correlate ...