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    • University of Missouri-Columbia
    • Graduate School - MU Theses and Dissertations (MU)
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    • 2007 Dissertations (MU)
    • 2007 MU dissertations - Access restricted to UM
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    Caveolin-1 A scaffold for microcompartmental organization of membrane-associated glycolysis

    Hernandez, Mark J. (Mark Jerry), 1979-
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    Date
    2007
    Format
    Thesis
    Metadata
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    Abstract
    [ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] The role of membrane caveolae in the compartmentation of membrane glycolytic metabolism indicates a pivotal role of caveolin in the localization of glycolytic enzymes to this membrane domain. This dissertation demonstrates the following about the role of protein scaffold caveolin-1 (CAV-1) in the compartmentation of membrane glycolytic metabolism. 1) CAV-1 a scaffold of phosphofructokinase (PFK) can also target other glycolytic enzymes such as aldolase, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and pyruvate kinase (PK) to the membrane of lymphocytes transfected with caveolin-1 (CAV-1). 2) CAV-1 is subject to regulation during enhanced glycolytic metabolism in astrocytes after 24 hour exposure to high NH4Cl. 3) The caveolin-1 scaffolding domain (CSD) is essential for the targeting of glycolytic enzyme PFK to the cell membrane in the vascular smooth muscle cell line A7r5. This dissertation addressed these three fundamental roles of caveolin-1 that support the essential role of caveolins in the organization of membrane associated glycolytic metabolism.
    URI
    https://doi.org/10.32469/10355/6007
    https://hdl.handle.net/10355/6007
    Degree
    Ph. D.
    Thesis Department
    Physiology (Medicine) (MU)
    Rights
    Access is limited to the campuses of the University of Missouri.
    Collections
    • 2007 MU dissertations - Access restricted to UM
    • Medical Pharmacology and Physiology electronic theses and dissertations (MU)

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