Search
Now showing items 1-20 of 111
Inhibition of progestin-induced VEGF in mammary cancer by curcumin and 2-methoxy estradiol and their potential role as anti-angiogenic & chemopreventive compounds
(University of Missouri--Columbia, 2009)
Estrogen/Progestin combined hormone replacement therapy (HRT) is commonly prescribed to alleviate the symptoms of menopause in women. Combination HRT however is associated with an increased risk of breast cancer, an effect ...
Estradiol regulates multiple tetrodotoxin-sensitive sodium currents in gonadotropin releasing hormone neurons: implications for cellular regulation of reproduction
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The gonadotropin releasing hormone (GnRH) neuron is the pivotal control center in a tightly regulated reproductive axis. Estradiol typically has a ...
Fgf2-stimulated proliferation is lower in muscle precursor cells from old rats
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] In aged skeletal muscle, impairments in the regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs), ...
Characterization of the alignment of the canine pelvic limb
(University of Missouri--Columbia, 2009)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Angular limb deformities are common place in the canine. Until recently, repair of deformities was based upon crude radiographic measures of bone ...
Gold nanoparticle-biomolecule conjugates : synthesis, properties, cellular interactions and cytotoxicity studies
(University of Missouri--Columbia, 2008)
This research focuses on conjugation of two major biomolecules i.e., Bombesin and Annexin V, to AuNps and studying their target specificity. The target specificity of AuNps coated with Bombesin, a GRP receptor specific ...
The antiendotoxin effects of polymyxin B in a feline model of endotoxemia
(University of Missouri--Columbia, 2010)
Introduction: Directed, effective therapies for feline sepsis are needed to reduce the high morbidity and mortality associated with this disease. Materials and Methods: We investigated the anti-endotoxin effects of PMB in ...
The cystic fibrosis transmembrane conductance regulator and acid-base transporters of the murine duodenum
(University of Missouri--Columbia, 2006)
The alkaline mucus barrier of the duodenum plays an important role in protecting the epithelium from acidic chyme entering from the stomach. Active HCO₃⁻ secretion involves the apical membrane activities of the cystic ...
Sensory integration during blood loss in conscious rabbits
(University of Missouri--Columbia, 2006)
Central nervous system integration of sensory inputs is critical for orchestrating physiological responses to stress. The focus of my doctoral research was investigating the physiological consequences of sensory stimulation ...
Characterization of the humoral immune response to a commercial staphylococcus aureus mastitis vaccine
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] The objective of this thesis was to test the hypothesis that a commercial vaccine for bovine S. aureus mastitis fails to induce a humoral immune response ...
In vitro evaluation of veterinary and human suture anchors in metaphyseal bone of the canine tibia
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Suture anchors, also called bone or tissue anchors, provide orthopedic surgeons a mechanism for secure fixation of soft tissues to bone. A human system ...
Role of the intermediate-conductance Ca²⁺-activated K⁺ channel (K[ca]3.1) in coronary smooth muscle cell phenotypic modulation
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Smooth muscle cell phenotypic modulation is characterized by suppression of smooth muscle specific marker gene expression, migration, and proliferation ...
Modulation of the ACTH response to stress by IL-6, nitric oxide, diet and exercise
(University of Missouri--Columbia, 2006)
The release of ACTH from the anterior pituitary is one step in the activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is activated in response to stress and the secretion of ACTH is under the control ...
The effect of free fatty acids on endothelial cells
(University of Missouri--Columbia, 2005)
The purpose of this thesis was to determine if specific components of oxidized low density lipoprotein (OxLDL) molecules e.g. oxidized polyunsaturated fatty acids (PUFAs), or saturated free fatty acids (FFA) are alone ...
A missense mutation in Atf2 in standard poodles with fatal neonatal encephalopathy
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Neonatal encephalopathy with seizures (NEWS) is a previously undescribed autosomal recessive disease in Standard Poodles. Affected puppies are small ...
Mechanisms regulating skeletal muscle satellite cell cycle progression
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Skeletal muscle fibers are multinucleated with each myonucleus capable of governing a finite cytoplasmic volume. In healthy skeletal muscle, myonuclear ...
Sympathetic control of the collateral circulation : effects of time post-occlusion and exercise training
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] These studies evaluated the role of alpha-adrenergic receptors ([alpha]AR) and NPYergic receptors in the collateral circulation following acute and ...
Post-angioplasty restenosis : the effects of exercise training
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Percutaneous transluminal coronary angioplasty (PTCA) stimulates vascular cell proliferation and migration resulting in restenosis of the revascularized ...
Estrogen receptor [alpha] and [beta] knock-out effects on skeletal muscle in mature female and male mice, and aromatase knock-out effects on skeletal muscle in mature male mice
(University of Missouri--Columbia, 2007)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT AUTHOR'S REQUEST.] Estrogen regulates skeletal muscle mass and function in female. Estrogen may influence skeletal muscle mass and function during development in males ...
Immunomodulatory effects of opioids
(University of Missouri--Columbia, 2010)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Opioids have been shown to modulate the immune system in animal models by affecting both the acquired and innate arms of the immune system. Many of ...
Comprehensive characterization of canine meniscal pathology
(University of Missouri--Columbia, 2010)
Meniscal injury is one of the most common causes of pain and dysfunction in the human knee and canine stifle joint. In the canine patient, meniscal injury is usually secondary to cranial cruciate ligament rupture, and the ...