Search
Now showing items 101-112 of 112
The effect of gene therapy on the pathogenesis of amyotrophic lateral sclerosis (ALS)
(University of Missouri--Columbia, 2021)
Amyotrophic lateral sclerosis (ALS) is a devastating progressive and neurodegenerative disease. In early stages of ALS, there are known pathological changes in the structure of neuromuscular junctions (NMJ); however, all ...
The molecules that move us : evaluating potential genetic and molecular determinants of physical activity motivation
(University of Missouri--Columbia, 2019)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Physical activity is at the basis of human history. The fact that we occupy every continent, were built for long distance travel, and that we find ...
Prospective evaluation of the fecal microbiome in dogs with large-cell lymphoma receiving chop chemotherapy
(University of Missouri--Columbia, 2021)
The fecal microbiome composition has been associated with reduced efficacy of cancer therapy and adverse side effects in humans, and chemotherapy has been shown to alter the gut microbiome. The relationship between microbiota ...
Prolonged survival in 58 dogs with thyroid carcinoma treated with radioactive iodine as sole therapy
(University of Missouri--Columbia, 2023)
Treatment of thyroid carcinomas in people and dogs often involves multimodal therapy, including radioactive iodine (I-131). The objective of this study is to describe outcomes associated with I-131 as sole therapy in dogs ...
Cardiac biomarkers (NT-proBNP and cardiac troponin-I) and point-of-care ultrasound in dogs with cardiac and non-cardiac causes of non-hemorrhagic ascites
(University of Missouri--Columbia, 2023)
Background: Non-hemorrhagic ascites (NHA) can be caused by cardiac diseases (cNHA) and non-cardiac diseases (ncNHA). N-terminal brain natriuretic peptide (NT-proBNP), cardiac troponin-I (cTnI) and point-of-care ultrasound ...
The role of creatine supplementation and mTORC1 signaling in ameliorating cognitive deficiency in a neuroinflammatory rat model
(University of Missouri--Columbia, 2022)
Mild cognitive impairment (MCI) was defined as a boundary area between cognitive function of natural aging and dementia. Early studies have suggested that MCI could be a therapeutic window for prevention of dementia, given ...
Phase I clinical trial evaluating calcium electroporation for management of cutaneous tumors in dogs
(University of Missouri--Columbia, 2023)
Traditionally, cutaneous tumors in dogs are managed with surgery, and adjuvant radiation therapy is considered in cases where complete resection is not achieved. Electrochemotherapy (ECT), with both cisplatin and bleomycin, ...
Artificial neural network models utilize chamber-specific predictors of cardiac fibrosis in ovariectomized and aortic-banded Yucatan mini-swine
(University of Missouri--Columbia, 2022)
Objective: Heart failure with preserved ejection fraction (HFpEF) is a disease associated with significant clinical pathophysiological heterogeneity in which maladaptive cardiac fibrosis, in both the right and left ventricles ...
Evaluation of a relatively hyperosmolar irrigation solution for use in equine femorotibial arthroscopy
(University of Missouri--Columbia, 2022)
Hyperosmolar irrigation solutions have been shown to decrease fluid extravasation during arthroscopic procedures and safety has been demonstrated in canine and human studies. Prospective, blinded, randomized controlled ...
A projection from the hypothalamic paraventricular nucleus to the nucleus tractus solitarii is critical for cardiorespiratory responses to hypoxia
(University of Missouri--Columbia, 2019)
The arterial chemoreflex is an essential protective mechanism for adaptive responses to hypoxia. Stimulation of peripheral chemoreceptors initiates a reflex response that generates compensatory physiological responses, ...
Locoregional techniques for dogs undergoing tibial plateau leveling osteotomy : a literature review, anesthesiologist survey, and future directions
(University of Missouri--Columbia, 2023)
Over the past several decades there have been significant advancements in our understanding and ability to provide effective analgesia to animals undergoing elective orthopedic surgery through methods that can help us ...
Bacterial culture and susceptibility of samples taken from septic foot lesions of adult beef cattle
(University of Missouri--Columbia, 2021)
Lameness is an economically important and common disease of cattle. Foot disease is the most common cause of cattle lameness; however, there are few publications regarding lameness in cow-calf operations. The objectives ...